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Office of Scientific & Technical Information Technical Reports
284
Defense Base Closure and Realignment Commission
146
Congressional Research Service Reports
116
Texas Patents
53
Government Accountability Office Reports
39
Texas Attorney General Opinions
33
Technical Report Archive and Image Library
24
National Advisory Committee for Aeronautics Collection
14
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The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50
The BARD1 N-terminal RING domain binds BRCA1 while the BARD1 C-terminal ankyrin and tandem BRCT repeat domains bind CstF-50 to modulate mRNA processing and RNAP II stability in response to DNA damage. Here we characterize the BARD1 structural biochemistry responsible for CstF- 50 binding. The crystal structure of the BARD1 BRCT domain uncovers a degenerate phosphopeptide binding pocket lacking the key arginine required for phosphopeptide interactions in other BRCT proteins.Small angle X-ray scattering together with limited proteolysis results indicates that ankyrin and BRCT domains are linked by a flexible tether and do not adopt a fixed orientation relative to one another. Protein pull-down experiments utilizing a series of purified BARD1 deletion mutants indicate that interactions between the CstF-50 WD-40 domain and BARD1 involve the ankyrin-BRCT linker but do not require ankyrin or BRCT domains. The structural plasticity imparted by the ANK-BRCT linker helps to explain the regulated assembly of different protein BARD1 complexes with distinct functions in DNA damage signaling including BARD1-dependent induction of apoptosis plus p53 stabilization and interactions. BARD1 architecture and plasticity imparted by the ANK-BRCT linker are suitable to allow the BARD1 C-terminus to act as a hub with multiple binding sites to integrate diverse DNA damage …
Date:
July 13, 2009
Creator:
Edwards, Ross A.; Lee, Megan S.; Tsutakawa, Susan E.; Williams, R. Scott; Tainer, John A. & Glover, J. N. Mark
Object Type:
Article
System:
The UNT Digital Library
Barrel Truck.
Patent for a new and improved barrel cart. This design "is to provide an improved barrel rack or truck which can be conveniently and easily loaded and transported from place to place; to provide means for assisting in loading the barrel or receptacle on the truck and for retaining the same on the truck against danger of accidental displacement while the truck and its contents are being moved or transported, and to provide an improved truck which shall be very simple, strong, and durable in construction, thoroughly effective in operation, and cheap and inexpensive of manufacture" (lines 14-26).
Date:
July 13, 1886
Creator:
Williams, William Preston
Object Type:
Patent
System:
The Portal to Texas History
Base Input - 43rd Airlift Wing Pope AFB, NC
BRAC Commission Brief to Commissioner Gehman (Fort Bragg) and presentation of Pope AFB
Date:
July 13, 2005
Creator:
unknown
Object Type:
Text
System:
The UNT Digital Library
Base visit book for Fort Bliss, Texas to the BRAC Commission
Base Visit- Base visit book for Fort Bliss, Texas to the BRAC Commission. Includes questions and concerns, and any other general information.
Date:
July 13, 2005
Creator:
United States. Defense Base Closure and Realignment Commission.
Object Type:
Book
System:
The UNT Digital Library
Base Visit Book - Naval Medical Center, San Diego and Naval Air Depot, North Island, Coronado, CA PART 1
Base Visit Book - Naval Medical Center, San Diego and naval Air Depot, North island, Coronado, CA PART 1
Date:
July 13, 2005
Creator:
unknown
Object Type:
Book
System:
The UNT Digital Library
Base Visit Book - Naval Medical Center, San Diego and Naval Air Depot, North Island, Coronado, CA - Part 2
Base Visit Book - Naval Medical Center, San Diego and Naval Air Depot, North Island, Coronado, CA - PART 2
Date:
July 13, 2005
Creator:
United States. Defense Base Closure and Realignment Commission.
Object Type:
Book
System:
The UNT Digital Library
BED-BOTTOM
Patent for "a new and useful improvement in bed bottoms". The bed bottom fits any bedstead and it is cheap, portable, and durable.
Date:
July 13, 1880
Creator:
Pafford, John R.
Object Type:
Patent
System:
The Portal to Texas History
Behavior of Dense, Immiscible Solvents in Fractured Clay-rich Soils
This research program addresses the nature and distribution of chlorinated solvent DNAPL sources in fractured clays and weathered shales, and the potential for natural attenuation of plumes derived from these sources. Specific objectives include: (1) Investigate the factors controlling migration of chlorinated solvent DNAPLs in fine-grained, highly structured soils and weathered shale bedrock. (2) Investigate the influence of ''matrix diffusion'' on the dissolution and apparent disappearance of residual DNAPL. (3) Investigate potential for biodegradation of chlorinated solvents in fractured and weathered shales at an existing contaminated field site and through the use of laboratory studies in microcosms and undisturbed columns of fractured shale saprolite. (4) Comparison of DNAPL behavior in different types of fractured clay-rich materials.
Date:
July 13, 2000
Creator:
McKay, Larry D.; Sanseverino, John; Jardine, Phillip M.; Brooks, Scott C.; Cherry, John A. & Parker, Beth L.
Object Type:
Report
System:
The UNT Digital Library
Bench-Scale Evaporation of a Large Hanford Envelope C Sample (Tank 241-AN-102)
This report contains the results of the Bench Scale evaporation of a large sample of pretreated Envelope C (AN102).
Date:
July 13, 2001
Creator:
Crowder, M.L.
Object Type:
Report
System:
The UNT Digital Library
Bibliography on CO{sub 2} Effects on Vegetation and Ecosystems: 1990-1999 Literature
None
Date:
July 13, 2000
Creator:
Jones, M.H.
Object Type:
Report
System:
The UNT Digital Library
Bicycle Alarm
Patent for a "simple and cheap as well as ornamental bicycle-whistle...of novel and peculiar construction, adapted for attachment to the bicycle and made to sound at pleasure" (lines 14-18). Illustrations and instructions are included.
Date:
July 13, 1897
Creator:
Crump, William E.
Object Type:
Patent
System:
The Portal to Texas History
Binder of Letters received by concerned constituents supporting the 130th Airlift Wing
Binder of 508 letters received by concerned constituents supporting the 130th Airlift Wing
Date:
July 13, 2005
Creator:
unknown
Object Type:
Letter
System:
The UNT Digital Library
Biofuels News, Spring/Summer 2001, Vol. 4, No. 2
Newsletter for the DOE biofuels program. This issue contains articles on the National Energy Policy Plan, national energy policy, the proposed budget for biofuels, and new faces at DOE.
Date:
July 13, 2001
Creator:
Tuttle, J.
Object Type:
Book
System:
The UNT Digital Library
Biomimetic Actinide Chelators: An Update on the Preclinical Development of the Orally Active Hydroxypyridonate Decorporation Agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO)
The threat of a dirty bomb or other major radiological contamination presents a danger of large-scale radiation exposure of the population. Because major components of such contamination are likely to be actinides, actinide decorporation treatments that will reduce radiation exposure must be a priority. Current therapies for the treatment of radionuclide contamination are limited and extensive efforts must be dedicated to the development of therapeutic, orally bioavailable, actinide chelators for emergency medical use. Using a biomimetic approach based on the similar biochemical properties of plutonium(IV) and iron(III), siderophore-inspired multidentate hydroxypyridonate ligands have been designed and are unrivaled in terms of actinide-affinity, selectivity, and efficiency. A perspective on the preclinical development of two hydroxypyridonate actinide decorporation agents, 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO), is presented. The chemical syntheses of both candidate compounds have been optimized for scale-up. Baseline preparation and analytical methods suitable for manufacturing large amounts have been established. Both ligands show much higher actinide-removal efficacy than the currently approved agent, diethylenetriaminepentaacetic acid (DTPA), with different selectivity for the tested isotopes of plutonium, americium, uranium and neptunium. No toxicity is observed in cells derived from three different human tissue sources treated in vitro up to ligand concentrations of 1 mM, and both ligands …
Date:
July 13, 2011
Creator:
Durbin, Patricia W.; Kullgren, Birgitta; Ebbe, Shirley N.; Xu, Jide; Chang, Polly Y.; Bunin, Deborah I. et al.
Object Type:
Article
System:
The UNT Digital Library
Biosynthesis of the cyclotide Kalata B1 using protein splicing tools
Cyclotides are a new emerging family of large cyclic polypeptides ({approx}30 residues long) that share a disulfide-stabilized core (3 disulfide bonds) with an unusual knotted structure (Fig. 1A) [1]. Cyclotides contrast with other circular polypeptides in that they have a highly defined three-dimensional structure, and despite their small size, can be considered as miniproteins. Their unique circular backbone topology and knotted arrangement of 3 disulfide bonds makes them exceptionally stable to thermal and enzymatic degradation. Furthermore, their well defined structures have been also associated with a range of biological activities, including uterotonic activity, inhibition of neurotension binding, hemolytic, anti-HIV, insecticidal as well as trypsin inhibitory activity. Altogether, these characteristics make cyclotides ideal candidates to be used as molecular scaffolds for the development of stable peptide drugs [2]. Access to biosynthetic cyclotides using recombinant DNA expression techniques would offer the exciting possibility of producing large combinatorial libraries of highly stable miniproteins using the tools of molecular biology. This would allow the generation of cell-based combinatorial libraries that could be screened inside living cells for their ability to regulate cellular processes. In the present work we describe for the first time the biosynthesis of the cyclotide Kalata B1 in E. coli. Our …
Date:
July 13, 2005
Creator:
Kimura, R.; Krishnan, K. & Camarero, J. A.
Object Type:
Article
System:
The UNT Digital Library
Blanket design for the mirror fusion/fission hybrid reactor
The evolution of this particular blanket concept is described. The geometry of the mirror reactor blanket and the replacement methods that are employed are described. The sub-module design and its thermal-hydraulic considerations, the nuclear model geometry and compositions, and the nuclear calculational method are described. A brief reference is made to calculational vs. experimental results.
Date:
July 13, 1976
Creator:
Lee, J. D.
Object Type:
Article
System:
The UNT Digital Library
Boiler-Tube
Patent for an improved boiler tube which is more durable and easier to install and remove than other boiler tubes.
Date:
July 13, 1915
Creator:
Burkett, Frank
Object Type:
Patent
System:
The Portal to Texas History
Borated Materials and Components for Nuclear Shielding and Waste Contamination Applications. Final Crada Report.
None
Date:
July 13, 2010
Creator:
Ehst, D. & Division, Nuclear Engineering
Object Type:
Report
System:
The UNT Digital Library
Border Security: Additional Actions Needed to Eliminate Weaknesses in the Visa Revocation Process
A letter report issued by the Government Accountability Office with an abstract that begins "The National Strategy for Homeland Security calls for preventing foreign terrorists from entering our country and using all legal means to identify; halt; and where appropriate, prosecute or bring immigration or other civil charges against terrorists in the United States. GAO reported in June 2003 that the visa revocation process needed to be strengthened as an antiterrorism tool and recommended that the Department of Homeland Security (DHS), in conjunction with the Departments of State (State) and Justice, develop specific policies and procedures to ensure that appropriate agencies are notified of revocations based on terrorism grounds and take proper actions. GAO examined whether weaknesses in the visa revocation process identified in its June 2003 report were addressed."
Date:
July 13, 2004
Creator:
United States. Government Accountability Office.
Object Type:
Report
System:
The UNT Digital Library
Border Security: Additional Actions Needed to Eliminate Weaknesses in the Visa Revocation Process
Testimony issued by the Government Accountability Office with an abstract that begins "The National Strategy for Homeland Security calls for preventing foreign terrorists from entering our country and using all legal means to identify; halt; and where appropriate, prosecute or bring immigration or other civil charges against terrorists in the United States. GAO reported in June 2003 that the visa revocation process needed to be strengthened as an antiterrorism tool and recommended that the Department of Homeland Security (DHS), in conjunction with the Departments of State (State) and Justice, develop specific policies and procedures to ensure that appropriate agencies are notified of revocations based on terrorism grounds and take proper actions. GAO examined whether weaknesses in the visa revocation process identified in our June 2003 report were addressed."
Date:
July 13, 2004
Creator:
United States. Government Accountability Office.
Object Type:
Text
System:
The UNT Digital Library
Border Security: Long-term Strategy Needed to Keep Pace with Increasing Demand for Visas
A letter report issued by the Government Accountability Office with an abstract that begins "After the 9/11 terrorist attacks, Congress and the Department of State (State) initiated changes to the visa process to increase security, but these changes also increased the amount of time needed to adjudicate a visa. Although maintaining security is of paramount importance, State has acknowledged that long waits for visas may discourage legitimate travel to the United States, potentially costing the country billions of dollars in economic benefits over time, and adversely influencing foreign citizens' opinions of our nation. GAO testified in 2006 that a number of consular posts had long visa interview wait times. This report examines (1) State's data on visa interview wait times, (2) actions State has taken to address wait times, and (3) State's strategy for dealing with projected growth in visa demand."
Date:
July 13, 2007
Creator:
United States. Government Accountability Office.
Object Type:
Report
System:
The UNT Digital Library
Bounding Peak Ground Velocities for Seismic Events at Yucca Mountain, Nevada
Earthquake ground motions have been assessed using a probabilistic seismic hazard analysis (PSHA) of the proposed repository for spent nuclear fuel and high-level radioactive wastes at Yucca Mountain, Nevada. To meet the applicable regulations, consideration must be given to ground motions that have probabilities of exceedance as low as 10{sup -8}/yr. In the PSHA, aleatory variability in ground motion attenuation relations is characterized by unbounded lognormal distributions. At extremely low annual probability levels, the tails of these distributions, along with large assessed epistemic uncertainties in ground motions from large, close earthquakes, result in upper-percentile and mean ground motions that are extremely high and probably unphysical. To address this issue, we evaluated site-specific geologic evidence with respect to an upper bound on peak ground velocity (PGV), the ground motion measure that is correlated with damage to underground repository systems. Ground-motion amplitudes are limited by the strength of the materials through which they propagate. At high enough levels of seismic shaking, the rocks at the waste-emplacement level, particularly the lithophysal tuffs, will fracture and fail. A key finding of geologic relations from underground explorations and rock-mechanics modeling is the absence of mechanical damage of the type expected from seismic shaking in the …
Date:
July 13, 2004
Creator:
King, J.; Coppersmith, K. & Quittmeyer, R.
Object Type:
Report
System:
The UNT Digital Library
BRAC Early Bird 13 July 2005
Collection of BRAC related news articles and clippings. Produced for Commission staff review.
Date:
July 13, 2005
Creator:
United States. Defense Base Closure and Realignment Commission.
Object Type:
Text
System:
The UNT Digital Library
Brake.
Patent for a new brake design that forms part of the driving mechanism of a sewing machine. The design has been adapted to include a plurality of small rollers that exert different amounts of friction on brake wheels.
Date:
July 13, 1913
Creator:
Gaines, John
Object Type:
Patent
System:
The Portal to Texas History