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Protein Modification by ADP-ribose via Acid-labile Linkages (open access)

Protein Modification by ADP-ribose via Acid-labile Linkages

Article describing the preparation and chemical characterization of low molecular weight conjugates that were used as models for an acetal linkage between ADP-ribose and the hydroxyl group of a protein acceptor such as serine, threonine, tyrosine, hydroxyproline, or hydroxylysine residues. The amount of modification was approximately 16 pmol of ADP-ribose per mg of total protein, and proteins modified by acid-labile linkages were detected in all subcellular fractions examined, suggesting that the scope of this modification in vivo is broad.
Date: April 7, 1995
Creator: Cervantes-Laurean, Daniel; Loflin, Paul T.; Minter, David E.; Jacobson, Elaine L. & Jacobson, Myron K.
Object Type: Article
System: The UNT Digital Library
Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents (open access)

Prodrugs of Thyrotropin-Releasing Hormone and Related Peptides as Central Nervous System Agents

This article is a review of prodrug design for brain delivery of small- and medium-sized neuropeptides, focusing on thyrotropin-releasing hormone and structurally related peptides as examples.
Date: February 6, 2009
Creator: Prokai-Tatrai, Katalin & Prókai, László, 1958-
Object Type: Article
System: The UNT Digital Library
Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms (open access)

Alcohol Withdrawal and Brain Injuries: Beyond Classical Mechanisms

This review attempts to provide integrated information at the levels of oxidative signaling mechanisms by which ethanol withdrawal (EW) provokes brain injuries and 17β-estradiol (E2) protects against it. Unmanaged sudden withdrawal from the excessive consumption of alcohol (ethanol) adversely alters neuronal integrity in vulnerable brain regions such as the cerebellum, hippocampus, or cortex.
Date: July 20, 2010
Creator: Jung, Marianna E. & Metzger, Daniel B.
Object Type: Article
System: The UNT Digital Library
NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner (open access)

NSC109268 potentiates cisplatin-induced cell death in a p53-independent manner

This article's study endeavors to determine if p53 is responsible for cisplatin sensitization by NSC109268. Results have implications for sensitivity of ovarian cancer cells to cisplatin independent of p53.
Date: October 5, 2010
Creator: Shankar, Eswar; Basu, Chandreyi; Adkins, Brett; Siede, Wolfram & Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma (open access)

The Impact of the 2002 Delaware Smoking Ordinance on Heart Attack and Asthma

This article analyzes the Delaware Hospital Discharge Database, and identified state and non-state residents discharged with AMI or asthma for the years 1999 to 2004. Statistical data analysis compared the incidence of AMI or asthma for each group before (1999–2002) and after (2003–2004) the amendment. As a result, the authors found that pre-ordinance and post-ordinance quarterly rates of AMI for Delaware residents were 451 (se = 21) and 430 (se = 21) respectively, representing a 4.7% reduction.
Date: December 2, 2010
Creator: Moraros, John; Bird, Yelena; Chen, Shande; Buckingham, Robert; Meltzer, Richard S.; Prapasiri, Surasri et al.
Object Type: Article
System: The UNT Digital Library
Single actomyosin motor interactions in skeletal muscle (open access)

Single actomyosin motor interactions in skeletal muscle

This article presents a study of intramuscular motion during contraction of skeletal muscle myofibrils.
Date: February 21, 2011
Creator: Földes-Papp, Zeno; Liao, Jeff Shih-Chu; Barbieri, Ben; Grycznski, Karol G.; Luchowski, Rafal; Gryczynski, Ignacy et al.
Object Type: Article
System: The UNT Digital Library
Regulation of Autophagy by Kinases (open access)

Regulation of Autophagy by Kinases

This review focuses on the regulation of autophagy by several kinases with particular emphasis on serine/threonine protein kinases such as mTOR, AMP-activated kinase, Akt, mitogen-activated protein kinase (ERK, p38 and JNK) and protein kinase C that are often deregulated in cancer and are important therapeutic targets.
Date: June 9, 2011
Creator: Sridharan, Savitha; Jain, Kirti & Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
The Implications of Cancer Stem Cells for Cancer Therapy (open access)

The Implications of Cancer Stem Cells for Cancer Therapy

This review summarizes the characteristics, evidences and development of CSCs, as well as implications and challenges for cancer treatment. Surgery, radiotherapy and chemotherapy are universally recognized as the most effective anti-cancer therapies. Recent studies have showed that cancer stem cells (CSCs), a small subpopulation of tumor cells, can generate bulk populations of nontumorigenic cancer cell progeny through the self-renewal and differentiation processes.
Date: December 5, 2012
Creator: Jiang, Wenjing; Peng, Jianhua; Zhang, Yue; Cho, William C. S. & Jin, Kunlin
Object Type: Article
System: The UNT Digital Library
The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer (open access)

The Potential Role of Nanotechnology in Therapeutic Approaches for Triple Negative Breast Cancer

This review is focused on opportunities for developing new approaches for filling the current void in an effective treatment for Triple Negative Breast Cancer, TNBC, patients. Triple Negative Breast Cancer, TNBC, a highly aggressive and metastatic type of breast cancer, is characterized by loss of expression of the estrogen receptor (ER), progesterone receptor (PR), and a lack of overexpression of the human epidermal growth factor receptor 2 (HER2).
Date: June 18, 2013
Creator: Johnson, Rebecca; Sabnis, Nirupama; McConathy, Walter J. & Lacko, Andras G.
Object Type: Article
System: The UNT Digital Library
Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats (open access)

Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats

Paper examines the effects of transplanted neural stem cells (NSCs) on subpopulations of T lymphocytes and their corresponding cytokines when used to treat brain injury, using rats as a case study.
Date: March 13, 2014
Creator: Gao, Lu; Lu, Qin; Huang, Li-Jie; Ruan, Lin-Hui; Yang, Jian-Jing; Huang, Wei-Long et al.
Object Type: Article
System: The UNT Digital Library
The Multifunctional Protein Kinase C-ε in Cancer Development and Progression (open access)

The Multifunctional Protein Kinase C-ε in Cancer Development and Progression

Paper focuses on the role of protein kinase C in different processes that lead to cancer development and progression.
Date: April 10, 2014
Creator: Jain, Kirti & Basu, Alakananda
Object Type: Article
System: The UNT Digital Library
Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody (open access)

Development of Biodegradable Nanocarriers Loaded with a Monoclonal Antibody

This article examines the feasibility of encapsulating monoclonal antibodies within poly(lactic-co-glycolic acid) (PLGA) nanoparticles using a water/oil/water double emulsion solvent evaporation technique. This method can be used to prepare protective polymeric nanoparticles for transporting functional antibodies to the cytoplasmic compartment of cancer cells. The author's studies achieved successful formulation of antibody loaded polymeric nanoparticles, thus indicating that a PLGA-based antibody nanoformulation is a promising intracellular delivery vehicle for a large number of new intracellular antibody targets in cancer cells.
Date: February 12, 2015
Creator: Gdowski, Andrew; Ranjan, Amalendu; Mukerjee, Anindita & Vishwanatha, Jamboor
Object Type: Article
System: The UNT Digital Library
Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications (open access)

Understanding Melanocyte Stem Cells for Disease Modeling and Regenerative Medicine Applications

This review highlights recent studies and progress involved in understanding the development of cutaneous melanocytes and the regulation of McSCs. Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the epidermis of the skin.
Date: December 21, 2015
Creator: Mull, Amber N.; Zolekar, Ashwini & Wang, Yu-Chieh
Object Type: Article
System: The UNT Digital Library
Harnessing Data to Assess Equity of Care by Race, Ethnicity and Language (open access)

Harnessing Data to Assess Equity of Care by Race, Ethnicity and Language

Study examines disparities in healthcare based on race, ethnicity and language (REaL) by utilizing inpatient (IP) core measures at Texas Health Resources, a large, faith-based, non-profit healthcare system located in Texas.
Date: December 22, 2015
Creator: Gracia, Amber; Cheirif, Jorge; Veliz, Juana; Reyna, Melissa; Vecchio, Mara & Aryal, Subhash
Object Type: Article
System: The UNT Digital Library
Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry (open access)

Direct Analysis in Real Time (DART) of an Organothiophosphate at Ultrahigh Resolution by Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Tandem Mass Spectrometry

Paper describes results of an analysis of the organothiophosphate malathion using DART-Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometry (MS) and tandem mass spectrometry (MS/MS).
Date: January 16, 2016
Creator: Prókai, László, 1958- & Stevens, Stanley M.
Object Type: Article
System: The UNT Digital Library
Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target (open access)

Chemical Conditioning as an Approach to Ischemic Stroke Tolerance: Mitochondria as the Target

This article focuses on chemical conditioning of mitochondrial proteins as targets for neuroprotection against ischemic stroke injury.
Date: March 8, 2016
Creator: Jin, Zhen; Wu, Jinzi & Yan, Liang-Jun
Object Type: Article
System: The UNT Digital Library
Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers (open access)

Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

The article looks at Triazine and PAMAM dendrimers of similar size and number of cationic surface groups and compared them for their ability to promote platelet aggregation.
Date: March 29, 2016
Creator: Enciso, Alan E.; Neun, Barry; Rodriguez, Jamie & Ranjan, Amalendu P.
Object Type: Article
System: The UNT Digital Library
Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients (open access)

Safety of Continuous Infusion Ketorolac in Postoperative Coronary Artery Bypass Graft Surgery Patients

This article evaluates the safety of continuous infusion ketorolac which is sometimes utilized for analgesia in postoperative coronary artery bypass graft (CABG) patients. This retrospective cohort study evaluated the primary outcome of mortality and secondary outcomes of incidence of bleeding and myocardial infarction (MI). No association was found between continuous infusion ketorolac and increased risk of mortality, MI, or bleeding events in postoperative CABG patients.
Date: June 28, 2016
Creator: Howard, Meredith L.; Warhurst, Robert D. & Sheehan, Courtney
Object Type: Article
System: The UNT Digital Library
Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel (open access)

Investigation of the Dermal Absorption and Irritation Potential of Sertaconazole Nitrate Anhydrous Gel

Study used in vitro tape stripping to evaluate efficacy of an anhydrous gel containing sertaconazole nitrate.
Date: July 7, 2016
Creator: Manian, Mahima; Madrasi, Kumpal & Chaturvedula, Ayyappa
Object Type: Article
System: The UNT Digital Library
Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1) (open access)

Salvianolic Acid B (Sal B) Protects Retinal Pigment Epithelial Cells from Oxidative Stress-Induced Cell Death by Activating Glutaredoxin 1 (Grx1)

The article explores Salvianolic acid B (Sal B), a natural compound, as a Grx1 inducer, which potently protected retinal pigment epithelial (RPE) cells from oxidative injury. Their results showed that treatment with Sal B protected primary human RPE cells from H₂O₂-induced cell damage. They found Sal B pretreatment upregulated Grx1 expression in RPE cells in a time- and dose-dependent manner.
Date: November 3, 2016
Creator: Liu, Xiaobin; Xavier, Christy; Jann, Jamieson & Wu, Hongli
Object Type: Article
System: The UNT Digital Library

Data from the National Library of Medicine

Presentation for the 2017 UNT Open Access Symposium. This presentation provides an overview of data types and repositories for accessing data from the National Library of Medicine.
Date: May 19, 2017
Creator: Burgard, Daniel E.
Object Type: Presentation
System: The UNT Digital Library
Flanking Variation Influences Rates of Stutter in Simple Repeats (open access)

Flanking Variation Influences Rates of Stutter in Simple Repeats

This article shows that rates of stutter can vary substantially depending on the flanking haplotype, and while there are cases where the LUS is a better predictor of stutter than the PAL, examples to the contrary are apparent in commonly assayed forensic markers. Further, flanking variation that is 7 bp from the repeat region can impact rates of stutter. These findings suggest that non-proximal effects, such as DNA secondary structure, may be impacting the rates of stutter in common forensic short tandem repeat markers.
Date: November 17, 2017
Creator: Woerner, August E.; King, Jonathan L. & Budowle, Bruce
Object Type: Article
System: The UNT Digital Library
Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2 (open access)

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-2

This article is part of a series of Editorials published biannually that highlights a number of recently published articles that describe crucial findings.
Date: December 28, 2017
Creator: Muñoz-Torrero, Diego; Mangoni, Arduino A; Liu, Hong; Hulme, Christopher; Rautio, Jarkko; Karaman, Rafik et al.
Object Type: Article
System: The UNT Digital Library
Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident (open access)

Copycats in Pilot Aircraft-Assisted Suicides after the Germanwings Incident

Paper describes studying aiming to evaluate changes in pilot aircraft-assisted suicide risks, i.e., a copycat effect, in the U.S. and Germany after the Germanwings 2015 incident in the French Alps.
Date: March 11, 2018
Creator: Laukkala, Tanja; Vuorio, Alpo; Bor, Robert; Budowle, Bruce; Navathe, Pooshan; Pukkala, Eero et al.
Object Type: Article
System: The UNT Digital Library