The underlying hypothesis of this project was that optimal alpha emitter-based radioimmunotherapy (RAIT) could be achieved by pairing the physical half-life of the radioisotope to the biological half-life of the targeting vehicle. The project had two specific aims. The first aim was to create and optimize the therapeutic efficacy of 211At-SAPS-C6.5 diabody conjugates. The second aim was to develop bispecific-targeting strategies that increase the specificity and efficacy of alpha-emitter-based RAIT. In the performance of the first aim, we created 211At-SAPS-C6.5 diabody conjugates that specifically targeted the HER2 tumor associated antigen. In evaluating these immunoconjugates we determined that they were capable of efficient tumor targeting and therapeutic efficacy of established human tumor xenografts growing in immunodeficient mice. We also determined that therapeutic doses were associated with late renal toxicity, likely due to the role of the kidneys in the systemic elimination o f these agents. We are currently performing more studies focused on better understanding the observed toxicity. In the second aim, we successfully generated bispecific single-chain Fv (bs-scFv) molecules that co-targeted HER2 and HER3 or HER2 and HER4. The in vitro kinetics and in vivo tumor-targeting properties of these molecules were evaluated. These studies revealed that the bs-scFv molecules selectively …

DWPF is considering replacing irregularly shaped glass frit with spherical glass beads in the Slurry Mix Evaporator (SME) process to decrease the yield stress of the melter feed (a non-Newtonian Bingham Plastic). Pilot-scale testing was conducted on spherical glass beads and glass frit to determine how well the glass beads would transfer when compared to the glass frit. Process Engineering Development designed and constructed the test apparatus to aid in the understanding and impacts that spherical glass beads may have on the existing DWPF Frit Transfer System. Testing was conducted to determine if the lines would plug with the glass beads and the glass frit slurry and what is required to unplug the lines. The flow loop consisted of vertical and horizontal runs of clear PVC piping, similar in geometry to the existing system. Two different batches of glass slurry were tested: a batch of 50 wt% spherical glass beads and a batch of 50 wt% glass frit in process water. No chemicals such as formic acid was used in slurry, only water and glass formers. The glass beads used for this testing were commercially available borosilicate glass of mesh size -100+200. The glass frit was Frit 418 obtained from …

The discovery that ultra-intense laser pulses (I > 10{sup 18} W/cm{sup 2}) can produce short pulse, high energy proton beams has renewed interest in the fundamental mechanisms that govern particle acceleration from laser-solid interactions. Experiments have shown that protons present as hydrocarbon contaminants on laser targets can be accelerated up to energies > 50 MeV. Different theoretical models that explain the observed results have been proposed. One model describes a front-surface acceleration mechanism based on the ponderomotive potential of the laser pulse. At high intensities (I > 10{sup 18} W/cm{sup 2}), the quiver energy of an electron oscillating in the electric field of the laser pulse exceeds the electron rest mass, requiring the consideration of relativistic effects. The relativistically correct ponderomotive potential is given by U{sub p} = ([1 + I{lambda}{sup 2}/1.3 x 10{sup 18}]{sup 1/2} - 1) m{sub o}c{sup 2}, where I{lambda}{sup 2} is the irradiance in W {micro}m{sup 2}/cm{sup 2} and m{sub o}c{sup 2} is the electron rest mass. At laser irradiance of I{lambda}{sup 2} {approx} 10{sup 20} W {micro}m{sup 2}/cm{sup 2}, the ponderomotive potential can be of order several MeV. A few recent experiments--discussed in Chapter 3 of this thesis--consider this ponderomotive potential sufficiently strong to accelerate …

wxWindows is an Open Source, platform independent, User Interface (UI) which has been in development for over eleven years (http://www.wxwindows.org). Currently wxWindows is actively supported for the Linux/Unix (X11, Motif and GTK+), Mac OS 9 and X, all Win32 OSes, MGL, and OS/2 operating systems. wxWindows is written in C++ using an object oriented programming framework; it is a reasonably lightweight API (called wxWidgets) sitting over the native graphics packages of the various platforms it supports. The original version of CALE was written for the basic target platform of Unix using X11 as the graphics package. There have been separate efforts to port the code to Mac OS 9, Mac OS X, Win32, Windows Services for Unix (SFU) and CygWin. Each of these used a variety of different graphical interface approaches and build/make systems. For instance Windows SFU and CygWin could still only use X11 graphics. So could the Win32 version, if a X11 server library and client software were installed. A native Win32 version of CALE was contemplated, but never started. The Macintosh versions were completed but never widely distributed to the users. Given the growing code version support issues, and the slow deviation from the portable code model …

Algebraic multigrid (AMG) solvers have proven to be extremely efficient on distributed-memory architectures. However, when executed on modern multicore cluster architectures, we face new challenges that can significantly harm AMG's performance. We discuss our experiences on such an architecture and present a set of techniques that help users to overcome the associated problems, including thread and process pinning and correct memory associations. We have implemented most of the techniques in a MultiCore SUPport library (MCSup), which helps to map OpenMP applications to multicore machines. We present results using both an MPI-only and a hybrid MPI/OpenMP model.

This report discusses a variety of issues pertaining to energy policy. It includes information about most recent developments, background and analysis broken down into major categories, and relevant legislation.

Methods for the numerical discretization of the Vlasov equation should efficiently use the phase space discretization and should introduce only enough numerical dissipation to promote stability and control oscillations. A new high-order, non-linear, finite-volume algorithm for the Vlasov equation that discretely conserves particle number and controls oscillations is presented. The method is fourth-order in space and time in well-resolved regions, but smoothly reduces to a third-order upwind scheme as features become poorly resolved. The new scheme is applied to several standard problems for the Vlasov-Poisson system, and the results are compared with those from other finite-volume approaches, including an artificial viscosity scheme and the Piecewise Parabolic Method. It is shown that the new scheme is able to control oscillations while preserving a higher degree of fidelity of the solution than the other approaches.

The CMS experiment at the CERN Large Hadron Collider is currently being commissioned and is scheduled to collect the first pp collision data in 2008. CMS features a two-level trigger system. The Level-1 trigger, based on custom hardware, is designed to reduce the collision rate of 40 MHz to approximately 100 kHz. Data for events accepted by the Level-1 trigger are read out and assembled by an Event Builder. The High Level Trigger (HLT) employs a set of sophisticated software algorithms, to analyze the complete event information, and further reduce the accepted event rate for permanent storage and analysis. This paper describes the design and implementation of the HLT Configuration Management system. First experiences with commissioning of the HLT system are also reported.

This report is about the 109th Congress which addressed the animal identification and meat traceability. It also points out commercial production and marketing functions, animal health and food safety.

This report considers the Agriculture and Related Agencies appropriations bill. The report compares and contrasts the Senate and House versions of the bill in terms of budgeting. Moreover, both bills reject the termination of the Commodity Supplemental Food Program.

Planar flames are intrinsically unstable in open domains due to the thermal expansion across the burning front--the Landau-Darrieus instability. This instability leads to wrinkling and growth of the flame surface, and corresponding acceleration of the flame, until it is stabilized by cusp formation. We look at the Landau-Darrieus in stability for C/O thermonuclear flames at conditions relevant to the late stages of a Type Ia supernova explosion. Two-dimensional direct numerical simulations of both single-mode and multi-mode perturbations using a low Mach number hydrodynamics code are presented. We show the effect of the instability on the flame speed as a function of both the density and domain size, demonstrate the existence of the small scale cutoff to the growth of the instability, and look for the proposed breakdown of the non-linear stabilization at low densities. The effects of curvature on the flame as quantified through measurements of the growth rate and computation of the corresponding Markstein number. While accelerations of a few percent are observed, they are too small to have any direct outcome on the supernova explosion.

Among the different theoretical approaches able to describe fission, microscopic ones can help us in the understanding of this process, as they have the advantage of describing the nuclear structure and the dynamics in a consistent manner. The sole input of the calculations is the nucleon-nucleon interaction. Such a microscopic time-dependent and quantum mechanical formalism has already been used, based on the Gaussian Overlap Approximation of the Generator Coordinate Method with the adiabatic approximation, to analyze the collective dynamics of low-energy fission in {sup 238}U. However, at higher energies, a few MeV above the barrier, the adiabatic approximation doesn't seem valid anymore. Indeed, manifestations of proton pair breaking have been observed in {sup 238}U and {sup 239}U for an excitation energy of 2.3 MeV above the barrier. Taking the intrinsic excitations into account during the fission process will enable us to determine the coupling between collective and intrinsic degrees of freedom, in particular from saddle to scission. Guidelines of the new formalism under development are presented and some preliminary results on overlaps between non excited and excited states are discussed.

This report focuses on current U.N. reform efforts and priorities from the perspective of several key actors, including the U.S. government, the U.N. Secretary-General, selected groups of member states, non-governmental organizations (NGOs), and a cross-section of groups tasked with addressing U.N. reform. It also examines congressional actions related to U.N. reform, as well as future policy considerations.

This report examines three labor issues and arguments related to the pending U.S.-Colombia free trade agreement (CFTA): violence against trade unionists; impunity (accountability for or punishment of the perpetrators); and worker rights protections for Colombians. This report addresses this issue at length, including the arguments for and against the agreement, as well as general U.S.-Colombia economic relations.

This report examines three labor issues and arguments related to the pending U.S.-Colombia free trade agreement (CFTA): violence against trade unionists; impunity (accountability for or punishment of the perpetrators); and worker rights protections for Colombians. This report addresses this issue at length, including the arguments for and against the agreement, as well as general U.S.-Colombia economic relations.

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The purpose of this report is to describe and discuss the provisions for providing abortion services to military personnel, their dependents, and other military health care beneficiaries at military medical facilities. The report describes the history of these provisions, with particular emphasis on legislative actions. Finally, this report discusses a number of proposals to modify the law, as well as other related legislative and administrative actions.

The purpose of this report is to describe and discuss the provisions for providing abortion services to military personnel, their dependents and other military health care beneficiaries at military medical facilities. The report describes the history of these provisions, with particular emphasis on legislative actions. Finally, this report discusses a number of proposals to modify the Clinton Administration provisions, as well as recently enacted legislation.

Researchers at the Department of Energy's Savannah River Technology Center are using advanced microscopy techniques to understand the effects of trace organic chemical additions on nuclear waste slurry flow properties. Trace organic chemicals, surfactants (rheology modifiers), are being used in all types of industries to modify the flow properties of various commercial chemicals. Nuclear waste treatment at the Department of Energy's weapons production facilities, Savannah River Site and Hanford Reservation, is limited by the viscosity of the nuclear waste slurries as the material is processed through a variety of waste treatment and immobilization processes. The picture was taken using a laser scanning confocal microscope.

This report discusses the AIDS issues in Africa and the Bush administration call to double U.S. international funding for AIDS.

This report reviews the types of air emissions from livestock and poultry operations and their human health and environmental impacts. It then discusses provisions of several federal laws concerned with environmental impacts, beginning with the Clean Water Act, because protecting water resources has been the primary regulatory focus regarding livestock and animal operations.

This report identifies a number of issues that have received attention in connection with water infrastructure investment. It begins with a review of federal involvement, describes the debate about needs, and then examines key issues, including what is the nature of the problems to be solved; who will pay, and what is the federal role; and questions about mechanisms for delivering federal support, including state-by-state allotment of federal funds. Congressional and Administration activity on these issues from the 107th to the 110th Congresses also is reviewed.

This report discusses the phenomenon known as "midnight rulemaking," which refers to the uptick in activity from federal agencies at the end of a presidential administration.

This report discusses about US international HIV/AIDS programs, HIV/AIDS in the foreign operations Appropriations, Labor/HHS Appropriations and other Appropriations.