Extracellular matrix and extracellular matrix-degrading matrix metalloproteinases play a key role in interactions between the epithelium and the mesenchyme during mammary gland development and disease. In patients with breast cancer, the mammary mesenchyme undergoes a stromal reaction, the etiology of which is unknown. We previously showed that targeting of an autoactivating mutant of the matrix metalloproteinase stromelysin-1 to mammary epithelia of transgenic mice resulted in reduced mammary function during pregnancy and development of preneoplastic and neoplastic lesions. Here we examine the cascade of alterations before breast tumor formation in the mammary gland stroma once the expression of the stromelysin-1 transgene commences. Beginning in postpubertal virgin animals, low levels of transgene expression in mammary epithelia led to increased expression of endogenous stromelysin-1 in stromal fibroblasts and up-regulation of other matrix metalloproteinases, without basement membrane disruption. These changes were accompanied by the progressive development of a compensatory reactive stroma, characterized by increased collagen content and vascularization in glands from virgin mice. This remodeling of the gland affected epithelial-mesenchymal communication as indicated by inappropriate expression of tenascin-C starting by day 6 of pregnancy. This, together with increased transgene expression, led to basement membrane disruption starting by day 15 of pregnancy. We propose that …

A weekly publication, the Texas Register serves as the journal of state agency rulemaking for Texas. Information published in the Texas Register includes proposed, adopted, withdrawn and emergency rule actions, notices of state agency review of agency rules, governor's appointments, attorney general opinions, and miscellaneous documents such as requests for proposals. After adoption, these rulemaking actions are codified into the Texas Administrative Code.

The Materials Microcharacterization Collaborator (MMC) was created last year as a pilot project within the US Department of Energy's DOE2000 program [1]. The DOE2000 program has, as its main goals, to develop improved capabilities for solving DOE's complex scientific problems, to increase DOE's R and D productivity and efficiency, and to enhance the access of R and D partners to DOE resources. One of the strategies to meet these goals is the establishment of national collaboratories to provide access via the Internet to unique or expensive DOE research facilities and to expertise for remote collaboration, experimentation, production, software development, modeling, and measurement. In addition, collaboratories will benefit researchers by providing tools for video conferencing, shared data-viewing, and collaborative analysis. Cooperative pilots projects, jointly funded by DOE2000 and a scientific program area, are expected to lead to significant scientific achievements by developing new capabilities and increasing the efficiency of doing the work (e.g., by reducing travel, increasing communication, and promoting the sharing of data among formerly disparate research groups). The MMC project unites four DOE BES electron microscopy user centers located at ANL, LBNL, ORNL and the University of Illinois with the DOE EE center located at ORNL. Also included in …

The manufacturing of steel containment vessels starts with the forming of flat plates into curved plates. A steel containment structure is made by welding individual plates together to form the sections that make up the complex shaped vessels. The metal forming and welding process leaves residual stresses in the vessel walls. Generally, the effect of metal forming residual stresses can be reduced or virtually eliminated by thermally stress relieving the vessel. In large containment vessels this may not be practical and thus, the residual stresses due to manufacturing may become important. The residual stresses could possibly affect the response of the vessel to internal pressurization. When the level of residual stresses is significant it will affect the vessel's response, for instance the yielding pressure and possibly the failure pressure. This paper will address the effect of metal forming residual stresses on the response of a generic pressure vessel to internal pressurization. A scoping analysis investigated the effect of residual forming stresses on the response of an internally pressurized vessel. A simple model was developed to gain understanding of the mechanics of the problem. Residual stresses due to the welding process were not considered in this investigation.

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This report discusses the federal sugar program, which authorized by the Federal Agriculture Improvement and Reform Act of 1996 seeks to ensure the viability of the U.S. sugar producing sector primarily by supporting the incomes of sugar beet and sugarcane producers and of those firms that process each crop into sugar.

This service is run by Group T-2 (Nuclear Theory and Applications) of the Theoretical Division of the Los Alamos National Laboratory, which is operated by the University of California for the US Department of Energy. The author works on nuclear modeling, nuclear data, cross sections, nuclear masses, ENDF, NJOY data processing, nuclear astrophysics, radioactivity, radiation shielding, data for medical radiotherapy, data for high-energy accelerator applications, data and codes for fission and fusion systems, and more. For an introduction to the field of nuclear data and his site, take his Guided Tour. Much of this information can also be accessed using anonymous ftp t2.lanl.gov.

A technique currently under study for the detection of ultrahigh energy cosmic ray neutrinos involves the measurement of radio emissions from the electromagnetic shower generated by the neutrino in a large volume of naturally occurring dielectric such as the Antarctic ice cap or salt domes. The formation of an electron excess in the shower leads to the emission of coherent Cherenkov radiation, an effect similar to the generation of wakefields in dielectric loaded structures. We have used the finite difference time domain (FDTD) wakefield code ARRAKIS to model coherent Cherenkov radiation fields from high energy showers; we present as an example calculations of expected signals in a proof of principle experiment proposed for the Fermilab Main Injector.

The Department of Energy has selected immobilization for disposal in a repository as one approach for disposing of excess plutonium (1). Materials for immobilizing weapons-grade plutonium for repository disposal must meet the ''spent fuel standard'' by providing a radiation field similar to spent fuel (2). Such a radiation field can be provided by incorporating fission products from high-level waste into the waste form. Experiments were performed to evaluate the feasibility of incorporating high-level waste (HLW) stored at the Idaho Chemical Processing Plant (ICPP) into plutonium dispositioning materials to meet the spent fuel standard. A variety of materials and preparation techniques were evaluated based on prior experience developing waste forms for immobilizing HLW. These included crystalline ceramic compositions prepared by conventional sintering and hot isostatic pressing (HIP), and glass formulations prepared by conventional melting. Because plutonium solubility in silicate melts is limited, glass formulations were intentionally devitrified to partition plutonium into crystalline host phases, thereby allowing increased overall plutonium loading. Samarium, added as a representative rare earth neutron absorber, also tended to partition into the plutonium host phases. Because the crystalline plutonium host phases are chemically more inert, the plutonium is more effectively isolated from the environment, and its attractiveness for …

This paper will describe the preparation and progress of the effort at Argonne National Laboratory-West to produce ceramic waste forms loaded with {sup 238}Pu. The purpose of this study is to determine the extent of damage, if any, that alpha decay events will play over time to the ceramic waste form under development at Argonne. The ceramic waste form is glass-bonded sodalite. The sodalite is utilized to encapsulate the fission products and transuranics which are present in a chloride salt matrix which results from a spent fuel conditioning process. {sup 238}Pu possesses approximately 250 times the specific activity of {sup 239}Pu and thus allows for a much shorter time frame to address the issue. In preparation for production of {sup 238}Pu loaded waste forms {sup 239}Pu loaded samples were produced. Data is presented for samples produced with typical reactor grade plutonium. X-ray diffraction, scanning electron micrographs and durability test results will be presented. The ramifications for the production of the {sup 238}Pu loaded samples will be discussed.

An integral function of the electrometallurgical conditioning of DOE spent nuclear fuel is the standardization of waste forms. Argonne National Laboratory (ANL) has developed and is presently demonstrating the electrometallurgical conditioning of sodium-bonded metal fuel from Experimental Breeder Reactor II, resulting in uranium, ceramic waste, and metal waste forms. Engineering studies are underway at ANL in support of pilot-scale equipment development, which would precondition irradiated oxide fuel and likewise demonstrate the application of electrometallurgical conditioning to such non-metallic fuels. This paper highlights the integration of proposed spent oxide fuel conditioning with existing electrometallurgical processes. Additionally, technical bases for engineering activities to support a scale up of an oxide reduction process are described.

The conference report on H.R. 1757, the Foreign Relations Authorization bill for FY1998-FY1999, will be debated in the Senate beginning April 24 with a vote expected April 28, 1998. On March 26, the House adopted the conference report (H.Rept. 105-432) on H.R. 1757; the bill authorizes a total of $926 million for payment of arrears to international organizations in exchange for U.N. and U.N. agency reforms. The House version of the bill did not address payment of the U.S. arrears or U.N. reforms. The conferees accepted virtually all the Senate language in Conference. The Conference version of the bill also contains unrelated House language restricting activities of foreign family planning organizations, which the President has threatened to veto. This linkage derailed passage of the bill in 1997.