Agriculture (as measured by share of gross domestic product and employment) is a significant economic sector in seven Central and South Asian countries: Afghanistan, Iran, Kyrgyzstan, Pakistan, Tajikistan, Turkmenistan, and Uzbekistan. All of these countries are net food importers. Some have experienced successive years of drought, which has contributed to noticeable declines in agricultural output and the need to increase commodity imports. The United Nations’ World Food Program reports that both Afghanistan and Tajikistan are currently in need of emergency food assistance to cover sizable food deficits. The food outlook in Afghanistan is made uncertain by ongoing military conflict.

This report discusses the reasons that Iran is considered a threat to U.S. security, including Iran's nuclear program, involvement with terrorist organizations, and involvement with neighboring countries' local governments. The report also discusses ways which the U.S. hopes to modify Iran's behavior with sanctions, and the effectiveness of these sanctions.

Iran is materially assisting and attempting to influence, in most cases against the United States, major Shiite Muslim factions in Iraq, most of which have ideological, political, and religious ties to Tehran. The Administration asserts that Tehran is actively directing, training, and arming Shiite militiamen linked, to varying degrees, to hardline anti-U.S. cleric Moqtada Al Sadr. Some analysts see a virtual "proxy war" between the United States and Iran inside Iraq.