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01-ERD-111 - The Development of Synthetic High Affinity Ligands
The aim of this project was to develop Synthetic High-Affinity Ligands (SHALs), which bind with high affinity and specificity to proteins of interest for national security and cancer therapy applications. The aim of producing synthetic ligands for sensory devices as an alternative to antibody-based detection assays and therapeutic agents is to overcome the drawbacks associated with antibody-based in next-generation sensors and systems. The focus area of the project was the chemical synthesis of the SHALs. The project concentrated on two different protein targets. (a) The C fragment of tetanus and botulinum toxin, potential biowarfare agents. A SHAL for tetanus or botulinum toxin would be incorporated into a sensory device for the toxins. (b) HLA-DR10, a protein found in high abundance on the surface of Non-Hodgkins Lymphoma. A SHAL specific to a tumor marker, labeled with a radionuclide, would enable the targeted delivery of radiation therapy to metastatic disease. The technical approach used to develop a SHAL for each protein target will be described in more detail below. However, in general, the development of a SHAL requires a combination of computational modeling techniques, modern nuclear magnetic resonance spectroscopy (NMR) and synthetic chemistry.
Date:
February 5, 2004
Creator:
Perkins, J; Balhorn, R; Cosman, M; Lightstone, F & Zeller, L
Object Type:
Report
System:
The UNT Digital Library
60-day waste compatibility safety issues and final results for TX-244 grab samples
Three grab samples (244-TX-96-1, 244-TX-96-2, and 244-TX-96-3) were taken from Riser 8 of Tank 241-TX-244 on October 18, 1996, and received by 222-S Laboratory on October 18, 1996. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) in support ofthe Waste Compatibility Program. Notifications were made in accordance with TSAP for pH and OH- analyses. Upon further review, the pH notification was deemed unnecessary, as the notification limit did not apply to this tank.
Date:
February 5, 1997
Creator:
Nuzum, J. L.
Object Type:
Report
System:
The UNT Digital Library
The 2018 National Defense Strategy
This report discusses the 2018 National Defense Strategy which lays out the goals and methods of the Defense Department for the year.
Date:
February 5, 2018
Creator:
McInnis, Kathleen J.
Object Type:
Report
System:
The UNT Digital Library
21st Century Community Learning Centers: Background and Funding
This report summarizes the reauthorized Elementary and Secondary Education Act (ESEA) which contains the 21st Century Community Learning Centers (21st CCLC) program. The report covers the history of the ESEA as well as what is new in the reauthorization. Moreover, the report includes how grants are selected now, and the new focus of the program which is now exclusively for after-school-hours activities for children.
Date:
February 5, 2008
Creator:
McCallion, Gail
Object Type:
Report
System:
The UNT Digital Library
78th Texas Legislature, Regular Session, House Concurrent Resolution 26
Concurrent resolution introduced by the Texas House of Representatives and Senate relating to honoring soldiers from Fort Hood who are being deployed for Operation Enduring Freedom.
Date:
February 5, 2003
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
78th Texas Legislature, Regular Session, Senate Concurrent Resolution 4
Concurrent resolution introduced by the Texas Senate and House of Representatives relating to January 13 through January 26, 2003, as the Texas Centennial of Flight Celebration.
Date:
February 5, 2003
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
84th Texas Legislature, Regular Session, House Concurrent Resolution 44
Concurrent resolution introduced by the Texas House of Representatives and Senate in memory of U.S. Army Sergeant Gilberto Lopez Sanchez of New Braunfels.
Date:
February 5, 2015
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
84th Texas Legislature, Regular Session, House Concurrent Resolution 45
Concurrent resolution introduced by the Texas House of Representatives and Senate granting the legislature permission to adjourn for more than three days.
Date:
February 5, 2015
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
84th Texas Legislature, Regular Session, House Concurrent Resolution 48
Concurrent resolution introduced by the Texas House of Representatives and Senate inviting the governor to address a joint session of the legislature on February 17, 2015.
Date:
February 5, 2015
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
84th Texas Legislature, Regular Session, Senate Concurrent Resolution 3
Concurrent resolution introduced by the Texas House of Representatives and Senate providing for procedures for the canvass of votes for the governor and lieutenant governor and the inauguration of the governor and lieutenant governor, and inviting the governor to address a joint session of the legislature on January 15, 2015.
Date:
February 5, 2015
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
84th Texas Legislature, Regular Session, Senate Concurrent Resolution 4
Concurrent resolution introduced by the Texas House of Representatives and Senate granting the legislature permission to adjourn for more than three days during the period beginning on Thursday, January 15, 2015, and ending on Tuesday, January 20, 2015.
Date:
February 5, 2015
Creator:
Texas. Legislature. Senate.
Object Type:
Legislative Document
System:
The Portal to Texas History
86th Texas Legislature, Regular Session, House Concurrent Resolution 38
Concurrent resolution introduced by the Texas House of Representatives and Senate inviting the governor to address a joint session of the legislature on February 5, 2019.
Date:
February 5, 2019
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
86th Texas Legislature, Regular Session, House Concurrent Resolution 39
Concurrent resolution introduced by the Texas House of Representatives and Senate inviting the chief justice of the Supreme Court of Texas to address a joint session of the legislature on February 6, 2019.
Date:
February 5, 2019
Creator:
Texas. Legislature. House of Representatives.
Object Type:
Legislative Document
System:
The Portal to Texas History
Abortion: Judicial and Legislative Control
This report is about Abortions and Constitution Amendments.
Date:
February 5, 1974
Creator:
Lewis, Karen J. & Rosenberg, Morton
Object Type:
Report
System:
The UNT Digital Library
Abortion: Judicial and Legislative Control
This report
Date:
February 5, 1974
Creator:
Lewis, Karen J.
Object Type:
Report
System:
The UNT Digital Library
Abstract - INMM Annual Meeting 1998 Status of Underground Testing Program
This report is about the INMM Annual Meeting 1998 Status of Underground Testing Program.
Date:
February 5, 2008
Creator:
Dr. William J. Boyle, Larry R. Hayes, Alan J. Mitchell
Object Type:
Article
System:
The UNT Digital Library
Accelerator/Experiment Operations - FY 2001 Through FY 2003
This Technical Memorandum (TM) summarizes the accelerator and experiment operations for the period FY 2001 through FY 2003. The plan is to have an annual TM to gather such information in one place. In this case, the information concerns the startup of Run II at the Tevatron Collider and the beginning of the MiniBooNE neutrino experiment. While the focus is on the FY 2003 efforts, this document includes summaries of the earlier years where available for completeness.
Date:
February 5, 2004
Creator:
al., Jeffrey A. Appel et
Object Type:
Report
System:
The UNT Digital Library
Access to Broadband Networks: The Net Neutrality Debate
This report discusses the current debate over "net neutrality." While there is no single accepted definition of "net neutrality," most agree that any such definition should include the general principles that owners of the networks that compose and provide access to the Internet should not control how consumers lawfully use that network, and they should not be able to discriminate against content provider access to that network.
Date:
February 5, 2015
Creator:
Gilroy, Angele A.
Object Type:
Report
System:
The UNT Digital Library
Accomplishments Achieved Under DOE Grant Number DE-FG03-92ER40693: The Physics of Gain Mechanisms in Self-Amplified Spontaneous Emission in Free Electron Lasers
None
Date:
February 5, 2007
Creator:
Rosenzweig, James
Object Type:
Report
System:
The UNT Digital Library
Acute Histopathological Effects of Single Doses of Slow Neutrons on Mice
The following report provides information conducted during histological observations made on the anatomy of female mice who have been exposed to 400 arbitrary units of slow neutrons.
Date:
February 5, 1947
Creator:
Snider, R.
Object Type:
Report
System:
The UNT Digital Library
Adapting high-resolution speckle imaging to moving targets and platforms
High-resolution surveillance imaging with apertures greater than a few inches over horizontal or slant paths at optical or infrared wavelengths will typically be limited by atmospheric aberrations. With static targets and static platforms, we have previously demonstrated near-diffraction limited imaging of various targets including personnel and vehicles over horizontal and slant paths ranging from less than a kilometer to many tens of kilometers using adaptations to bispectral speckle imaging techniques. Nominally, these image processing methods require the target to be static with respect to its background during the data acquisition since multiple frames are required. To obtain a sufficient number of frames and also to allow the atmosphere to decorrelate between frames, data acquisition times on the order of one second are needed. Modifications to the original imaging algorithm will be needed to deal with situations where there is relative target to background motion. In this paper, we present an extension of these imaging techniques to accommodate mobile platforms and moving targets.
Date:
February 5, 2004
Creator:
Carrano, C J & Brase, J M
Object Type:
Article
System:
The UNT Digital Library
Advanced Large Area Plastic Scintillator Project (ALPS): Final Report
The advanced Large-Area Plastic Scintillator (ALPS) Project at Pacific Northwest National Laboratory investigated possible technological avenues for substantially advancing the state-of-the-art in gamma-ray detection via large-area plastic scintillators. The three predominant themes of these investigations comprised the following: * Maximizing light collection efficiency from a single large-area sheet of plastic scintillator, and optimizing hardware event trigger definition to retain detection efficiency while exploiting the power of coincidence to suppress single-PMT "dark current" background; * Utilizing anti-Compton vetoing and supplementary spectral information from a co-located secondary, or "Back" detector, to both (1) minimize Compton background in the low-energy portion of the "Front" scintillator's pulse-height spectrum, and (2) sharpen the statistical accuracy of the front detector's low-energy response prediction as impelmented in suitable energy-windowing algorithms; and * Investigating alternative materials to enhance the intrinsic gamma-ray detection efficiency of plastic-based sensors.
Date:
February 5, 2008
Creator:
Jordan, David V.; Reeder, Paul L.; Todd, Lindsay C.; Warren, Glen A.; McCormick, Kathleen R.; Stephens, Daniel L. et al.
Object Type:
Report
System:
The UNT Digital Library
Afghanistan: Government Formation and Performance
This report discusses the current political state of Afghanistan, as well as the Afghan government. This report also discusses Afghanistan's relationship with the United States, particularly U.S. efforts to urge President Hamid Karzai to address corruption within the Afghan government.
Date:
February 5, 2009
Creator:
Katzman, Kenneth
Object Type:
Report
System:
The UNT Digital Library
Agricultural Conservation: A Guide to Programs
This report provides a listing of federal agricultural conservation assistance programs. Each listing includes a brief description of the program, information on major amendments in the Agricultural Act of 2014 (P.L. 113-79, 2014 farm bill), national scope and availability, states with the greatest participation, the backlog of applications or other measures of continuing interest, program funding authority, FY2018 funding, FY2019 Administration budget request, statutory authority, the authorization expiration date, and a link to the program's website.
Date:
February 5, 2013
Creator:
Stubbs, Megan
Object Type:
Report
System:
The UNT Digital Library