Breast cancer is predominantly a disease of the genome with cancers arising and progressing through accumulation of aberrations that alter the genome - by changing DNA sequence, copy number, and structure in ways that that contribute to diverse aspects of cancer pathophysiology. Classic examples of genomic events that contribute to breast cancer pathophysiology include inherited mutations in BRCA1, BRCA2, TP53, and CHK2 that contribute to the initiation of breast cancer, amplification of ERBB2 (formerly HER2) and mutations of elements of the PI3-kinase pathway that activate aspects of epidermal growth factor receptor (EGFR) signaling and deletion of CDKN2A/B that contributes to cell cycle deregulation and genome instability. It is now apparent that accumulation of these aberrations is a time-dependent process that accelerates with age. Although American women living to an age of 85 have a 1 in 8 chance of developing breast cancer, the incidence of cancer in women younger than 30 years is uncommon. This is consistent with a multistep cancer progression model whereby mutation and selection drive the tumor's development, analogous to traditional Darwinian evolution. In the case of cancer, the driving events are changes in sequence, copy number, and structure of DNA and alterations in chromatin structure or …

Financial reports compiled by the Texas Department of Criminal Justice documenting the agency's operating budget during fiscal year 2007 and funding requests for the 2008-2009 biennium, submitted to the Texas Board of Criminal Justice for consideration.

A legislative appropriation request for the biennium 2008-2009, in order to provide more effective claims administration and risk management services and ultimately result in savings to state agencies in the form of reduced workers' compensation claims and costs, reduced insurance purchases and improved insurance coverages, and more effective risk management programs.

Base Visit Trip Report - Defense Finance and Accounting Center (DFAS) Denver, CO on 3 Aug 2005

Base Visit Trip Report - Defense Finance and Accounting Center (DFAS) Indianapolis, IN 3 Aug 2005 - Presentation DFAS BRAC Update

To quantify metal natural attenuation processes in terms of environmental availability, sequential extraction experiments were carried out on subsurface soil samples impacted by a low pH, high sulfate, metals (Be, Ni, U, As) plume associated with the long-term operation of a coal plant at the Savannah River Site in South Carolina. Despite significant heterogeneity resulting both from natural and anthropogenic factors, sequential extraction results demonstrate that pH is a controlling factor in the prediction of the distribution of metal contaminants within the solid phases in soils at the site as well as the contaminant partitioning between the soil and the soil solution. Results for beryllium, the most mobile metal evaluated, exhibit increasing attenuation along the plume flow path which corresponds to an increasing plume pH. These laboratory- and field-scale studies provide mechanistic information regarding partitioning of metals to soils at the site (one of the major attenuation mechanisms for the metals at the field site). Subsequently, these data have been used in the definition of the contaminant source terms and contaminant transport factors in risk modeling for the site.

The Yang-Mills theory lies at the heart of our understanding of elementary particle interactions. For the strong nuclear forces, we must understand this theory in the strong coupling regime. The primary technique for this is the lattice. While basically an ultraviolet regulator, the lattice avoids the use of a perturbative expansion. I discuss some of the historical circumstances that drove us to this approach, which has had immense success, convincingly demonstrating quark confinement and obtaining crucial properties of the strong interactions from first principles.

A legislative appropriation request for the biennium 2004-2005, in order to provide more effective claims administration and risk management services and ultimately result in savings to state agencies in the form of reduced workers' compensation claims and costs, reduced insurance purchases and improved insurance coverages, and more effective risk management programs.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the circuit board manufacturer (Sanmina Plant) project.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the plastics blow molding plant project.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the textile manufacturing mill project.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the Caterpillar's Pontiac Plant project.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the food processing facility project.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the steel mill project.

A tri-fold brochure addressing energy-saving tips for homeowners ranging from low- or no-cost suggestions to higher cost suggestions for longer-term savings. Cooling, windows, weatherizing, and landscaping are addressed.

Minimizing your blowdown rate can substantially reduce energy losses, as the temperature of the blown-down liquid is the same as that of the steam generated in the boiler.

This case study is one in a series on industrial firms who are implementing energy efficient technologies and system improvements into their manufacturing processes. This case study documents the activities, savings, and lessons learned on the Bodine Electric motor assembly plant project.

Heat can be recovered from boiler blowdown by using a heat exchanger to preheat boiler makeup water.

All industrial facilities have a network of piping that carries water or other liquids. 16% of a typical facility's electricity costs are for its pumping systems.

An attractive method of improving your power plant's energy efficiency is to increase the condensate return to the boiler.

New houses designed by Ideal Homes, with technical support from the U.S. Department of Energy's Building America Program, save their homeowners money by applying the principles of ''whole-building'' design. The homes are in Norman, Oklahoma.

A quarterly magazine with articles on recent changes to the Clean Cities Program; the SuperTruck student engineering challenge; alternative fuel use in delivery fleets; and a propane vehicle rally and conference in February 2001, in Kansas City, Mo.

Taking an Alternative Route is a 30-page guide for fleet managers and individual owners on using alternative fuels in cars and trucks. Discussed in detail are all fuels authorized for federal credits under the Energy Policy Act of 1992 (EPAct). The publication informs federal and state fleet managers about how to comply with EPAct, and provides information about the Clean Air Act Amendments.

The Inventions and Innovation Program, formerly known as ERIP (Energy-related Inventions Program), was established by the U.S. Congress in 1974. The program offers assistance to independent inventors and very small businesses engaged in developing new energy-saving technologies. The program remains clearly focused on energy generation and savings. The I&I Program funding is based on a competitive proposal process.