Genomes of hundreds of species have been sequenced to date, and many more are being sequenced. As more and more sequence data sets become available, and as the challenge of comparing these massive ''billion basepair DNA sequences'' becomes substantial, so does the need for more powerful tools supporting the exploration of these data sets. Similarity score data used to compare aligned DNA sequences is inherently one-dimensional. One-dimensional (1D) representations of these data sets do not effectively utilize screen real estate. As a result, tools using 1D representations are incapable of providing informatory overview for extremely large data sets. We present a technique to arrange 1D data in 3D space to allow us to apply state-of-the-art interactive volume visualization techniques for data exploration. We demonstrate our technique using multi-millions-basepair-long aligned DNA sequence data and compare it with traditional 1D line plots. The results show that our technique is superior in providing an overview of entire data sets. Our technique, coupled with 1D line plots, results in effective multi-resolution visualization of very large aligned sequence data sets.

This account of the beginning of the program on laser fusion at Livermore in 1962, and its subsequent development during the decade ending in 1972, was originally prepared as a contribution to the January 1991 symposium 'Achievements in Physics' honoring Professor Keith Brueckner upon his retirement from the University of San Diego at La Jolla. It is a personal recollection of work at Livermore from my vantage point as its scientific leader, and of events elsewhere that I thought significant. This period was one of rapid growth in which the technology of high-power short-pulse lasers needed to drive the implosion of thermonuclear fuel to the temperature and density needed for ignition was developed, and in which the physics of the interaction of intense light with plasmas was explored both theoretically and experimentally.

Nuclear Medicine is the specialty of medical imaging, which utilizes a variety of radionuclides incorporated into specific compounds for diagnostic imaging and therapeutic applications. During recent years, research efforts associated with this discipline have concentrated on the decay characteristics of particular radionuclides and the design of unique radiolabeled tracers necessary to achieve time-dependent molecular images. The specialty is expanding with specific Positron emission tomography (PET) and SPECT radiopharmaceuticals allowing for an extension from functional process imaging in tissue to pathologic processes and nuclide directed treatments. PET is an example of a technique that has been shown to yield the physiologic information necessary for clinical oncology diagnoses based upon altered tissue metabolism. Most PET drugs are currently produced using a cyclotron at locations that are in close proximity to the hospital or academic center at which the radiopharmaceutical will be administered. In November 1997, a law was enacted called the Food and Drug Administration Modernization Act of 1997 which directed the Food and Drug Administration (FDA) to establish appropriate procedures for the approval of PET drugs in accordance with section 505 of the Federal Food, Drug, and Cosmetic Act and to establish current good manufacturing practice requirements for such drugs. At …

Project fact sheet written for the Inventions and Innovation Program about an advanced analysis method that provides complete on-line ultrasonic inspection of tubular materials.

Project fact sheet written for the Inventions and Innovation Program about a new technology that increases load-leveling efficiency and offers longer cycle life than lead-acid batteries.

Fact sheet written for the NICE3 Program on a new process that creates a corrosion-resistant coating for recuperators.

Project fact sheet written for the Inventions and Innovation Program about an innovative technology for predicting and avoiding liquid and jet flooding in the petroleum refining process.

Project fact sheet written for the Inventions and Innovation Program about a new dual fuel conversion system allows diesel fuel switching with clean burning natural gas.

Project fact sheet written for the Inventions and Innovation Program about a new process to produce ethylene more efficiently.

Project fact sheet written for the Inventions and Innovation Program about a rapid-prototyping process that improves investment casting technologies by repositioning cooling channels.

Fact sheet written for the NICE3 Program on a new process that improves the efficiency and productivity of die casting operations.

The Laboratory Coordinating Council, working through OIT, coordinates partnerships between industry, academia, and the 16 U.S. national laboratories and facilities.

Project fact sheet written for the Inventions and Innovation Program about a new mechanochemical process that delivers titanium-carbide powder for cutting-tool fabrication.

Project fact sheet written for the Inventions and Innovation Program about an innovative device that uses acoustic energy to enhance productivity in mixing equipment.

Fact sheet written for the NICE3 Program on a new magnetic elutriation technology for mining that offers waste, energy, and economic savings.

Project fact sheet written for the Inventions and Innovation Program about a new miniature oxygen sensor that costs less that conventional sensors.

Project fact sheet written for the Inventions and Innovation Program about an advanced laser technology that safely detects leaks and emissions without requiring an air sample.

Project fact sheet written for the Inventions and Innovation Program about a self-agitating soap stick that removes accumulated water from water logged natural gas wells.

Fact sheet written for the NICE3 Program on an innovative method of purifying combinatorial chemistry compounds.

Fact sheet written for the NICE3 Program on a new technology that separates gas, oil, and water from offshore oil and gas operations.

This 16-page brochure, including 9 one-page inserts, provides an overview of the Office of Industrial Technologies and its research, development, and deployment efforts to increase industrial energy efficiency.

Waste Management, Inc., began operating a fleet of heavy-duty LNG refuse trucks at its Washington, Pennsylvania, facility. The objective of the project was to provide transportation professionals with quantitative, unbiased information on the cost, maintenance, operational, and emissions characteristics of LNG as one alternative to conventional diesel for heavy-duty trucking applications.

Ethanol made from biomass, or bioethanol, can positively impact the national energy security, the economy, and the environment. Producing and using bioethanol can help alleviate some of the negative impacts of the dependence on fossil fuels.

The AR Windamper System was developed through a grant from the Inventions and Innovation Program, to protect power transmission lines in sleet belt states and provinces by eliminating the ''galloping'' phenomenon. Wind damping products minimize power outages and reduce repair costs to transmission lines.