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Adherence to Exercise Programs in Older Adults: Informative Report
This article focuses on filling information gaps regarding adherence to physical activity and exercise in the health care spectrum of older adults (OA) and an overview of the benefits of physical activity for OA. Exercise adherence in OA is a multifactorial problem encompassing many biopsychosocial factors. Factors affecting adherence in the OA include socioeconomic status, education level, living arrangements, health status, pacemakers, physical fitness, and depression. Improving adherence could have a significant impact on longevity, quality of life, and health care costs.
Date:
January 22, 2019
Creator:
Rivera-Torres, Solymar; Fahey, Thomas D. & Rivera, Miguel A.
Object Type:
Article
System:
The UNT Digital Library
Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms
This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date:
July 20, 2010
Creator:
Jung, Marianna E. & Metzger, Daniel B.
Object Type:
Article
System:
The UNT Digital Library
Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents
This article is a review of prodrug design for brain delivery of small- and medium-sized neuropeptides, focusing on thyrotropin-releasing hormone and structurally related peptides as examples.
Date:
February 6, 2009
Creator:
Prokai-Tatrai, Katalin & Prókai, László, 1958-
Object Type:
Article
System:
The UNT Digital Library
Tetracycline-Containing MCM-41 Mesoporous Silica Nanoparticles for the Treatment of Escherichia coli
Paper describes study testing the effectiveness of tetracycline (TC) in mobile crystalline material 41 (MCM-41) for controlled drug release.
Date:
October 30, 2019
Creator:
Koneru, Bhuvaneswari; Shi, Yi; Wang, Yu-Chieh; Chavala, Sai H.; Miller, Michael L.; Holbert, Brittany et al.
Object Type:
Article
System:
The UNT Digital Library
NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner
This article's study endeavors to determine if p53 is responsible for cisplatin sensitization by NSC109268. Results have implications for sensitivity of ovarian cancer cells to cisplatin independent of p53.
Date:
October 5, 2010
Creator:
Shankar, Eswar; Basu, Chandreyi; Adkins, Brett; Siede, Wolfram & Basu, Alakananda
Object Type:
Article
System:
The UNT Digital Library
Transitioning from Acute to Chronic Pain: An Examination of Different Trajectories of Low-Back Pain
The article examines the most recent trajectory research, and highlights the importance of developing a broader model for patient evaluation. Traditionally, there has been a widely accepted notion that the transition from acute to chronic pain follows a linear trajectory, where an injury leads to acute episodes, subacute stages, and progresses to a chronic pain condition. However, it appears that pain progression is much more complicated and individualized than this original unsupported assumption.
Date:
May 17, 2018
Creator:
Gatchel, Robert J.; Bevers, Kelley; Licciardone, John C.; Su, Jianzhong; Du, Ying & Brotto, Marco
Object Type:
Article
System:
The UNT Digital Library
Harnessing Data to Assess Equity of Care by Race, Ethnicity and Language
Study examines disparities in healthcare based on race, ethnicity and language (REaL) by utilizing inpatient (IP) core measures at Texas Health Resources, a large, faith-based, non-profit healthcare system located in Texas.
Date:
December 22, 2015
Creator:
Gracia, Amber; Cheirif, Jorge; Veliz, Juana; Reyna, Melissa; Vecchio, Mara & Aryal, Subhash
Object Type:
Article
System:
The UNT Digital Library
Aircraft-Assisted Pilot Suicides in the General Aviation Increased for One-Year Period after 11 September 2001 Attack in the United States
The article describes a study that evaluated the possible effect the 11 September 2001, terrorist attacks had on pilot AASs in the U.S. Fatal aviation accidents in the National Transportation Safety Board (NTSB) database were searched using the following search words: “suicide”, “murder-suicide” and “homicide-suicide”. The timeline between 11 September 1996, and 11 September 2004, was analyzed. This study showed an association, albeit not determinate causal effect, of a very specific series of simultaneous terrorist murder-suicides with subsequent pilot AASs.
Date:
November 12, 2018
Creator:
Vuorio, Alpo; Laukkala, Tanja; Junttila, Ilkka; Bor, Robert; Budowle, Bruce; Pukkala, Eero et al.
Object Type:
Article
System:
The UNT Digital Library
“Youth Are More Aware and Intelligent than Imagined”: The Mountain Air Youth Photovoice Project
This article looks at respiratory illness in Appalachian Kentucky because it reports some of the highest rates of respiratory illness in the United States. As part of the Mountain Air Project, local youth were invited to share their perspectives on possible contributing factors to respiratory illness, and the authors undertook an exploratory study to determine the utility of photovoice to elicit such perspectives with this population. This study demonstrates the value of incorporating youth perspectives in environmental health research, and that photovoice was a valuable approach to elicit such perspectives.
Date:
October 11, 2019
Creator:
Cardarelli, Katheryn M.; Paul, Marcy; May, Beverly; Dunfee, Madeline; Browning, Steven & Schoenberg, Nancy
Object Type:
Article
System:
The UNT Digital Library
Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident
Paper describes studying aiming to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps.
Date:
March 11, 2018
Creator:
Laukkala, Tanja; Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero et al.
Object Type:
Article
System:
The UNT Digital Library
The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma
This article analyzes the Delaware Hospital Discharge Database, and identified state and non-state residents discharged with AMI or asthma for the years 1999 to 2004. Statistical data analysis compared the incidence of AMI or asthma for each group before (1999–2002) and after (2003–2004) the amendment. As a result, the authors found that pre-ordinance and post-ordinance quarterly rates of AMI for Delaware residents were 451 (se = 21) and 430 (se = 21) respectively, representing a 4.7% reduction.
Date:
December 2, 2010
Creator:
Moraros, John; Bird, Yelena; Chen, Shande; Buckingham, Robert; Meltzer, Richard S.; Prapasiri, Surasri et al.
Object Type:
Article
System:
The UNT Digital Library
The Implications of Cancer Stem Cells for Cancer Therapy
This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date:
December 5, 2012
Creator:
Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
Object Type:
Article
System:
The UNT Digital Library
Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target
This article focuses on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury.
Date:
March 8, 2016
Creator:
Jin, Zhen; Wu, Jinzi & Yan, Liang-Jun
Object Type:
Article
System:
The UNT Digital Library
Humanin Attenuates NMDA-Induced Excitotoxicity by Inhibiting ROS-dependent JNK/p38 MAPK Pathway
This article highlights a study aimed to investigate neuroprotective mechanisms of HN. We analyzed intracellular Ca²+ levels, reactive oxygen species (ROS) production, and the MAPKs signal transduction cascade using an in vitro NMDA-mediated excitotoxicity of cortical neurons model.
Date:
September 29, 2018
Creator:
Yang, Xiaorong; Zhang, Hongmei; Wu, Jinzi; Yin, Litian; Yan, Liang-Jun & Zhang, Ce
Object Type:
Article
System:
The UNT Digital Library
Role of the Ubiquitin Proteasome System (UPS) in the HIV-1 Life Cycle
This article is an overview the interplay between HIV-1 viral and cellular proteins for restrictions/competitions for proliferation of the virus in the infected cell, which could open a new avenue for the development of therapeutics against HIV-1 via targeting a specific step of the proteasome degradation pathway during the HIV-1 life cycle.
Date:
June 19, 2019
Creator:
Rojas, Vivian K. & Park, In-Woo
Object Type:
Article
System:
The UNT Digital Library
Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications
This review highlights recent studies and progress involved in understanding the development of cutaneous melanocytes and the regulation of McSCs. Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the epidermis of the skin.
Date:
December 21, 2015
Creator:
Mull, Amber N.; Zolekar, Ashwini & Wang, Yu-Chieh
Object Type:
Article
System:
The UNT Digital Library
Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody
This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.
Date:
February 12, 2015
Creator:
Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
Object Type:
Article
System:
The UNT Digital Library
Expression and Function of Transient Receptor Potential Ankyrin 1 Ion Channels in the Caudal Nucleus of the Solitary Tract
The article describes a study that tested and confirmed the hypothesis that TRPA1 expressed in the primary sensory afferents may modulate the function of second order NTS neurons. The expression of TRPA1 was detected in presynaptic locations, but not the somata of caudal NTS neurons that did not express TRPA1 mRNA or proteins. Moreover, caudal NTS neurons did not show somatodendritic responsiveness to TRPA1 agonists, while TRPA1 immunostaining was detected only in the afferent fibers.
Date:
April 26, 2019
Creator:
Feng, Lin; Uteshev, Victor V. & Premkumar, Louis S.
Object Type:
Article
System:
The UNT Digital Library
Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1)
The article explores Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. Their results showed that treatment with Sal B protected primary human RPE cells from H₂O₂-induced cell damage. They found Sal B pretreatment upregulated Grx1 expression in RPE cells in a time- and dose-dependent manner.
Date:
November 3, 2016
Creator:
Liu, Xiaobin; Xavier, Christy; Jann, Jamieson & Wu, Hongli
Object Type:
Article
System:
The UNT Digital Library
Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats
Paper examines the effects of transplanted neural stem cells (NSCs) on subpopulations of T lymphocytes and their corresponding cytokines when used to treat brain injury, using rats as a case study.
Date:
March 13, 2014
Creator:
Gao, Lu; Lu, Qin; Huang, Li-Jie; Ruan, Lin-Hui; Yang, Jian-Jing; Huang, Wei-Long et al.
Object Type:
Article
System:
The UNT Digital Library
Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry
Paper describes results of an analysis of the organothiophosphate malathion using DART-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) and tandem mass spectrometry (MS/MS).
Date:
January 16, 2016
Creator:
Prókai, László, 1958- & Stevens, Stanley M.
Object Type:
Article
System:
The UNT Digital Library
Protein Modification by ADP-ribose via Acid-labile Linkages
Article describing the preparation and chemical characterization of low molecular weight conjugates that were used as models for an acetal linkage between ADP-ribose and the hydroxyl group of a protein acceptor such as serine, threonine, tyrosine, hydroxyproline, or hydroxylysine residues. The amount of modification was approximately 16 pmol of ADP-ribose per mg of total protein, and proteins modified by acid-labile linkages were detected in all subcellular fractions examined, suggesting that the scope of this modification in vivo is broad.
Date:
April 7, 1995
Creator:
Cervantes-Laurean, Daniel; Loflin, Paul T.; Minter, David E.; Jacobson, Elaine L. & Jacobson, Myron K.
Object Type:
Article
System:
The UNT Digital Library
Peripheral Circulating Exosomal miRNAs Potentially Contribute to the Regulation of Molecular Signaling Networks in Aging
This article aims to understand some of the causes of aging and the underlying mechanisms that may lead to interventions that could reverse certain aging processes and slow development of aging-related diseases. People are living longer than ever. Consequently, they have a greater chance for developing a functional impairment or aging-related disease, such as a neurodegenerative disease, later in life.
Date:
March 11, 2020
Creator:
Zhang, Hongxia & Jin, Kunlin
Object Type:
Article
System:
The UNT Digital Library
Kynurenic Acid Protects Against Ischemia/Reperfusion-Induced Retinal Ganglion Cell Death in Mice
Study investigated the role of the neuroprotective kynurenic acid (KYNA) in RGC death against retinal ischemia/reperfusion (I/R) injury.
Date:
March 5, 2020
Creator:
Nahomi, Rooban B.; Nam, Mi-Hyun; Rankenberg, Johanna; Rakete, Stefan; Houck, Julie A.; Johnson, Ginger C. et al.
Object Type:
Article
System:
The UNT Digital Library