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Gene by Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction
Chronic cocaine use has been associated with structural deficits in brain regions having dopamine receptive neurons. However, the concomitant use of other drugs and common genetic variability in monoamine regulation present additional structural variability. We therefore examined variations in gray matter volume (GMV) as a function of lifetime drug use and the monoamine oxidase A (MAOA) genotype in cocaine use disorders (CUD) and healthy controls.
Date:
December 5, 2010
Creator:
Alia-Klein, N.; Alia-Klein, N.; Parvaz, M. A.; Woicik, P. A.; Konova, A.; Maloney, T. et al.
System:
The UNT Digital Library