General considerations involving the transportation of irradiated fuel and radioactive wastes are reviewed. It is assumed that many reactors will supply feed to a few large multipurpose chemical plants which ultimately send radioactive waste to a few disposal sites. General economic considerations of irradiated fuel reprocessing, economic aspects of the nuclear economy complex, growth predictions of the nuclear power economy in the U.S., general requirements for the shipment of fuel and waste, regulations applicable to fuel shipment, and permissible radiation levels are discussed.