This Institutional Plan for FY 2004-2008 is the principal annual planning document submitted to the Department of Energy's Office of Science by Pacific Northwest National Laboratory in Richland, Washington. This plan describes the Laboratory's mission, roles, and technical capabilities in support of Department of Energy priorities, missions, and plans. It also describes the Laboratory strategic plan, key planning assumptions, major research initiatives, and program strategy for fundamental science, energy resources, environmental quality, and national security.

Stroke is a major cause of mortality and is the primary cause of long-term disability in the United States. A recent study of Stroke incidence, using conservative calculations, suggests that over 700,000 people annually in this country will have a stroke. Of these 700,000, approximately 150,000 will die and 400,000 will be left with a significant deficit; only one quarter will return to an independent--although not necessarily baseline--level of functioning. The costs of caring for victims of stroke in the acute phase, chronic care, and lost productivity amount to 40 billion per year. Of all strokes, approximately 20% are hemorrhagic and 20% are due to small vessel disease. Thus, the number of people with large vessel thromboembolic disease and the target population of this research is greater than 400,000. Currently, the only approved therapy for treatment of acute ischemic stroke is intravenous thrombolytic drugs. While stroke patients who receive these drugs are more likely to have better outcomes than those who do not, their improvement is highly dependent on the initiation of treatment within three hours of the onset of symptoms, with an increased risk of intracranial hemorrhage if the medication is begun outside this time window. With this rigid …

This report covers the work completed during Year One (Year One has a 16 month project period) of a five- year Cooperative Agreement (DE-FC26-03NT41895) between the International Union of Operating Engineers (IUOE) National Hazmat Program (OENHP) and the U. S. Department of Energy (DOE) National Energy Technology Laboratory (NETL). This final technical report is being submitted, as required by the Cooperative Agreement, within 90 (calendar) days after the project period ends (December 31, 2004). The resources allocated to Year One of the Cooperative Agreement were adequate for the completion of the required deliverables. All deliverables have been completed and sent to AAD Document Control as directed in the cooperative agreement. The allocation for Year One required 20-25 trainers to be trained in each of five Train-the-Trainer courses and a total of 6,000 workers trained throughout the country. Through cost savings employed for the scheduling and conduct of Train-the-Trainer, instructor refreshers, and direct training classes, 3171 workers have been trained to date. This total incorporates 159 trainers and members from management, local, county, state and federal organizations identified in the Strategic Plan. The largest percentage of personnel trained is heavy equipment operators, and building engineers, which is the largest targeted population …