The authors are developing a next-generation software environment to support large-scale DNA sequencing for the Human Genome Project. The goal is to automate the data flow from its generation by the DNA sequencing hardware to the final reconstructed sequence. Thus, the emphasis is on automation while providing efficient graphical interfaces for interaction with or inspection of the data. A secondary goal is to develop a system flexible enough to support a range of sequencing strategies, including random, and various directed and mixed strategies. The project will result in a software product named the {open_quotes}Genome Reconstruction Manager{close_quotes} (GRM). The authors are presently engaged in the final phase during which they plan to deliver a production quality system to a small number of DNA sequencing laboratories. By the end of the project they will have accomplished the main objectives stated in their original proposal except that GRM will not include all of the analytical capabilities that were planned. The reason for this is that the system proved to be much more complex than originally expected and required more effort to be devoted to system design and implementation. However, the design of GRM anticipates the addition of analytical capabilities and the strategy to …

This test plan describes the field demonstration of the sonic drilling system being conducted as a coordinated effort between the VOC-Arid ID (Integrated Demonstration) and the 200 West Area Carbon Tetrachloride ERA (Expedited Response Action) programs at Hanford. The purpose of this test is to evaluate the Water Development Corporation`s drilling system, modify components as necessary and determine compatible drilling applications for the sonic drilling method for use at facilities in the DOE complex. The sonic demonstration is being conducted as the first field test under the Cooperative Research and Development Agreement (CRADA) which involves the US Department of Energy, Pacific Northwest Laboratory, Westinghouse Hanford Company and Water Development Corporation. The sonic drilling system will be used to drill a 45 degree vadose zone well, two vertical wells at the VOC-Arid ID site, and several test holes at the Drilling Technology Test Site north of the 200 Area fire station. Testing at other locations will depend on the performance of the drilling method. Performance of this technology will be compared to the baseline drilling method (cable-tool).

A project to document the insect species in the upper reaches of Upper Three Runs at the Savannah River site was recently completed. This research was supported by the US Department of Energy under the National Environmental Research Park Program. The work was performed by the Department of Entomology at Clemson University in clemson, SC, by John C. Morse (principal investigator), William R. English and their colleagues. The major output from this study was the dissertation of Dr. William R. English entitled ``Ecosystem Dynamics of a South Carolina Sandhills Stream.`` He investigated selected environmental resources and determined their dynamics and the dynamics of the aquatic invertebrate community structure in response to them.

Knowledge of the production and destruction of long-lived species via neutrons, photons, and charged-particles is required in many fusion energy applications, such as reactor first-wall and blanket design, radioactive waste management, etc. Here we describe our calculational results for the production, via the (n,2n) reaction, of the following long-lived species: {sup 150}Eu(t{sub 1/2} = 36 y), {sup 152}Eu(t{sub 1/2} = 13 y), and {sup 192m2}Ir(t{sub 1/2} = 241 y). Some comments on calculations that we`ve made for destruction reactions of these species are also included.