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Experimental development of nuclear pumped laser candidate inertial confinement fusion driver
This progress report is submitted at the end of the first year of a 3-year project grant studying development of a nuclear pumped atomic iodine laser. The first section of the report will provide background on the study and briefly describe the original plans for the 3-year project. The second section will detail the work done to date. Included will be a description of the preparations made for experimentation, as well as some preliminary results recently obtained. Plans for the upcoming budget year are covered in the accompanying proposal, Project Plans for 1989--1990.''
Date:
May 31, 1989
Creator:
Miley, George H.
System:
The UNT Digital Library
Toxicology Studies of Lewisite and Sulfur Mustard Agents: Genetic Toxicity of Lewisite (L) In Chinese Hamster Ovary Cells
The cytotoxic clastogenic and mutagenic effects of the arsenic containing vesicant, Lewisite (L) [dichloro(2-chlorovinyl) arsine], have been investigated using Chinese hamster ovary cells. One hour exposures to Lewisite were cytotoxic in uM amounts. The cell survival response yields a D37 of 0.6 uM and an extrapolation number of 2.5. The mutagenic response at the hypoxantnine-guanine phosporibosyl transferase (HGPRT) locus was sporadic and not significantly greater than control values when cells were exposed over a range of 0.125 to2.0 uM. Sister chromatid exchange (SCE) induction, a measure of chromosomal rearrangement, was weakly positive over a range of 0.25 to 1.0 uM but the values were not significantly greater than the control response. Chromosomal aberrations were induced at 0.75 and 1.0 UMin one experiment and 0.5 and 0.75 uM in another experiment. The Induced values were significantly greater than the control values. Lewisite appears to be cytotoxic and clastogenic in our investigations but SCE and mutation at the HGPRT locus are not significantly greater than control values. Lewisita toxicity was in some ways similar to radiomimetic chemicals such as bleomycin.
Date:
May 31, 1989
Creator:
Jostes Jr., R. F.; Sasser, L. B. & Rausch, R. J.
System:
The UNT Digital Library
Experimental development of nuclear pumped laser candidate inertial confinement fusion driver. Technical progress report, Phase 1, 1988--1989
This progress report is submitted at the end of the first year of a 3-year project grant studying development of a nuclear pumped atomic iodine laser. The first section of the report will provide background on the study and briefly describe the original plans for the 3-year project. The second section will detail the work done to date. Included will be a description of the preparations made for experimentation, as well as some preliminary results recently obtained. Plans for the upcoming budget year are covered in the accompanying proposal, ``Project Plans for 1989--1990.``
Date:
May 31, 1989
Creator:
Miley, G. H.
System:
The UNT Digital Library