Dry Deposition Velocity Estimation for the Savannah River Site: Part 1 – Parametric Analysis (open access)

Dry Deposition Velocity Estimation for the Savannah River Site: Part 1 – Parametric Analysis

Values for the dry deposition velocity of airborne particles were estimated with the GENII Version 2.10 computer code for the Savannah River site using assumptions about surface roughness parameters and particle size and density. Use of the GENII code is recommended by the U.S. Department of Energy for this purpose. Meteorological conditions evaluated include atmospheric stability classes D, E, and F and wind speeds of 0.5, 1.0, 1.5, and 3.0 m/s. Local surface roughness values ranging from 0.03 to 2 meters were evaluated. Particles with mass mean diameters of 1, 5, and 10 microns and densities of 1, 3, and 5 g/cm3 were evaluated.
Date: January 16, 2012
Creator: Napier, Bruce A.
Object Type: Report
System: The UNT Digital Library
AdS/QCD and Applications of Light-Front Holography (open access)

AdS/QCD and Applications of Light-Front Holography

Light-Front Holography leads to a rigorous connection between hadronic amplitudes in a higher dimensional anti-de Sitter (AdS) space and frame-independent light-front wavefunctions of hadrons in 3 + 1 physical space-time, thus providing a compelling physical interpretation of the AdS/CFT correspondence principle and AdS/QCD, a useful framework which describes the correspondence between theories in a modified AdS5 background and confining field theories in physical space-time. To a first semiclassical approximation, where quantum loops and quark masses are not included, this approach leads to a single-variable light-front Schroedinger equation which determines the eigenspectrum and the light-front wavefunctions of hadrons for general spin and orbital angular momentum. The coordinate z in AdS space is uniquely identified with a Lorentz-invariant coordinate {zeta} which measures the separation of the constituents within a hadron at equal light-front time. The internal structure of hadrons is explicitly introduced and the angular momentum of the constituents plays a key role. We give an overview of the light-front holographic approach to strongly coupled QCD. In particular, we study the photon-to-meson transition form factors (TFFs) F{sub M{gamma}}(Q{sup 2}) for {gamma}{gamma}* {yields} M using light-front holographic methods. The results for the TFFs for the {eta} and {eta}' mesons are also presented. Some …
Date: February 16, 2012
Creator: Brodsky, Stanley J.; /SLAC /Southern Denmark U., CP3-Origins; Cao, Fu-Guang; U., /Massey; de Teramond, Guy F. & U., /Costa Rica
Object Type: Article
System: The UNT Digital Library
AdS/QCD, Light-Front Holography, and Sublimated Gluons (open access)

AdS/QCD, Light-Front Holography, and Sublimated Gluons

The gauge/gravity duality leads to a simple analytical and phenomenologically compelling nonperturbative approximation to the full light-front QCD Hamiltonian - 'Light-Front Holography', which provides a Lorentz-invariant first-approximation to QCD, and successfully describes the spectroscopy of light-quark meson and baryons, their elastic and transition form factors, and other hadronic properties. The bound-state Schroedinger and Dirac equations of the soft-wall AdS/QCD model predict linear Regge trajectories which have the same slope in orbital angular momentum L and radial quantum number n for both mesons and baryons. Light-front holography connects the fifth-dimensional coordinate of AdS space z to an invariant impact separation variable {zeta} in 3+1 space at fixed light-front time. A key feature is the determination of the frame-independent light-front wavefunctions of hadrons - the relativistic analogs of the Schroedinger wavefunctions of atomic physics which allow one to compute form factors, transversity distributions, spin properties of the valence quarks, jet hadronization, and other hadronic observables. One thus obtains a one-parameter color-confining model for hadron physics at the amplitude level. AdS/QCD also predicts the form of the non-perturbative effective coupling {alpha}{sub s}{sup AdS} (Q) and its {beta}-function with an infrared fixed point which agrees with the effective coupling a{sub g1} (Q{sup 2}) extracted …
Date: February 16, 2012
Creator: Brodsky, Stanley J. & de Teramond, Guy F.
Object Type: Article
System: The UNT Digital Library
ADVANCED COMPOSITE WIND TURBINE BLADE DESIGN BASED ON DURABILITY AND DAMAGE TOLERANCE (open access)

ADVANCED COMPOSITE WIND TURBINE BLADE DESIGN BASED ON DURABILITY AND DAMAGE TOLERANCE

The objective of the program was to demonstrate and verify Certification-by-Analysis (CBA) capability for wind turbine blades made from advanced lightweight composite materials. The approach integrated durability and damage tolerance analysis with robust design and virtual testing capabilities to deliver superior, durable, low weight, low cost, long life, and reliable wind blade design. The GENOA durability and life prediction software suite was be used as the primary simulation tool. First, a micromechanics-based computational approach was used to assess the durability of composite laminates with ply drop features commonly used in wind turbine applications. Ply drops occur in composite joints and closures of wind turbine blades to reduce skin thicknesses along the blade span. They increase localized stress concentration, which may cause premature delamination failure in composite and reduced fatigue service life. Durability and damage tolerance (D&DT) were evaluated utilizing a multi-scale micro-macro progressive failure analysis (PFA) technique. PFA is finite element based and is capable of detecting all stages of material damage including initiation and propagation of delamination. It assesses multiple failure criteria and includes the effects of manufacturing anomalies (i.e., void, fiber waviness). Two different approaches have been used within PFA. The first approach is Virtual Crack Closure Technique …
Date: February 16, 2012
Creator: Abumeri, Galib & Abdi, Frank
Object Type: Report
System: The UNT Digital Library
Air Traffic Control Modernization: Management Challenges Associated with Program Costs and Schedules Could Hinder NextGen Implementation (open access)

Air Traffic Control Modernization: Management Challenges Associated with Program Costs and Schedules Could Hinder NextGen Implementation

A letter report issued by the Government Accountability Office with an abstract that begins "In a review of 30 major ATC acquisition programs, all of which will contribute to the transition to NextGen, GAO found that costs for 11 of the 30 programs have increased from their initial estimates by a total of $4.2 billion and 15 programs experienced delays. The 11 acquisitions that experienced cost increases account for over 60 percent of FAA’s total acquisition costs ($11 billion of $17.7 billion) for the 30 programs. The 15 acquisitions that experienced schedule delays, of which 10 also had cost increases, ranged from 2 months to more than 14 years and averaged 48 months."
Date: February 16, 2012
Creator: United States. Government Accountability Office.
Object Type: Report
System: The UNT Digital Library
Analytic Coleman-de Luccia Geometries (open access)

Analytic Coleman-de Luccia Geometries

We present the necessary and sufficient conditions for a Euclidean scale factor to be a solution of the Coleman-de Luccia equations for some analytic potential V ({psi}), with a Lorentzian continuation describing the growth of a bubble of lower-energy vacuum surrounded by higher-energy vacuum. We then give a set of explicit examples that satisfy the conditions and thus are closed-form analytic examples of Coleman-de Luccia geometries.
Date: February 16, 2012
Creator: Dong, Xi; /Stanford U., ITP /Stanford U., Phys. Dept. /SLAC; Harlow, Daniel & /Stanford U., ITP /Stanford U., Phys. Dept.
Object Type: Article
System: The UNT Digital Library
Atoms in Flight: The Remarkable Connections between Atomic and Hadronic Physics (open access)

Atoms in Flight: The Remarkable Connections between Atomic and Hadronic Physics

Atomic physics and hadron physics are both based on Yang Mills gauge theory; in fact, quantum electrodynamics can be regarded as the zero-color limit of quantum chromodynamics. I review a number of areas where the techniques of atomic physics provide important insight into the theory of hadrons in QCD. For example, the Dirac-Coulomb equation, which predicts the spectroscopy and structure of hydrogenic atoms, has an analog in hadron physics in the form of light-front relativistic equations of motion which give a remarkable first approximation to the spectroscopy, dynamics, and structure of light hadrons. The renormalization scale for the running coupling, which is unambiguously set in QED, leads to a method for setting the renormalization scale in QCD. The production of atoms in flight provides a method for computing the formation of hadrons at the amplitude level. Conversely, many techniques which have been developed for hadron physics, such as scaling laws, evolution equations, and light-front quantization have equal utility for atomic physics, especially in the relativistic domain. I also present a new perspective for understanding the contributions to the cosmological constant from QED and QCD.
Date: February 16, 2012
Creator: Brodsky, Stanley J.
Object Type: Article
System: The UNT Digital Library
Building Cooling and Air Conditioning (open access)

Building Cooling and Air Conditioning

Advanced Research Projects Agency-Energy project sheet summarizing general information about the 15 projects that are a part of the Building Energy Efficiency Through Innovative Thermodevices (BEETIT) program including project goals, innovation needs, and potential impacts.
Date: February 16, 2012
Creator: United States. Advanced Research Projects Agency-Energy.
Object Type: Text
System: The UNT Digital Library
CALIBRATION OF X-RAY IMAGING DEVICES FOR ACCURATE INTENSITY MEASUREMENT (open access)

CALIBRATION OF X-RAY IMAGING DEVICES FOR ACCURATE INTENSITY MEASUREMENT

National Security Technologies (NSTec) has developed calibration procedures for X-ray imaging systems. The X-ray sources that are used for calibration are both diode type and diode/fluorescer combinations. Calibrating the X-ray detectors is key to accurate calibration of the X-ray sources. Both energy dispersive detectors and photodiodes measuring total flux were used. We have developed calibration techniques for the detectors using radioactive sources that are traceable to the National Institute of Standards and Technology (NIST). The German synchrotron at Physikalische Technische Bundestalt (PTB) is used to calibrate silicon photodiodes over the energy range from 50 eV to 60 keV. The measurements on X-ray cameras made using the NSTec X-ray sources have included quantum efficiency averaged over all pixels, camera counts per photon per pixel, and response variation across the sensor. The instrumentation required to accomplish the calibrations is described. X-ray energies ranged from 720 eV to 22.7 keV. The X-ray sources produce narrow energy bands, allowing us to determine the properties as a function of X-ray energy. The calibrations were done for several types of imaging devices. There were back illuminated and front illuminated CCD (charge coupled device) sensors, and a CID (charge injection device) type camera. The CCD and CID …
Date: February 16, 2012
Creator: Haugh, M. J.; Charest, M. R.; Ross, P. W.; Lee, J. J.; Schneider, M. B.; Palmer, N. E. et al.
Object Type: Article
System: The UNT Digital Library
Defined Benefit Pension Plans: Recent Developments Highlight Challenges of Hedge Fund and Private Equity Investing (open access)

Defined Benefit Pension Plans: Recent Developments Highlight Challenges of Hedge Fund and Private Equity Investing

A letter report issued by the Government Accountability Office with an abstract that begins "While plan representatives GAO contacted generally stated that their hedge fund and private equity investments met expectations in recent years, a number of plans experienced losses and other challenges, such as limited liquidity and transparency. National data indicated that hedge fund and private equity investments were significantly affected by the 2008-2009 financial crisis, and plans and experts GAO contacted indicated that pension plan investments were not insulated from losses. Most of the 22 plan representatives GAO interviewed said that their hedge fund investments met expectations overall, despite, in some cases, significant losses during the financial crisis. A few plan representatives, however, expected hedge fund investments to be much more resilient in turbulent markets, and found the losses disappointing. Given the long-term nature of private equity investments, almost all of the representatives were generally satisfied with these investments over the last 5 years. Some plan representatives described significant difficulties in hedge fund and private equity investing related to limited liquidity and transparency, and the negative impact of the actions of other investors in the fund—sometimes referred to as co-investors. For example, representatives from one plan reported they …
Date: February 16, 2012
Creator: United States. Government Accountability Office.
Object Type: Report
System: The UNT Digital Library
Elementary Steps of Syngas Reactions on Mo2C(001): Adsorption Thermochemistry and Bond Dissociation (open access)

Elementary Steps of Syngas Reactions on Mo2C(001): Adsorption Thermochemistry and Bond Dissociation

Density functional theory (DFT) and ab initio thermodynamics are applied in order to investigate the most stable surface and subsurface terminations of Mo{sub 2}C(001) as a function of chemical potential and in the presence of syngas. The Mo-terminated (001) surface is then used as a model surface to evaluate the thermochemistry and energetic barriers for key elementary steps in syngas reactions. Adsorption energy scaling relations and Broensted-Evans-Polanyi relationships are established and used to place Mo{sub 2}C into the context of transition metal surfaces. The results indicate that the surface termination is a complex function of reaction conditions and kinetics. It is predicted that the surface will be covered by either C{sub 2}H{sub 2} or O depending on conditions. Comparisons to transition metals indicate that the Mo-terminated Mo{sub 2}C(001) surface exhibits carbon reactivity similar to transition metals such as Ru and Ir, but is significantly more reactive towards oxygen.
Date: February 16, 2012
Creator: Medford, Andrew
Object Type: Article
System: The UNT Digital Library
Emergent Phenomena at Oxide Interfaces (open access)

Emergent Phenomena at Oxide Interfaces

Transition metal oxides (TMOs) are an ideal arena for the study of electronic correlations because the s-electrons of the transition metal ions are removed and transferred to oxygen ions, and hence the strongly correlated d-electrons determine their physical properties such as electrical transport, magnetism, optical response, thermal conductivity, and superconductivity. These electron correlations prohibit the double occupancy of metal sites and induce a local entanglement of charge, spin, and orbital degrees of freedom. This gives rise to a variety of phenomena, e.g., Mott insulators, various charge/spin/orbital orderings, metal-insulator transitions, multiferroics, and superconductivity. In recent years, there has been a burst of activity to manipulate these phenomena, as well as create new ones, using oxide heterostructures. Most fundamental to understanding the physical properties of TMOs is the concept of symmetry of the order parameter. As Landau recognized, the essence of phase transitions is the change of the symmetry. For example, ferromagnetic ordering breaks the rotational symmetry in spin space, i.e., the ordered phase has lower symmetry than the Hamiltonian of the system. There are three most important symmetries to be considered here. (i) Spatial inversion (I), defined as r {yields} -r. In the case of an insulator, breaking this symmetry can …
Date: February 16, 2012
Creator: Hwang, H.Y.
Object Type: Report
System: The UNT Digital Library
F-35 Joint Strike Fighter (JSF) Program (open access)

F-35 Joint Strike Fighter (JSF) Program

The F-35 Joint Strike Fighter (JSF), also called the Lighting II, is a new strike fighter being procured in different versions by the Air Force, Marine Corps, and Navy. The F-35 program is the Department of Defense's (DOD's) largest weapon procurement program in terms of total estimated acquisition cost. This report details the Obama Administration's proposed FY2010 defense budget requests for F-35 program funding and outlines the issues that Congress must consider when deciding whether to approve, reject, or modify the administration's funding requests.
Date: February 16, 2012
Creator: Gertler, Jeremiah
Object Type: Report
System: The UNT Digital Library
Health Insurance: A Primer (open access)

Health Insurance: A Primer

This report provides information related to health insurance. The content includes what it is, why is it needed, health insurance regulation, and how are private health benefits delivered and financed.
Date: February 16, 2012
Creator: Fernandez, Bernadette
Object Type: Report
System: The UNT Digital Library
High-Efficiency Solid State Cooling Technologies (open access)

High-Efficiency Solid State Cooling Technologies

Advanced Research Projects Agency-Energy project sheet summarizing general information about the Building Energy Efficiency Through Innovative Thermodevices (BEETIT) program including critical needs, innovation and advantages, impacts, and contact information. This sheet discusses air conditioning that would be more efficient and not use polluting refrigerants as part of the "Non-Equilibrium Asymmetic Thermoelectrics (NEAT) Devices" project.
Date: February 16, 2012
Creator: Sheetak, Inc.
Object Type: Text
System: The UNT Digital Library
The Impact of Intrinsic Heavy Quark Distributions in the Proton on New Physics Searches at the High Intensity Frontier (open access)

The Impact of Intrinsic Heavy Quark Distributions in the Proton on New Physics Searches at the High Intensity Frontier

The possibility of an intense proton facility, at 'Project X' or elsewhere, will provide many new opportunities for searches for physics beyond the Standard Model. A Project X can serve a yet broader role in the search for new physics, and in this note we highlight the manner in which thus-enabled studies of the flavor structure of the proton, particularly of its intrinsic heavy quark content, facilitate other direct and indirect searches for new physics. Intrinsic heavy quarks in both light and heavy hadrons play a key role in searches for physics BSM with hadrons - and their study at the Intensity Frontier may prove crucial to establishing its existence.
Date: February 16, 2012
Creator: Brodsky, Stanley & Gardner, Susan
Object Type: Article
System: The UNT Digital Library
The Impact of SuperB on Flavor Physics (open access)

The Impact of SuperB on Flavor Physics

This report provides a succinct summary of the physics programme of SuperB, and describes that potential in the context of experiments making measurements in flavour physics over the next 10 to 20 years. Detailed comparisons are made with Belle II and LHCb, the other B physics experiments that will run in this decade. SuperB will play a crucial role in defining the landscape of flavour physics over the next 20 years. SuperB is an approved high luminosity e{sup +}e{sup -} collider intended to search for indirect and some direct signs of new physics (NP) at low energy, while at the same time, enabling precision tests of the Standard Model (SM). This experiment will be built at a new laboratory on the Tor Vergata campus near Rome, Italy named after Nicola Cabibbo. The project has been described in a Conceptual Design Report, and more recently by a set of three white papers on the accelerator, detector, and physics programme. The main focus of the physics programme rests in the study of so-called Golden Modes, these are decay channels that provide access to measurements of theoretically clean observables that can provide both stringent constraints on models of NP, and precision tests of …
Date: February 16, 2012
Creator: Meadows, B.; Blanke, M.; Stocchi, A.; Drutskoy, A.; Cervelli, A.; Giorgi, M. et al.
Object Type: Report
System: The UNT Digital Library
Light-Front Holographic QCD (open access)

Light-Front Holographic QCD

The relation between the hadronic short-distance constituent quark and gluon particle limit and the long-range confining domain is yet one of the most challenging aspects of particle physics due to the strong coupling nature of Quantum Chromodynamics, the fundamental theory of the strong interactions. The central question is how one can compute hadronic properties from first principles; i.e., directly from the QCD Lagrangian. The most successful theoretical approach thus far has been to quantize QCD on discrete lattices in Euclidean space-time. Lattice numerical results follow from computation of frame-dependent moments of distributions in Euclidean space and dynamical observables in Minkowski spacetime, such as the time-like hadronic form factors, are not amenable to Euclidean lattice computations. The Dyson-Schwinger methods have led to many important insights, such as the infrared fixed point behavior of the strong coupling constant, but in practice, the analyses are limited to ladder approximation in Landau gauge. Baryon spectroscopy and the excitation dynamics of nucleon resonances encoded in the nucleon transition form factors can provide fundamental insight into the strong-coupling dynamics of QCD. New theoretical tools are thus of primary interest for the interpretation of the results expected at the new mass scale and kinematic regions accessible to …
Date: February 16, 2012
Creator: Brodsky, Stanley J.; /SLAC /Southern Denmark U., CP3-Origins; de Teramond, Guy F. & U., /Costa Rica
Object Type: Article
System: The UNT Digital Library
Light-Front Holography, Light-Front Wavefunctions, and Novel QCD Phenomena (open access)

Light-Front Holography, Light-Front Wavefunctions, and Novel QCD Phenomena

Light-Front Holography is one of the most remarkable features of the AdS/CFT correspondence. In spite of its present limitations it provides important physical insights into the nonperturbative regime of QCD and its transition to the perturbative domain. This novel framework allows hadronic amplitudes in a higher dimensional anti-de Sitter (AdS) space to be mapped to frame-independent light-front wavefunctions of hadrons in physical space-time. The model leads to an effective confining light-front QCD Hamiltonian and a single-variable light-front Schroedinger equation which determines the eigenspectrum and the light-front wavefunctions of hadrons for general spin and orbital angular momentum. The coordinate z in AdS space is uniquely identified with a Lorentz-invariant coordinate {zeta} which measures the separation of the constituents within a hadron at equal light-front time and determines the off-shell dynamics of the bound-state wavefunctions, and thus the fall-off as a function of the invariant mass of the constituents. The soft-wall holographic model modified by a positive-sign dilaton metric, leads to a remarkable one-parameter description of nonperturbative hadron dynamics - a semi-classical frame-independent first approximation to the spectra and light-front wavefunctions of meson and baryons. The model predicts a Regge spectrum of linear trajectories with the same slope in the leading orbital …
Date: February 16, 2012
Creator: Brodsky, Stanley J.; /SLAC /Southern Denmark U., CP3-Origins; de Teramond, Guy F. & U., /Costa Rica
Object Type: Article
System: The UNT Digital Library
National Nuclear Security Administration: Observations on NNSA's Management and Oversight of the Nuclear Security Enterprise (open access)

National Nuclear Security Administration: Observations on NNSA's Management and Oversight of the Nuclear Security Enterprise

Testimony issued by the Government Accountability Office with an abstract that begins "NNSA has successfully ensured that the nuclear weapons stockpile remains safe and reliable in the absence of underground nuclear testing, accomplishing this complicated task by using state-of-the-art facilities as well as the skills of top scientists. Nevertheless, NNSA does not have reliable enterprise-wide management information on program budgets and costs, which potentially increases risk to NNSA’s programs. For example, in June 2010, GAO reported that NNSA could not identify the total costs to operate and maintain essential weapons activities facilities and infrastructure. In addition, in February 2011, GAO reported that NNSA lacks complete data on, among other things, the condition and value of its existing infrastructure, cost estimates and completion dates for planned capital improvement projects, and critical human capital skills in its contractor workforce that are needed for its programs. As a result, NNSA does not have a sound basis for making decisions on how to most effectively manage its portfolio of projects and other programs and lacks information that could help justify future budget requests or target cost savings opportunities. NNSA recognizes that its ability to make informed decisions is hampered and is taking steps to …
Date: February 16, 2012
Creator: United States. Government Accountability Office.
Object Type: Text
System: The UNT Digital Library
NEAMS Update. Quarterly Report for October - December 2011. (open access)

NEAMS Update. Quarterly Report for October - December 2011.

The Advanced Modeling and Simulation Office within the DOE Office of Nuclear Energy (NE) has been charged with revolutionizing the design tools used to build nuclear power plants during the next 10 years. To accomplish this, the DOE has brought together the national laboratories, U.S. universities, and the nuclear energy industry to establish the Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program. The mission of NEAMS is to modernize computer modeling of nuclear energy systems and improve the fidelity and validity of modeling results using contemporary software environments and high-performance computers. NEAMS will create a set of engineering-level codes aimed at designing and analyzing the performance and safety of nuclear power plants and reactor fuels. The truly predictive nature of these codes will be achieved by modeling the governing phenomena at the spatial and temporal scales that dominate the behavior. These codes will be executed within a simulation environment that orchestrates code integration with respect to spatial meshing, computational resources, and execution to give the user a common 'look and feel' for setting up problems and displaying results. NEAMS is building upon a suite of existing simulation tools, including those developed by the federal Scientific Discovery through Advanced Computing and …
Date: February 16, 2012
Creator: Bradley, K. (Nuclear Engineering Division)
Object Type: Report
System: The UNT Digital Library
Pair Production Constraints on Superluminal Neutrinos Revisited (open access)

Pair Production Constraints on Superluminal Neutrinos Revisited

We revisit the pair creation constraint on superluminal neutrinos considered by Cohen and Glashow in order to clarify which types of superluminal models are constrained. We show that a model in which the superluminal neutrino is effectively light-like can evade the Cohen-Glashow constraint. In summary, any model for which the CG pair production process operates is excluded because such timelike neutrinos would not be detected by OPERA or other experiments. However, a superluminal neutrino which is effectively lightlike with fixed p{sup 2} can evade the Cohen-Glashow constraint because of energy-momentum conservation. The coincidence involved in explaining the SN1987A constraint certainly makes such a picture improbable - but it is still intrinsically possible. The lightlike model is appealing in that it does not violate Lorentz symmetry in particle interactions, although one would expect Hughes-Drever tests to turn up a violation eventually. Other evasions of the CG constraints are also possible; perhaps, e.g., the neutrino takes a 'short cut' through extra dimensions or suffers anomalous acceleration in matter. Irrespective of the OPERA result, Lorentz-violating interactions remain possible, and ongoing experimental investigation of such possibilities should continue.
Date: February 16, 2012
Creator: Brodsky, Stanley J. & Gardner, Susan
Object Type: Article
System: The UNT Digital Library
El Paso County Community College District Annual Financial Report: 2011 (open access)

El Paso County Community College District Annual Financial Report: 2011

Annual financial report of the El Paso County Community College District for fiscal year 2011 providing statements of assets, revenues, expenses, taxes, and other relevant data.
Date: February 16, 2012
Creator: El Paso County Community College District. Financial and Information Services.
Object Type: Report
System: The Portal to Texas History
Preparation of Radiopharmaceuticals Labeled with Metal Radionuclides (open access)

Preparation of Radiopharmaceuticals Labeled with Metal Radionuclides

The overall goal of this project was to develop methods for the production of metal-based radionuclides, to develop metal-based radiopharmaceuticals and in a limited number of cases, to translate these agents to the clinical situation. Initial work concentrated on the application of the radionuclides of Cu, Cu-60, Cu-61 and Cu-64, as well as application of Ga-68 radiopharmaceuticals. Initially Cu-64 was produced at the Missouri University Research Reactor and experiments carried out at Washington University. A limited number of studies were carried out utilizing Cu-62, a generator produced radionuclide produced by Mallinckrodt Inc. (now Covidien). In these studies, copper-62-labeled pyruvaldehyde Bis(N{sup 4}-methylthiosemicarbazonato)-copper(II) was studied as an agent for cerebral myocardial perfusion. A remote system for the production of this radiopharmaceutical was developed and a limited number of patient studies carried out with this agent. Various other copper radiopharmaceuticals were investigated, these included copper labeled blood imaging agents as well as Cu-64 labeled antibodies. Cu-64 labeled antibodies targeting colon cancer were translated to the human situation. Cu-64 was also used to label peptides (Cu-64 octriatide) and this is one of the first applications of a peptide radiolabeled with a positron emitting metal radionuclide. Investigations were then pursued on the preparation of the …
Date: February 16, 2012
Creator: Welch, M.J.
Object Type: Report
System: The UNT Digital Library