Fabrication of LiAlO{sub 2} target elements for the N-Reactor Coproduct Demonstration Program required development of a suitable fabrication process consistent with installation of a minimum production facility on a limited time schedule. The most advanced manufacturing process developed and used within the facility and schedule constraints is described in detail. Major problems encountered in obtaining required component materials and development of the fabrication process are discussed and analyzed for impact on future programs utilizing LiAlO{sub 2} target elements.

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It was noted previously that 3-(p-dimethylamino)-2-phenyloxaziridine (I) and 3-(p-dimethylamino)-2-(m-nitrophenyl)oxaziridine were photosensitive. Further study on the irradiation (in a variety of solvents under nitrogen) of (I), 2,3-diphenyloxaziridine (II), and 3-(p-nitrophenyl)-2-phenyloxaziridine (III) indicates the major photoreaction to be cleavage to the aldehyde and an intermediate which forms aniline and azobenzene. There is also formed in the photolysis varying amounts of the corresponding anilide. A table provided gives the yields in three different solvents.

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This is number six in a planned series of reports intended to show the status and rates of deterioration of the iron-masonite biological shields of B, Dg DR, F, and H reactors. Since DR, F, and H reactors are in the deactivated state this is the final such report for them. Following the deactivation of D Reactor at the end of June, 1967, B Reactor will be the only one (out of the five with which the shield deterioration study began) to continue operating. Data for this report pertain to the top and left (far) side of the reactors and covers the period from January, 1963, through December, 1966.

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We have attempted to determine the relative biological effectiveness (RBE) of negative pions in the Bragg-peak region as compared to the plateau region and to gamma rays. We irradiated LAF{sub 1} mice, bearing 5-day-old lymphoma ascites tumors, in the peak and plateau regions of a 90-MeV pion beam for 40 hours in temperature-controlled holders. The animals were then sacrificed; lymphoma cells were withdrawn and titrated into adult female LAF{sub 1} mice. The proliferative capacity of the irradiated tumor cells was evaluated after 8 weeks by observing the percentage of animals developing ascites tumors. Surviving fractions were then calculated from LD{sub 50}`s of control and irradiated animals. Radiation doses in the 50 plateau region were measured with LiF dosimeters calibrated against cobalt-60 gamma rays. We calculated peak doses from those at the plateau, using a measured average peak-to-plateau ionization ratio of 1.5. Doses in the plateau region ranged from 145 to 250 rads; doses in the peak region ranged from 220 to 380 rads. The survival curve for cells irradiated in the peak region gave a D{sub 0} of 65 {plus_minus} 15 rads. The plateau points were not reliable. A replicate experiment was performed using Co{sup 60} {gamma}-rays, yielding a survival-curve …

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