This report reviews aspects of experimental and clinical research performed in the investigation on the pathogenesis and recovery of bone marrow injury caused by total body irradiation.

The object of this study was to determine the nature of the free radicals induced in ferrocene by Co60 gamma rays. The irradiations were carried out on the powder at 77°K and on the single crystals at 193°K. The variation of the splitting factor, g, of the signals observed when the single crystals were oriented at different angles relative to the external magnetic field direction, indicated the existence of three types of resonance peaks. It was possible to correlate these variations with the molecular orientations in the crystal unit cell and with the spatial arrangement of the molecular orbitals. Taking into account the spectral changes observed after thermal annealing of the crystal, the existence of the following free radicals has been suggested: 1) a straight molecule-ferricinium ion, 2) a bent molecule-ferricinium ion, and 3) a cyclopentadienyl radical with four protons, the fifth having been transferred to the iron atom. A signal with a cylindrically symmetric g tensor, observed at 77°K, has been assigned to another radical but its nature was not fully established.

Despite similar atomic arrangement, Brucite (Mg(OH)2) and phlogopite (KMg3(OH)2(Al,Si3)O10) present striking difference in their infrared spectra. A single absorption band is observed in phlogopite whence brucite possesses a total of 15 bands on both sides of the fundamental. A comparison of the hydroxides with micas provides supporting evidence that the complexity of the hydroxide spectra is due to interactions between neighboring hydroxyl groups. Each mineral contains a layer of magnesium ions possessing trigonal symmetry. Both minerals contain hydroxyl ion is located in such a way that it is in contract with three magnesium ions.

During a visit to Professor H.G. Harb at the University of Wisconsin, it was apparent that he had succeeded in obtaining fresh, clean chemisorptive layers of titanium by sublimation and chat that this could be adapted into an effective high vacuum pump. Two previous techniques of obtaining a chemisorptive layer of titanium, namely catholic sputtering and evaporation from the liquid droplet, have been extensively investigated and reported. Each of these seem to have inherent difficulties in stability and continuity of operation that appear to be eliminated or effectively reduced by the sublimation procedure. A development program was started at Brookhaven National Laboratory to investigate the possibilities of each sublimation of titanium as opposed to evaporation from the liquid.

The purpose if this paper is to present tables of perturbed wave functions which have been obtained in three recent investigations: (1) wave functions v1'(nℓ→ℓ') which pertains to the perturbation of the d electrons of various ions as a result of the potential due to a nuclear quadrupole moment Q3 (2) wave functions v1',H(nℓ→ℓ) which represent the antishielding of the d electrons for a possible nuclear hexadecapole moment H; (3) wave functions u2'(ns→p) which pertain to the dipole perturbation of the valence (ns) electrons of the alkali atoms. Throughout this paper, the notation is the same as in a previous report in which a similar tabulation of perturbed wave function was made.

Several important metabolic processes in plants involve the conversion of triose phosphate to hexose monophosphate. These include the synthesis of carbohydrates from precursors such as pyruvate and acetyl-coenzyme A, the reductive pentose phosphate cycle of photosynthesis, and the oxidative pentose phosphate cycle. This conversion cannot be accomplished solely by glycolytic enzymes because of the irreversible nature of phosphofructokinase. Racker and Schroeder (1958) have suggested two possible enzymic pathways for the formation of fructose 6-phosphate from triose phosphate. The most direct route is via a phosphate specific for the phosphates attached to carbon-1 of FDP. A combination of aldolase, transaldolase and sedoheptulose diphosphates may provide an alternative pathway.

The radiation of the Van Allen belts and the solar flares consists primarily of electrons and protons, the biological effects of which are reasonably well known. However, there is a very small component of the galactic cosmic rays which consists of stripped atomic nuclei of atoms as heavy as iron. The biological effects of such particles have not been extensively investigated because it is impossible to produce them in the laboratory with an energy high enough to use for mammalian experiments. Consequently it has been necessary to approach the problem by indirect methods.

Much of the early work in radiation biology was predicted on the assumption that radiation effects could be understood in terms of a single mechanism. This "single mechanism" was studied on appropriate biological test objects that could be developed into biological dosimeters. Attempts were made to assess the properties of "the" biological effects from the relations of "biological dose" (skin dose, bean dose, fly dose, etc.) to physical parameters of irradiation. Notwithstanding the rigidity of this approach, some useful generalizations emerged. During the past 20 years or so, it has become increasingly obvious that ionizing radiations may affect living systems in different ways, and that what is true in one cell, tissue, or species and in one set of circumstances does not necessarily apply to another situation. Accordingly, the search for a single mechanism was replaced by dedicated application to specific detail. In consequence, we now know a great deal about the fine structure of some radiation effects, and there is once again a tendency to formulate generalizations. This paper will attempt to analyze the mechanism of a well-defined syndrome that arises in certain cell systems after a single dose of ionizing radiation. Our attention will be directed mainly to …

Information on the metabolism of fission products in man has been obtained largely from studies carried out with parenterally-administered soluble salts of radioisotopes administered in medical treatment or in tracer studies. The recent development of the whole-body gamma spectrometer with its highly sensitive detection system has been of considerable value in extending these studies by providing data on very low levels of isotopes in man over long periods of time.

The purpose of the Chemo-nuclear In-pile Research Loop is to provide a versatile facility for investigating chemo-nuclear reactions under flow conditions. The loop os designed to handle gaseous systems in conjunction with fixed packages of solid fuel.

During the past year notable progress was made in several laboratories on design for linear accelerators in the energy range up to and above 1 Bev. Interest in linacs for this energy centers on two possible applications: first, as injectors for 300 to 1000 Bev synchrotrons, and second, as sources of intense meson beams. To review this progress, a conference jointly sponsored by the Brookhaven National Laboratory and Yale University was held at Brookhaven during the week of August 20, 1962.

The alternating-gradient proton synchrotrons at CERN and Brookhaven are very similar in size, design and in their experimental use. For this reason, collaboration between the groups at CERN and Brookhaven has been close throughout the history of these two machines. For the most part this has taken the form of exchanges of visits of individual machine designers and of high-energy physicists. By 1962, however, it appeared that the reciprocal flow of information was not adequate and a more formal meeting was arranged. This meeting took place at Brookhaven during the week of September 10, 1962. CERN sent a representative group of machine physicists and high-energy physicists. The meeting was attended also by observers from several American high-energy installations. The discussion covered a wide range of topics, from operating characteristics of the machines themselves to future trends in design of experimental equipment. Plans for beam ejection were presented, techniques were described for better use of secondary beams from internal targets, progress was summarized on dc and rf particle separators. and future trends in neutrino experimentation were predicted.

The Chase two-dimensional analyzer is a 64 channel by 64 channel analyzer with a magnetic drum memory and a buffered storage system. The memory capacity is 2 counts per channel. The maximum storage rate is limited by the drum speed and is about 800 counts per second for a featureless spectrum.

When the nucleus of an atom in a crystalline solid undergoes radiative neutron capture there is disruption of the crystal in the vicinity of the event due to energetic processes accompanying the nuclear transformation. This local disruption has been termed a "hot-zone" or "displacement spike". The chemical state of a transformed recoil atom immediately following transformation is unknown. Within a microsecond the "hot zone" has cooled sufficiently to "freeze" the recoil atom into a stable (or metastable) chemical state. A fraction of the metastable recoil atoms can undergo thermal annealing reactions, and the chemical nature of the metastable state can sometimes be inferred from annealing data. It is characteristic of these reactions that the recoil atoms tend to be reincorporated into the parent chemical form.

The rf particle separator, proposed in 1959 by W.K.H. Panofsky and now in preparation for the Brookhaven Alternating Gradient Synchrotron, required a rf structure which gives a transverse impulse to a passing relativistic particle. In order to produce an accumulative transverse deflection of a traveling charged particle with an electromagnetic field, it is necessary that the field contains a synchronous component and in principle, waveguides and cavities are equivalent with respect to the particle dynamics. It was pointed out by H.G. Hereward, that the electric and magnetic deflection of a transverse electric mode (i.e., with no electric field component parallel to the direction of the particle velocity) cancel exactly at all particle velocities. The deflecting force of a transverse magnetic mode on a synchronous particle with the velocity v is proportional to the factor 1-(v/c)2 and vanishes therefore in the case of relativistic particles.

An additive mechanism of micro- and macro-convective heat transfer was formulated to represent boiling heat transfer with net vapor generation to saturated, non-metallic fluids in convective flow. The final equations are [equations not transcribed]. The second equation will be recognized as the Dittus-Boelter equation with the additional factor F. The two functions F and S are defined as [equations not transcribed] where Re is the effective Reynolds number for the two-phase fluid and ΔTe is the effective superheat for bubble growth. F and S were obtained as functions of the Martinelli parameter and the two-phase Reynolds number, respectively. The correlation was tested with available data for water and organic fluids. Data from different sources which could not be satisfactorily correlated by existing correlations were shown to be quite well correlated by the one presently proposed. The average deviation between calculated and measured boiling coefficients for all data points from nine experimental cases was ±11%

The magnetic field of the AGS ring can contain particles of magnetic rigidity about 34 Bv/c. This includes not only protons of kinetic energy 33 Bev, but also 32 Bev deuterons, 64 Bev alpha particles, and conceivably heavier nuclei such as 188 Bev carbon nuclei. It will be shown in this paper that such nuclei can be injected and accelerated in the AGS if some rather small modifications are made in the injection and acceleration systems. What physics could be done with such beams? Several types of experiments may be suggested. In the first place, since the deuteron is a rather loosely bound combination of a neutron and a proton, it is likely to break up when it hits a target nucleus (stripping reaction). In a considerable fraction of the collisions the neutron will go straight on with essentially unchanged energy (half the deuteron energy). Therefore, with an internal target bombarded by 30 Bev deuterons one should obtain an intense, rather well collimated and monochromatic beam of 15 Bev neutrons in the forward direction.

An air cored pulse deflection coil has been constructed for the Brookhaven AGS. The system produces a deflecting pulse with a peak radial deflection of 2.5 cms and duration of 70 microseconds. Beam spill duration of 15 to 50 microseconds from the target is readily achieved. One deflector has given satisfactory service for over a year and a second unit has been installed this summer.

The studies of Irving and Edgington, and Healy on the synergistic effects of tributyl phosphate (TBP) and tri-n-octylphosphine oxide (TOPO) on the solvent extraction of thorium and other metals by thenoyltrifluoroacetone (TTA) are discussed. It is shown that the synergistic effect is a result of addition reactions as well as replacement reactions and is not a function of the metal being extracted. A compilation of equilibrium constants describing the synergistic effect of TBP and TOPO on TTA extraction is given for the following metal ions: Th4+, UO2,2+, Am2+, Cm3+, Pm3+, Tm3+, and Ca2+.

A computer program which optimizes the locations and strengths of magnets in a beam transport system has been written for the IBM 704 and 7090 computers Programs have been previously written which trace a ray through a system of magnets and determine its focusing properties When using such a program, one examines the characteristics of the emergent beam and then varies the parameters of the system manually to optimize it In the program which will now be described, the computer itself performs the examination and varies the parameters.

The isotopic vapor pressure ratio between monodeuteroethylene and ordinary ethylene has been measured in the temperature range 120°-180°K by differential manometry. The inverse isotope effect with C₂¹²H₃D is less than one‐half the effect observed with the dideuteroethylenes. This deviation from the rule of the geometric mean gives further support to the structural theory of isotopic vapor pressure effects and confirms the importance of quantum corrections of the order of (ℏ/kT)⁴ and higher. Vapor-liquid equilibrium studies of C₂¹²H₄ and C¹²H₂=C¹³H₂ were made in a packed column under total reflux using C₂¹²H₃D as an internal monitor to calibrate the column. Whereas C₂¹²H₃D goes to the top of the column, C¹²H₂=C¹³H₂ concentrates in the boiler. Absolute values of the carbon‐13 effect were calculated from the measured relative effects and the manometric data for C₂¹²H₃D, and the vapor pressure ratios were checked by analysis of the kinetic behavior of the column. A test of the data was made in the framework of the applicable theory. The temperature dependencies of the isotope effects are predicted from the theory within the experimental error. The relative deuterium and carbon‐13 isotope effects as well as the differences between the dideuteroethylene isomers are discussed in terms of the structure …

Four-year-old plants of Taxus media cv. Hatfieldii were exposed to chronic gamma radiation from Co⁶⁰ at daily dose rates of 2.5, 3.75, 7.5, 15, and 30 r per 20-hour day. A dose response curve shows that dose rates as low as 3.75 r per day will reduce significantly the frequency of bud formation. At 12.5 r per day bud formation was reduced to 0.5% of the controls. Histological examination reveals that complete disorganization of the shoot apex occurs after an accumulation of 187.5 r at this low dose rate. Evidence for a pattern of differential sensitivity in the stem apex is presented. The decreasing order of radiosensitivity of the apical regions is: the apical initial layer, lateral initial layer, central mother-cell zone, transition zone, axillary cells and the pith meristem region. This pattern of radiation damage can be described as outer to inner, i.e., the outer cells are the first and the inmost cells are the last to show radiation damage. This response occurs at all dose rates studied above 2.5 r per day. A recovery mechanism frequently is observed at the lower dose rate (2.5 and 3.75 r per day) which leads to the occasional regeneration of a new …

Using the Dirac equation, we consider the contributions to atomic levels of terms quadratic in A. A may be, for example, the nuclear magnetic dipole field. We show that a consistent quantum mechanical treatment cancels all terms arising from [Aᵢ, Aⱼ] ≠ 0. This resolves a disagreement between hyperfine structure corrections calculated nonrelativistically and relativistically.

The ion Co(NH₃)₅Br⁺⁺, labeled with radioactive recoil cobalt or bromine, has been produced in crystals of Co(NH₃)₆Br₃ by five different nuclear transformations. Thermal and radiation annealing reactions of this ion and others formed by recoil have been studied as a function of temperature and the results interpreted in terms of a model which postulates an electron donor-acceptor mechanism. Certain of the experiments yield results which tend to confirm the Varley mechanism for the production of interstitial atoms.