Latest content added for UNT Digital Library Searchhttps://digital2.library.unt.edu/search/?t=fulltext&fq=str_degree_department%3ABiomedical+Engineering&sort=creator2024-03-05T14:34:29-06:00UNT LibrariesThis is a custom feed for searching UNT Digital Library SearchHidden Markov model-based activity recognition for toddlers2020-06-05T16:16:36-05:00https://digital.library.unt.edu/ark:/67531/metadc1639372/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1639372/"><img alt="Hidden Markov model-based activity recognition for toddlers" title="Hidden Markov model-based activity recognition for toddlers" src="https://digital.library.unt.edu/ark:/67531/metadc1639372/thumbnail/"/></a></p><p>Article describes study which sought to evaluate methods for activity recognition for toddlers.</p>UNT Texas Fashion Collection: Assessment and Preservation Training2023-08-24T10:57:21-05:00https://digital.library.unt.edu/ark:/67531/metadc2155276/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2155276/"><img alt="UNT Texas Fashion Collection: Assessment and Preservation Training" title="UNT Texas Fashion Collection: Assessment and Preservation Training" src="https://digital.library.unt.edu/ark:/67531/metadc2155276/thumbnail/"/></a></p><p>Data management plan for the grant, "UNT Texas Fashion Collection: Assessment and Preservation Training."</p>Wearable airbag technology and machine learned models to mitigate falls after stroke2023-10-12T14:18:07-05:00https://digital.library.unt.edu/ark:/67531/metadc2179452/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2179452/"><img alt="Wearable airbag technology and machine learned models to mitigate falls after stroke" title="Wearable airbag technology and machine learned models to mitigate falls after stroke" src="https://digital.library.unt.edu/ark:/67531/metadc2179452/thumbnail/"/></a></p><p>Article discusses wearable airbag technology that has been designed to detect and mitigate fall impact. However, this technology has not been validated for the stroke population, so authors investigated whether population-specific training data and modeling parameters are required to pre-detect falls in a chronic stroke population.</p>Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors2021-09-16T13:07:46-05:00https://digital.library.unt.edu/ark:/67531/metadc1837121/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1837121/"><img alt="Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors" title="Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors" src="https://digital.library.unt.edu/ark:/67531/metadc1837121/thumbnail/"/></a></p><p>Data management plan for the grant "Development of Genetic Sensors and Circuits for Creating Novel Cellular Behaviors." This research is expected to advance the capability to engineer organisms for biomedical uses. Specifically, the outcomes of this project include design principles for engineering regulators from different protein families, an extensive set of genetic sensors for detecting a broad range of signals, and novel genetic circuits that address uprising problems in biomedical fields. It uses a novel multidisciplinary approach to enhance the health of the nation by creating tools that facilitate both medical-related discoveries and the implementation of new strategies for biomedical applications.</p>Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker2021-10-21T11:25:25-05:00https://digital.library.unt.edu/ark:/67531/metadc1852206/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1852206/"><img alt="Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker" title="Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker" src="https://digital.library.unt.edu/ark:/67531/metadc1852206/thumbnail/"/></a></p><p>This article develops a molecular cell tracker with a strong fluorescence signal in the second near-infrared (NIR-II) window (1,000-1,700 nm) for real-time monitoring of in vivo cell behaviors in both healthy and diseased animal models to address the issue of precisely and quantitatively evaluating the in vivo cell distribution, migration, and engraftment in stem cell therapy.</p>Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation2024-03-05T14:34:29-06:00https://digital.library.unt.edu/ark:/67531/metadc2289474/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2289474/"><img alt="Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation" title="Detergent-Based Decellularization for Anisotropic Cardiac-Specific Extracellular Matrix Scaffold Generation" src="https://digital.library.unt.edu/ark:/67531/metadc2289474/thumbnail/"/></a></p><p>Article describes how cell-derived extracellular matrix has become increasingly popular in tissue engineering applications due to its ability to provide tailored signals for desirable cellular responses. The objective of this study was to assess the efficacy of two detergent-based decellularization methods: a combination of ethylenediaminetetraacetic acid and sodium dodecyl sulfate and a combination of sodium deoxycholate and deoxyribonuclease.</p>Flexible and Stretchable Bioelectronics2022-06-29T19:31:08-05:00https://digital.library.unt.edu/ark:/67531/metadc1954000/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1954000/"><img alt="Flexible and Stretchable Bioelectronics" title="Flexible and Stretchable Bioelectronics" src="https://digital.library.unt.edu/ark:/67531/metadc1954000/thumbnail/"/></a></p><p>Article reviewing several several flexible and stretchable materials used as substrate, stretchable electrical conduits and encapsulation, design modifications for stretchability, fabrication techniques, methods of signal transmission and monitoring, and the power sources for these stretchable bioelectronics. Ultimately, these bioelectronic devices can be used for wide range of applications from skin bioelectronics and biosensing devices, to neural implants for diagnostic or therapeutic purposes.</p>Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties2024-03-05T14:22:34-06:00https://digital.library.unt.edu/ark:/67531/metadc2288915/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288915/"><img alt="Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties" title="Multifaceted Shape Memory Polymer Technology for Biomedical Application: Combining Self-Softening and Stretchability Properties" src="https://digital.library.unt.edu/ark:/67531/metadc2288915/thumbnail/"/></a></p><p>Article describes how thiol-ene polymers are a promising class of biomaterials with a wide range of potential applications, including organs-on-a-chip, microfluidics, drug delivery, and wound healing. This study investigated the incorporation of di-acrylate chain extenders to improve the stretchability and conformability of those flexible thiol-ene polymers.</p>On-chip multiplexed single-cell patterning and controllable intracellular delivery2020-06-05T16:16:36-05:00https://digital.library.unt.edu/ark:/67531/metadc1639380/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1639380/"><img alt="On-chip multiplexed single-cell patterning and controllable intracellular delivery" title="On-chip multiplexed single-cell patterning and controllable intracellular delivery" src="https://digital.library.unt.edu/ark:/67531/metadc1639380/thumbnail/"/></a></p><p>Article presents a simple 3D electroporation platform that enables massively parallel single-cell manipulation and the intracellular delivery of macromolecules and small molecules.</p>CAREER: Shape Memory Polymers as Biomaterial2023-01-09T16:32:44-06:00https://digital.library.unt.edu/ark:/67531/metadc2032126/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2032126/"><img alt="CAREER: Shape Memory Polymers as Biomaterial" title="CAREER: Shape Memory Polymers as Biomaterial" src="https://digital.library.unt.edu/ark:/67531/metadc2032126/thumbnail/"/></a></p><p>Data management plan for the grant, "CAREER: Shape Memory Polymers as Biomaterial." This CAREER projectaimsto elucidate the underlying mechanism of the plasticization-induced shape memory effect of thiol-enebased polymers. The model application for this material will be a heat shrink tubing that can shrink at bodily conditions (37° C and simulated body fluids) and can be used to seal colonic anastomosis. The specific three aims are to (1) Systematically investigate the effect of crosslink-density and chain extender length on theplasticization-induced shape memory effect of thiol-enebased polymers. Mechanical and thermomechanical measurements inside simulated body fluids will be used to assess shape memory properties and structure-property relationships. (2) Understand the relationship between material thickness, degree of shape-programming, and radial recovery forces of tube-shaped SMPs to determine optimal design parameters for sufficient shape recovery using the heat shrink tube model. (3) Demonstrate the functionality of a biomedical heat shrink tube that utilizes the plasticization-induced shape recovery through an ex vivo colon anastomosis model and quantify mechanical and sealing properties.</p>Review of Colonic Anastomotic Leakage and Prevention Methods2022-05-27T05:56:10-05:00https://digital.library.unt.edu/ark:/67531/metadc1934149/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1934149/"><img alt="Review of Colonic Anastomotic Leakage and Prevention Methods" title="Review of Colonic Anastomotic Leakage and Prevention Methods" src="https://digital.library.unt.edu/ark:/67531/metadc1934149/thumbnail/"/></a></p><p>This article presents a composite review involving some of the current and best treatments for colonic anastomotic leakage that are available in order to better understand the steps taken to treat this complication.</p>Deep learning for peptide identification from metaproteomics datasets2021-09-22T14:32:09-05:00https://digital.library.unt.edu/ark:/67531/metadc1838847/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1838847/"><img alt="Deep learning for peptide identification from metaproteomics datasets" title="Deep learning for peptide identification from metaproteomics datasets" src="https://digital.library.unt.edu/ark:/67531/metadc1838847/thumbnail/"/></a></p><p>This article explores a proposed deep-learning-based algorithm called DeepFilter for improving peptide identifications from a collection of tandem mass spectra. The authors find that DeepFilter is believed to generalize properly to new, previously unseen peptide-spectrum-matches and can be readily applied in peptide identification from metaproteomics data.</p>Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels2024-03-05T14:18:00-06:00https://digital.library.unt.edu/ark:/67531/metadc2288869/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288869/"><img alt="Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels" title="Mesenchymal stem cells aligned and stretched in self-assembling peptide hydrogels" src="https://digital.library.unt.edu/ark:/67531/metadc2288869/thumbnail/"/></a></p><p>Article describes how the presented research highlights a novel approach using fmoc-protected peptide hydrogels for the encapsulation and stretching of mesenchymal stem cells. This study utilized a custom mechanical stretching device with a PDMS chamber to stretch human mesenchymal stem cells encapsulated in Fmoc hydrogels.</p>Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications2019-03-15T11:51:16-05:00https://digital.library.unt.edu/ark:/67531/metadc1459148/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1459148/"><img alt="Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications" title="Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications" src="https://digital.library.unt.edu/ark:/67531/metadc1459148/thumbnail/"/></a></p><p>This review compares the advantages and disadvantages of decellularization methods in terms of their ability to retain desired extracellular matrix characteristics for particular tissues and organs.</p>New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers2023-08-24T10:57:21-05:00https://digital.library.unt.edu/ark:/67531/metadc2155275/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2155275/"><img alt="New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers" title="New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers" src="https://digital.library.unt.edu/ark:/67531/metadc2155275/thumbnail/"/></a></p><p>Data management plan for the grant, "New approach based on enzyme stimulating of peptides for targeting drug resistance breast cancers." In this project, we propose the development of selective self-assembling peptides that form nanofibers via a self-assembling process upon the action of Eyes absent (EYA) enzyme, specific to drug resistance Triple Negative Breast cancer cells (TNBC). The objectives are: Aim 1: Design and synthesize self-assembling peptide substrates for EYA enzymes; Aim 2:Determining the efficacy of peptide substrates for inhibiting TNBC in spheroid 3D cell cultures. The correlation between the enzyme kinetic and the activity of nanostructures for targeting EYA will be evaluated. Aim 3: The apoptosis response of the TNBC cells will be determined. This study will lead to finding the potent peptide substrate and the effective dose for inhibiting TNBC cells with apoptosis cell death.</p>A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices2023-12-14T05:16:53-06:00https://digital.library.unt.edu/ark:/67531/metadc2201647/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2201647/"><img alt="A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices" title="A Review of Rehabilitative and Assistive Technologies for Upper-Body Exoskeletal Devices" src="https://digital.library.unt.edu/ark:/67531/metadc2201647/thumbnail/"/></a></p><p>Authors state that this journal review article focuses on the use of assistive and rehabilitative exoskeletons as a new opportunity for individuals with diminished mobility. Overall, this article serves as a valuable resource for individuals working in the field of assistive and rehabilitative exoskeletons, providing insight into the state of the art and potential areas for improvement.</p>In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites2022-05-27T05:46:47-05:00https://digital.library.unt.edu/ark:/67531/metadc1934011/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1934011/"><img alt="In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites" title="In-vitro biomineralization and biocompatibility of friction stir additively manufactured AZ31B magnesium alloy-hydroxyapatite composites" src="https://digital.library.unt.edu/ark:/67531/metadc1934011/thumbnail/"/></a></p><p>Article presents research where friction stir additive manufacturing technique was employed to fabricate AZ31B magnesium-hydroxyapatite composite. The study aims to evaluate effect of hydroxyapatite (HA, Ca₁₀(PO₄)₆OH₂), a ceramic similar to natural bone, into AZ31B Mg alloy matrix on biomineralization and biocompatibility.</p>Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis2021-10-21T11:29:43-05:00https://digital.library.unt.edu/ark:/67531/metadc1852258/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1852258/"><img alt="Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis" title="Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis" src="https://digital.library.unt.edu/ark:/67531/metadc1852258/thumbnail/"/></a></p><p>This article is a review that illustrates the involvement of MMP-13 in the initiation and progression of Osteoarthritis (OA) through the regulation of MMP-13 activity at the molecular and epigenetic levels, as well as the strategies that have been employed against MMP-13. The aim of this review is to identify MMP-13 as an attractive target for inhibitor development in the treatment of OA.</p>Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration2021-12-06T08:09:58-06:00https://digital.library.unt.edu/ark:/67531/metadc1863644/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1863644/"><img alt="Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration" title="Bioengineering Systems for Modulating Notch Signaling in Cardiovascular Development, Disease, and Regeneration" src="https://digital.library.unt.edu/ark:/67531/metadc1863644/thumbnail/"/></a></p><p>This article is a review summarizing the significant roles of Notch signaling in individual cardiac cell types. It covers the bioengineering systems of microfluidics, hydrogel, spheroid, and 3D bioprinting and provides insights into ancillary supports of bioengineering systems, varied types of cardiovascular cells, and advanced characterization approaches in further refining Notch signaling in cardiovascular development, disease, and regeneration.</p>Preface: International Conference on Recent Advancements in Biomedical Engineering - 20212022-01-14T16:32:08-06:00https://digital.library.unt.edu/ark:/67531/metadc1877574/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1877574/"><img alt="Preface: International Conference on Recent Advancements in Biomedical Engineering - 2021" title="Preface: International Conference on Recent Advancements in Biomedical Engineering - 2021" src="https://digital.library.unt.edu/ark:/67531/metadc1877574/thumbnail/"/></a></p><p>This article showcasing the editorial team welcomes all readers to the proceedings of International Conference on Recent Advancements in Biomedical Engineering (ICRABE-2021). The conference was inspired by the fusion of science and engineering principles in healthcare services and products. The conference aims to initiate exchange of innovative ideas between students, research scholar and faculties. Specifically, mechanical principles, power control for medical devices, nanomaterials and associated technologies were focused. This proceeding comprises of a broad spectrum of techniques to expose the recent advancements in the field of physics for healthcare application. A List of the Organizing Committee, Advisory Committee, Technical Committee are available in the pdf.</p>CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients2022-01-24T14:30:55-06:00https://digital.library.unt.edu/ark:/67531/metadc1885074/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1885074/"><img alt="CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients" title="CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients" src="https://digital.library.unt.edu/ark:/67531/metadc1885074/thumbnail/"/></a></p><p>Data management plan for the grant "CAREER: A Prosthetic Elbow with Network of Soft and Modular Thermo-Active Actuators for Mobility Impaired Patients." This NSF Faculty Early Career Development (CAREER) project will develop novel networks of flexible Peltier-based soft actuators designed for rehabilitation.</p>Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes2022-06-29T19:32:04-05:00https://digital.library.unt.edu/ark:/67531/metadc1954010/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1954010/"><img alt="Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes" title="Nanocrown electrodes for parallel and robust intracellular recording of cardiomyocytes" src="https://digital.library.unt.edu/ark:/67531/metadc1954010/thumbnail/"/></a></p><p>Article develops vertically-aligned nanocrown electrodes that are mechanically robust and achieve > 99% success rates in obtaining intracellular access through electroporation. This technology development provides an advancement towards establishing an iAP screening assay for preclinical evaluation of drug-induced arrhythmogenicity.</p>Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial2021-09-22T14:36:18-05:00https://digital.library.unt.edu/ark:/67531/metadc1839057/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1839057/"><img alt="Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial" title="Using a microprocessor knee (C-Leg) with appropriate foot transitioned individuals with dysvascular transfemoral amputations to higher performance levels: a longitudinal randomized clinical trial" src="https://digital.library.unt.edu/ark:/67531/metadc1839057/thumbnail/"/></a></p><p>Article evaluating whether advanced prostheses can provide better safety and performance capabilities to maintain and improve quality of life in individuals who are predominantly designated MFCL level K2. This study used a 13 month longitudinal clinical trial to determine the benefits of using a C-Leg and 1M10 foot in individuals at K2 level with transfemoral amputation due to vascular disease.</p>Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model2024-03-05T14:24:15-06:00https://digital.library.unt.edu/ark:/67531/metadc2288926/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288926/"><img alt="Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model" title="Suppression of the antitumoral activity of natural killer cells under indirect coculture with cancer-associated fibroblasts in a pancreatic TIME-on-chip model" src="https://digital.library.unt.edu/ark:/67531/metadc2288926/thumbnail/"/></a></p><p>Article describes how recently, natural killer cells emerged as a treatment option for various solid tumors. The effect of activated pancreatic stellate cells on natural killer cell-mediated anticancer efficacy under three-dimensional coculture conditions was investigated.</p>Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk2017-10-14T21:21:42-05:00https://digital.library.unt.edu/ark:/67531/metadc1020990/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1020990/"><img alt="Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk" title="Potential Toxicity and Underlying Mechanisms Associated with Pulmonary Exposure to Iron Oxide Nanoparticles: Conflicting Literature and Unclear Risk" src="https://digital.library.unt.edu/ark:/67531/metadc1020990/thumbnail/"/></a></p><p>This review article will focus on known risks following iron oxide nanoparticles (IONPs) exposure supported by human, animal, and cell culture-based studies, the potential challenges intrinsic to IONPs toxicity assessment, and how these may contribute to the poorly characterized IONPs toxicity profile.</p>Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells2024-03-05T14:25:00-06:00https://digital.library.unt.edu/ark:/67531/metadc2288933/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288933/"><img alt="Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells" title="Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells" src="https://digital.library.unt.edu/ark:/67531/metadc2288933/thumbnail/"/></a></p><p>Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.</p>New approach for identification pHFO networks to predict epilleptogenesis2022-07-19T07:53:47-05:00https://digital.library.unt.edu/ark:/67531/metadc1961251/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1961251/"><img alt="New approach for identification pHFO networks to predict epilleptogenesis" title="New approach for identification pHFO networks to predict epilleptogenesis" src="https://digital.library.unt.edu/ark:/67531/metadc1961251/thumbnail/"/></a></p><p>Data management plan for the grant, "New approach for identification pHFO networks to predict epilleptogenesis." About 40% of epilepsy patients fail to control seizures after treatment, and currently there is no treatment that can prevent epilepsy. The goal of this study is to perform multi-scale electrophysiological investigations combine with advanced computational algorithm development to understand the characteristics of the pathological brain networks during the latent period of epilepsy. The findings of this project will lead to a better understanding of the network mechanisms of epileptogenesis and suggest novel approaches to prevent the process of epileptogenesis.</p>PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer2020-06-16T10:27:33-05:00https://digital.library.unt.edu/ark:/67531/metadc1703597/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1703597/"><img alt="PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer" title="PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer" src="https://digital.library.unt.edu/ark:/67531/metadc1703597/thumbnail/"/></a></p><p>Article describes study which indicates that nuclear type 2C protein phosphatase (PP2Cδ) impairs p53 acetylation and DNA damage response by compromising BRCA1 function in breast cancer development.</p>A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations2023-09-21T06:34:02-05:00https://digital.library.unt.edu/ark:/67531/metadc2178788/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2178788/"><img alt="A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations" title="A consensus statement on detection of hippocampal sharp wave ripples and differentiation from other fast oscillations" src="https://digital.library.unt.edu/ark:/67531/metadc2178788/thumbnail/"/></a></p><p>Article suggests that common standards for recording, detection, and reporting for intracranial recordings in humans that suggest their role in episodic and semantic memory does not exist. Authors of the article outline the methodological challenges involved in detecting ripple events and offer practical recommendations to improve separation from other high-frequency oscillations, and argue that shared experimental, detection, and reporting standards will provide a solid foundation for future translational discovery.</p>Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells2017-07-11T19:49:35-05:00https://digital.library.unt.edu/ark:/67531/metadc984095/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc984095/"><img alt="Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells" title="Bioabsorbable zinc ion induced biphasic cellular responses in vascular smooth muscle cells" src="https://digital.library.unt.edu/ark:/67531/metadc984095/thumbnail/"/></a></p><p>This article explores the short-term effects of extracellular Zn²⁺ on human smooth muscle cells.</p>Surface Nanostructures Enhanced Biocompatibility and Osteoinductivity of laser-Additively Manufactured CoCrMo Alloys2024-03-05T14:19:46-06:00https://digital.library.unt.edu/ark:/67531/metadc2288887/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288887/"><img alt="Surface Nanostructures Enhanced Biocompatibility and Osteoinductivity of laser-Additively Manufactured CoCrMo Alloys" title="Surface Nanostructures Enhanced Biocompatibility and Osteoinductivity of laser-Additively Manufactured CoCrMo Alloys" src="https://digital.library.unt.edu/ark:/67531/metadc2288887/thumbnail/"/></a></p><p>Article describes how cobalt–chromium–molybdenum (CoCrMo) alloys are widely used in orthopedic implants due to their excellent corrosion and wear resistance and superior mechanical properties. In this study, the authors prepared CoCrMo alloys with surface nanostructures of various aspect ratios (AR) using laser-directed energy deposition (L-DED) and biocorrosion.</p>Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides2023-12-14T05:16:46-06:00https://digital.library.unt.edu/ark:/67531/metadc2201644/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2201644/"><img alt="Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides" title="Light-Controlled Cell–Cell Assembly Using Photocaged Oligonucleotides" src="https://digital.library.unt.edu/ark:/67531/metadc2201644/thumbnail/"/></a></p><p>Article asserts that while techniques that allow one to control the arrangement of cells and direct contact between different cell types have been developed that expand upon simple co-culture methods, specific control over heterojunctions that form between cells is not easily accomplished with current methods, such as 3D cell-printing. In this article, DNA-mediated cell interactions are combined with cell-compatible photolithographic approaches to control cell assembly.</p>Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces2023-08-17T10:59:54-05:00https://digital.library.unt.edu/ark:/67531/metadc2148963/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2148963/"><img alt="Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces" title="Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces" src="https://digital.library.unt.edu/ark:/67531/metadc2148963/thumbnail/"/></a></p><p>Data management plan for the grant, "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces."</p>Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding2021-08-19T10:40:32-05:00https://digital.library.unt.edu/ark:/67531/metadc1833383/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1833383/"><img alt="Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding" title="Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding" src="https://digital.library.unt.edu/ark:/67531/metadc1833383/thumbnail/"/></a></p><p>Data management plan for the grant "Modulating 3D Cellular Connectivity Via Spatially-Controlled Programmable Bonding." This project seeks to demonstrate proof-of-concept for technology that allows one to systematically place cells on substrates to create complex 3D assemblies with precise control over individual cellular interactions. The technology generated within this proposal will open new avenues for studying multicellular communication pathways, stem cell differentiation, and understanding developmental processes. Spatially-defined cell-cell communication plays a critical role in numerous disease and developmental processes that include osteoarthritic degeneration, cancer metastasis, and organ regeneration.</p>Current methods for fabricating 3D cardiac engineered constructs2022-06-29T19:25:38-05:00https://digital.library.unt.edu/ark:/67531/metadc1953923/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1953923/"><img alt="Current methods for fabricating 3D cardiac engineered constructs" title="Current methods for fabricating 3D cardiac engineered constructs" src="https://digital.library.unt.edu/ark:/67531/metadc1953923/thumbnail/"/></a></p><p>Article is a review highlighting the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs.</p>Biofunctionalization of metallic implants by calcium phosphate coatings2020-06-16T10:27:33-05:00https://digital.library.unt.edu/ark:/67531/metadc1703593/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1703593/"><img alt="Biofunctionalization of metallic implants by calcium phosphate coatings" title="Biofunctionalization of metallic implants by calcium phosphate coatings" src="https://digital.library.unt.edu/ark:/67531/metadc1703593/thumbnail/"/></a></p><p>Article provides a brief summary of state-of-art of surface biofunctionalization on implantable metals by CaP coatings.</p>Interfacial Zinc Phosphate is the Key to Controlling Biocompatibility of Metallic Zinc Implants2020-06-16T10:27:33-05:00https://digital.library.unt.edu/ark:/67531/metadc1703650/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1703650/"><img alt="Interfacial Zinc Phosphate is the Key to Controlling Biocompatibility of Metallic Zinc Implants" title="Interfacial Zinc Phosphate is the Key to Controlling Biocompatibility of Metallic Zinc Implants" src="https://digital.library.unt.edu/ark:/67531/metadc1703650/thumbnail/"/></a></p><p>Article examines the roles of all major players in the biocompatibility of zinc, i.e., zinc phosphate (ZnP), zinc oxide (ZnO), zinc hydroxide (Zn(OH)2), pH, and Zn2+.</p>Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response2021-10-21T11:24:57-05:00https://digital.library.unt.edu/ark:/67531/metadc1852201/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1852201/"><img alt="Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response" title="Detection of Parkinson's Disease Through Automated Pupil Tracking of the Post-illumination Pupillary Response" src="https://digital.library.unt.edu/ark:/67531/metadc1852201/thumbnail/"/></a></p><p>This article describes a system for pupil size estimation with a user interface to allow rapid adjustment of parameters and extraction of pupil parameters of interest in order to identify Parkinson's disease (PD) as early as possible.</p>Unsupervised learning in images and audio to produce neural receptive fields: a primer and accessible notebook2022-06-29T19:28:50-05:00https://digital.library.unt.edu/ark:/67531/metadc1953972/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1953972/"><img alt="Unsupervised learning in images and audio to produce neural receptive fields: a primer and accessible notebook" title="Unsupervised learning in images and audio to produce neural receptive fields: a primer and accessible notebook" src="https://digital.library.unt.edu/ark:/67531/metadc1953972/thumbnail/"/></a></p><p>This article presents a consolidated review of Independent Component Analysis (ICA) as an efficient neural coding scheme with the ability to model early visual and auditory neural processing.</p>Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries2024-03-05T14:19:21-06:00https://digital.library.unt.edu/ark:/67531/metadc2288886/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2288886/"><img alt="Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries" title="Nanotopographical Cues Tune the Therapeutic Potential of Extracellular Vesicles for the Treatment of Aged Skeletal Muscle Injuries" src="https://digital.library.unt.edu/ark:/67531/metadc2288886/thumbnail/"/></a></p><p>Article describes how skeletal muscle regeneration relies on the tightly temporally regulated lineage progression of muscle stem/progenitor cells (MPCs) from activation to proliferation and finally, differentiation. The authors developed an engineering strategy to tune the therapeutic potential of EVs using nanotopographical cues.</p>Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation2023-12-14T05:11:19-06:00https://digital.library.unt.edu/ark:/67531/metadc2201573/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2201573/"><img alt="Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation" title="Harnessing nanofiber alignment and pore size to promote stem cell self-renewal and differentiation" src="https://digital.library.unt.edu/ark:/67531/metadc2201573/thumbnail/"/></a></p><p>Article describes how stem cell therapy holds immense potential for regenerative medicine, but its applications are limited due to the loss of pluripotency during in vitro expansion. This study reveals that the arrangement of electrospun fibers aligns with the distribution and strength of the electric field through both experimentation and simulation.</p>Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease2023-06-02T05:42:24-05:00https://digital.library.unt.edu/ark:/67531/metadc2114241/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc2114241/"><img alt="Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease" title="Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease" src="https://digital.library.unt.edu/ark:/67531/metadc2114241/thumbnail/"/></a></p><p>Data management plan for the grant, "Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease."</p>Corrigendum to “Metabolic Syndrome, Inflammation, and Cancer”2020-08-03T15:07:04-05:00https://digital.library.unt.edu/ark:/67531/metadc1705450/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1705450/"><img alt="Corrigendum to “Metabolic Syndrome, Inflammation, and Cancer”" title="Corrigendum to “Metabolic Syndrome, Inflammation, and Cancer”" src="https://digital.library.unt.edu/ark:/67531/metadc1705450/thumbnail/"/></a></p><p>Corrigendum to the article titled “Metabolic Syndrome, Inflammation, and Cancer”.</p>Metabolic Syndrome, Inflammation, and Cancer2020-08-03T15:07:04-05:00https://digital.library.unt.edu/ark:/67531/metadc1705536/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1705536/"><img alt="Metabolic Syndrome, Inflammation, and Cancer" title="Metabolic Syndrome, Inflammation, and Cancer" src="https://digital.library.unt.edu/ark:/67531/metadc1705536/thumbnail/"/></a></p><p>Article introducing a special issue discussing the link between the metabolic syndrome and the development and progression of cancer. The role of inflammation in these diseases and identification of new therapeutic targets are of great significance. This special issue contributes original research papers and review articles that motivate the continuous efforts to comprehend the mechanisms, production, and management related to cancers associated with the metabolic syndrome.</p>The Effect of Magnesium Deficiency on Neurological Disorders: A Narrative Review Article2022-06-15T15:16:35-05:00https://digital.library.unt.edu/ark:/67531/metadc1944129/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1944129/"><img alt="The Effect of Magnesium Deficiency on Neurological Disorders: A Narrative Review Article" title="The Effect of Magnesium Deficiency on Neurological Disorders: A Narrative Review Article" src="https://digital.library.unt.edu/ark:/67531/metadc1944129/thumbnail/"/></a></p><p>This article critically discusses the role of Magnesium by reviewing recent literature and available data concerning the role of magnesium in neurological disorders. The authors summarize the role of Mg in neurological disorders to illustrate the symptoms caused by Mg-deficiency and the possible underlying mechanisms.</p>Child Health and Human Development Extramural Research2022-10-12T20:03:40-05:00https://digital.library.unt.edu/ark:/67531/metadc1996918/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1996918/"><img alt="Child Health and Human Development Extramural Research" title="Child Health and Human Development Extramural Research" src="https://digital.library.unt.edu/ark:/67531/metadc1996918/thumbnail/"/></a></p><p>Data management plan for the grant, "Child Health and Human Development Extramural Research." This study will use the genome-edited human induced pluripotent stem cell (hiPSC) with NOTCH1 knockout to recapitulate the genetic variants of NOTCH1 mutation in the Hypoplastic left heart syndrome (HLHS). It will use advances in the vascularized cardiac organoid directly differentiated from hiPSCs to replay the development and function of cardiomyocytes, endothelial cells, smooth muscle cells, and other cardiac cells in a defined 3D cell culture model by stencil-based micropatterning. It will elucidate the pathogenesis of cardiovascular underdevelopment and dysfunction found in HLHS with NOTCH1 mutation via the NOTCHDELTA/JAG ligand-receptor binding and multicellular crosstalk by single-cell RNA-seq and proteomics analysis.</p>Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration2022-10-12T20:03:40-05:00https://digital.library.unt.edu/ark:/67531/metadc1997567/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1997567/"><img alt="Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration" title="Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration" src="https://digital.library.unt.edu/ark:/67531/metadc1997567/thumbnail/"/></a></p><p>Data management plan for the grant, "Optic-nerve-head (ONH) Chips for Glaucomatous Neurodegeneration." The most prominent causative risk factor of glaucoma, the leading cause of irreversible blindness worldwide, is elevated intraocular pressure (IOP), which could deform the optic nerve head (ONH) and cause glaucomatous neurodegeneration. However, current glaucoma therapies that focus on lowering IOP do not stop vision loss effectively, and thus there is a pressing need to understand the mechanisms underlying glaucoma pathogenesis. In this project, we will develop a biomimetic 3-D ONH-on-a-chip system that closely mimics the key anatomical and pathophysiological characteristics of the native ONH to study astrocytic mechanisms of glaucoma pathogenesis, a missing link to develop efficacious therapies.</p>A Dense Stereovision System for 3D Body Imaging2020-06-16T10:27:33-05:00https://digital.library.unt.edu/ark:/67531/metadc1703639/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1703639/"><img alt="A Dense Stereovision System for 3D Body Imaging" title="A Dense Stereovision System for 3D Body Imaging" src="https://digital.library.unt.edu/ark:/67531/metadc1703639/thumbnail/"/></a></p><p>Article presents a 3D body imaging system built upon stereovision technology which utilizes paired, high-resolution single-lens reflex (SLR) cameras to image the front and back body surfaces of a person, and robust and efficient stereo matching algorithms to reconstruct the 3D surface of the body with high-density data clouds.</p>Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale2022-06-29T19:29:44-05:00https://digital.library.unt.edu/ark:/67531/metadc1953984/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1953984/"><img alt="Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale" title="Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale" src="https://digital.library.unt.edu/ark:/67531/metadc1953984/thumbnail/"/></a></p><p>This review article summarizes the latest neuropathological discoveries at the molecular, cellular, and tissue levels involving both animal and patient studies, aiming to explore epileptogenesis and highlight new potential targets in the diagnosis and treatment of temporal lobe epilepsy (TLE).</p>Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning2022-05-27T05:49:06-05:00https://digital.library.unt.edu/ark:/67531/metadc1934050/<p><a href="https://digital.library.unt.edu/ark:/67531/metadc1934050/"><img alt="Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning" title="Accelerometer-Based Automated Counting of Ten Exercises without Exercise-Specific Training or Tuning" src="https://digital.library.unt.edu/ark:/67531/metadc1934050/thumbnail/"/></a></p><p>Article presents research that creates an automatic repetition counting system that is flexible enough to measure multiple distinct and repeating movements during physical therapy without being trained on the specific motion.</p>