This report provides a framework for examining the current status and future prospects for U.S.- Mexican security cooperation. It begins with a brief discussion of the threat that drug trafficking and related crime and violence pose to both nations, followed by an analysis of the evolution of the Mérida Initiative. The report then provides an overview of the Peña Nieto government's security strategy and how it is affecting the Mérida Initiative. The report then examines key aspects of the current U.S.-Mexican security strategy and concludes by raising policy issues that may affect bilateral efforts.