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Astatine-211 Radiochemistry: The Development of Methodologies for High Activity Level Radiosynthesis
Targeted radionuclide therapy is emerging as a viable approach for cancer treatment because of its potential for delivering curative doses of radiation to malignant cell populations while sparing normal tissues. Alpha particles such as those emitted by 211At are particularly attractive for this purpose because of their short path length in tissue and high energy, making them highly effective in killing cancer cells. The current impact of targeted radiotherapy in the clinical domain remains limited despite the fact that in many cases, potentially useful molecular targets and labeled compounds have already been identified. Unfortunately, putting these concepts into practice has been impeded by limitations in radiochemistry methodologies. A critical problem is that the synthesis of therapeutic radiopharmaceuticals provides additional challenges in comparison to diagnostic reagents because of the need to perform radio-synthesis at high levels of radioactivity. This is particularly important for {alpha}-particle emitters such as 211At because they deposit large amounts of energy in a highly focal manner. The overall objective of this project is to develop convenient and reproducible radiochemical methodologies for the radiohalogenation of molecules with the {alpha}-particle emitter 211At at the radioactivity levels needed for clinical studies. Our goal is to address two problems in astatine …
Date:
August 8, 2012
Creator:
Zalutsky, Michael R.
Object Type:
Report
System:
The UNT Digital Library
Keeping America’s Pipelines Safe and Secure: Key Issues for Congress
None
Date:
February 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Medicare’s Skilled Nursing Facility Primer: Benefit Basics and Issues
None
Date:
August 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Pesticide Registration and Tolerance Fees: An Overview
None
Date:
November 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Remote Gambling: Industry Trends and Federal Policy
None
Date:
November 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Social Security Administration (SSA): Budget Issues
None
Date:
March 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
Social Security: Cost-of-Living Adjustments
None
Date:
November 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The Social Security Number: Legal Developments Affecting Its Collection, Disclosure, and Confidentiality
None
Date:
February 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The Speech or Debate Clause: Constitutional Background and Recent Developments
None
Date:
August 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The Trend in Family Income from 1979 to 2010
None
Date:
February 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The U.S.-Panama Free Trade Agreement
None
Date:
November 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library
The United States as a Net Debtor Nation: Overview of the International Investment Position
None
Date:
November 8, 2012
Creator:
unknown
Object Type:
Report
System:
The UNT Digital Library