In the general liquid-like binary three radial densities relating to A-A, B-B, and A-B pairs are needed to characterize the scattering. The three densities can be obtained by the Fourier inversion of the weighted combination of three diffraction patterns, each of which differs by the alteration of the scattering of one or both components. If the density of atoms regardless of type is the same around both components, then only two functions, one this distribution, and the other involving the order between A-B pairs is needed to characterize the scattering. This case is the liquid analog of the crystalline alloy with short-range order. These two functions can be obtained by the Fourier inversion of a weighted combination of two patterns differing by the alteration of a weighted combination of two patterns differing by the alteration of the scattering of the components.

Machine calculations have been made of the dynamics of a set of atoms simulating a crystal undergoing radiation damage. Work on copper is reviewed briefly, and its extension to a simple model of ordered Cu₃Au is described. Investigations of lattice agitation in the wake of a damage event and the extent to which a thermal spike model has validity are discussed. Information on point defects and clusters of point defects in copper is another by-product of the calculations. Recent extensions of the calculations to a model of α-iron are provisionally reported. Although a satisfactory interatomic potential has not yet been not found, it appears that the easy direction for production of a displacement is (100) and that the interstitial in this lattice has a split configuration with (110) orientation.

The author presents a literature review of the clinical and experimental investigations into hypertension and phenomena associated with high blood pressure. The author discusses the topics of heredity, angiotensin-aldosterone system, vascular reactivity, ionic gradient and blood pressure, morphological changes, the kidney, sodium, the nervous system, catecholamines, the adrenal cortex, thyroid, antidiuertic hormone, ions other than sodium, obesity, aging, and atherosclerosis and their potential roles in hypertension. The author concludes that while far from understanding hypertension completely, several metabolic abnormalities have been discovered to be associated with hypertension and even play a "causal" role. He suggests that we should look much earlier in the life history of a hypertensive for etiological factors and subtle metabolic abnormalities than we do today.

A computer program which optimizes the locations and strengths of magnets in a beam transport system has been written for the IBM 704 and 7090 computers Programs have been previously written which trace a ray through a system of magnets and determine its focusing properties When using such a program, one examines the characteristics of the emergent beam and then varies the parameters of the system manually to optimize it In the program which will now be described, the computer itself performs the examination and varies the parameters.

Periodically irradiated and annealed graphites show property changes that are markedly different from the changes after the first irradiation and anneal. Evidence is presented indicating the existence of consecutive reactions between interstitial complexes that lead to steady state concentrations of the intermediate species in a chain. The steady state concentrations result in dimensional recoveries and stored energy releases that do not increase with irradiation as they do in continuously irradiated graphites. Interstitial complexes, formed by a thermal anneal, interact through an integral chain via mobile single interstitials. Kinetic equations of chains reacting at one or both ends are described. The calculations for chains reacting at both ends show that large complexes can decompose to form smaller ones. Experimental evidence supporting the calculations shows that periodic removal of the smaller complexes of large amounts of damage associated with the layer interstitials.

Recent reports (1, 2, 3, 4, 5) suggest that the crystalline structure of ice permits unusual forms of energy relationships and that the structured state of water may be of importance in the whole cell. A number of biologically interesting compounds show significantly altered responses to the excitation energy of ultraviolet light in ice as compared to the liquid state. This paper describes the effect of a change in phase state on a biologically active nucleoprotein, a bacteriophage particle. Phage is found to be much more sensitive to inactivation by ultraviolet light when irradiated in frozen aqueous suspension than when irradiated at room temperature (7): the sensitive target appears to be the phage DNA.

The mechanism whereby insulin lowers the blood glucose concentration is currently under extensive investigation. Despite the general agreement that the addition of insulin increases glucose uptake by various isolated tissues, the question has been raised whether administered insulin produces its blood sugar lowering effect in vivo primarily in increasing glucose uptake. Furthermore, it has been suggested that physiologically-released insulin may not exert the same effects as are produced by administered insulin. Attention has also been focused on whether insulin (exogenous or endogenous) exerts its action mainly or entirely on the liver and to what extent insulin influences glucose uptake and glucose production by the liver. The studies to be reported are a continuation of earlier work and are concerned with the effects of insulin, both exogenous and endogenous, on glucose utilization by the tissues and glucose production by the liver under various dietary condition in the unanethetized, intact dog, using C¹⁴ glucose.

The ion Co(NH₃)₅Br⁺⁺, labeled with radioactive recoil cobalt or bromine, has been produced in crystals of Co(NH₃)₆Br₃ by five different nuclear transformations. Thermal and radiation annealing reactions of this ion and others formed by recoil have been studied as a function of temperature and the results interpreted in terms of a model which postulates an electron donor-acceptor mechanism. Certain of the experiments yield results which tend to confirm the Varley mechanism for the production of interstitial atoms.

The purpose of this note is to report various properties of the production modes of K -p interactions at 2.24 Bev/c. Specifically, we present 1) preliminary estimates of the partial cross sections, 2) production angular distributions for those combinations of channels which we believe to be well identified, and 3) for channels of particular interest, we present up-down decay distributions from which hyperon polarization information is obtained. Many of the observed final states which are called "production channels" are in reality the decay products of resonant intermediate states.

Platelet adhesion to the vessel wall and primary thrombus formation was examined by electron microscopy in the anterior pituitary gland of rats given local x irradiation with 8000 r, 24 hours prior to sacrifice. On repeated sectioning, most platelet aggregates or primary mural thrombi showed at least one area where the thrombocytes were attached to the denuded basement membrane. The implications of this finding and the possible mechanisms involved in platelet-endothelial adhesion are discussed.

A study is being made of two-prong antiproton interactions in hydrogen at 3.25 Bev/c. About 2250 two-prong events were measured on automatic digitized machines and their reconstruction and analysis were performed with standard programs. Of the total number of events 1003 were classified as elastic interactions. About 500 inelastic events were examined using bubble density estimates in addition to criteria based on distribution values in the classification procedure. The inelastic events in which a secondary nucleon or antinucleon was unambiguously identified were used to obtain limits for annihilation and non-annihilation partial cross sections. The two-prong events were 57% of the total. Results for angular distributions and cross sections are presented in graphs and tables. (M.C.G.)

A study has been made of 3.25 Bev/c antiproton-proton interactions producing four charged pions in the 20-inch Brookhaven National Laboratory liquid hydrogen bubble chamber. This experiment was performed at the AGS using an electrostatically separated antiproton beam.

In the analysis of the effect of ionizing radiation on living systems, the problem is complicated by the interaction of one part of the system with other parts. If an entire mouse is subjected to radiation, only a few of the most radiosensitive organs, the "weak links," react to the insult and essentially limit the size of the dose delivered since there is little to be learned from irradiating a dead mouse. Thus an insensitive organ like muscle will not respond at all to a total body dose. Likewise, every organ is composed of several different kinds of cells, and the most radiosensitive cells in the organ will determine the reaction observed.

Cell proliferation on the actively growing periosteal surface of the femur of rabbits aged two weeks, has been investigated using autoradiographic techniques. Injections of tritiated glycine and tritiated thymidine were given simultaneously and the animals sacrificed at intervals from one hour to 5 days after injection. The glycine labelled the position of the bone surface at the time of injection and the thymidine labelled the cells which were synthesizing DNA . The rate of increase in the cell population was determined by counting the number of cells beyond the glycine label at different times after injection. The cell kinetics of the fibroblast--pre-osteoblast--osteoblast--osteocyte system has been studied. The fibroblasts are relatively unimportant from the point of view of increase in the cell population. The main site of cell proliferation is the layer of preosteoblasts on the periosteal surface. The rate of movement of cells from the pre-osteoblast to the osteoblast and osteocyte compartments has been measured. The incorporation of osteoblasts into the bone is not a random process, but it appears that the osteoblast must spend a certain time on the periosteal surface before becoming either an osteocyte or a relatively inactive osteoblast lining a haversian canal. During its most active …

A study of the cell kinetics on the actively growing periosteal surface of the femur of rabbits ages two weeks has been continues. A single injection of tritiated thymidine was given and the rabbits killed from one hour to four days after injection. The grain count spectra of the different cell types, pre-osteoblast, osteoblast and osteocyte, have been compared at different times after injection. The results showed evidence for the uptake of thymidine in nuclei which is not associated with cell division. A small percentage of osteoblasts was initially labelled at one hour and there was evidence that the majority of these had not divided by 3 or 4 days after injection. Some thymidine labelled cells had also become osteocytes without division. Furthermore, it appeared that a considerable fraction of the initially labelled pre-osteoblasts did not divide. The S-period for the pre-osteoblasts and osteoblasts was measured using a double-labelled thymidine technique.

In this report we present solutions of the design problem in which a system of quadruple lenses is required to carry a particle beam from given focal lines in the x and y planes to other given focal lines. Particular attention will be given to the case of the anastigmatic lens system which takes a beam from one focal point to another focal point. Since the general problem is almost impossibly complicated a simplification is introduced by breaking the lens system into two parts. The first part of the lens system is required to bring the initial beam to the state where it is parallel to the z axis in both planes. The second part carries the initially parallel beam to the required final condition. Each part will involve two quadrupoles so that the complete system will consist of four quadruples; usually, however, the field gradients in the second and third quadrupoles can be made identical so that those quadrupoles can be combined into one and the system becomes a three quadrupole system. The configuration of the lens element will be as shown in the figures below. These figures indicate also the general character of the beam path in the …

The problem of separation of beams of particles of different masses but of the same momentum at Bev energies is the subject of a great deal of study at several high energy laboratories. In this note we shall describe the problem and tabulate a few of the cogent parameters. Frequently the student of high energy interactions is faced with a beam of miscellaneous particles coming from an accelerator. By standard techniques this beam can be rendered approximately parallel and an inch or so in diameter. By passage through a magnetic field the beam can be analyzed in momentum. Now it frequently happens that the particles in which the experimenter is particularly interested make up only a small fraction of the beam and the exigencies of the proposed experiment may well demand that the background of undesired particles be drastically reduced. The problem is difficult because the velocities of the various particles are almost equal to each other and to the velocity of lights; this makes time-of-flight techniques relatively ineffective. The energies of the particles are almost equal so electrostatic separation also is difficult. Since the beam is already analyzed in momentum, further separation by magnetic means is impossible.

The desired neutron spectrum for the High Flux Beam Reactor under construction at BNL requires use of U-Al fuel elements with more then 30 wt% U235 in the meat. The operating cycle of this reactor requires a minimum burn-up of 20%, and preferably 40% of the uranium in the element.

An additive mechanism of micro- and macro-convective heat transfer was formulated to represent boiling heat transfer with net vapor generation to saturated, non-metallic fluids in convective flow. The final equations are [equations not transcribed]. The second equation will be recognized as the Dittus-Boelter equation with the additional factor F. The two functions F and S are defined as [equations not transcribed] where Re is the effective Reynolds number for the two-phase fluid and ΔTe is the effective superheat for bubble growth. F and S were obtained as functions of the Martinelli parameter and the two-phase Reynolds number, respectively. The correlation was tested with available data for water and organic fluids. Data from different sources which could not be satisfactorily correlated by existing correlations were shown to be quite well correlated by the one presently proposed. The average deviation between calculated and measured boiling coefficients for all data points from nine experimental cases was ±11%

The magnetic field of the AGS ring can contain particles of magnetic rigidity about 34 Bv/c. This includes not only protons of kinetic energy 33 Bev, but also 32 Bev deuterons, 64 Bev alpha particles, and conceivably heavier nuclei such as 188 Bev carbon nuclei. It will be shown in this paper that such nuclei can be injected and accelerated in the AGS if some rather small modifications are made in the injection and acceleration systems. What physics could be done with such beams? Several types of experiments may be suggested. In the first place, since the deuteron is a rather loosely bound combination of a neutron and a proton, it is likely to break up when it hits a target nucleus (stripping reaction). In a considerable fraction of the collisions the neutron will go straight on with essentially unchanged energy (half the deuteron energy). Therefore, with an internal target bombarded by 30 Bev deuterons one should obtain an intense, rather well collimated and monochromatic beam of 15 Bev neutrons in the forward direction.

Cowley's measurements of the short-range order parameters, αi, in Cu3Au at T=405°C have been re-evaluated taking into account the effects of thermal vibrations and static displacements due to differing atomic sizes. The separate corrections for the thermal vibrations and the first-neighbor atomic size factor are found to be quite large, demonstrating their importance in the usual experiments. When combined, the corrections in this case largely cancel, and only the values of α1 and α3 are appreciably changed. The corrected values are: α1= -.113, α2= +.185, α3= -.009, α4= +.082, α5= -.058.

An isochronal differential-type microcalorimeter has been designed and constructed. As a result of its simple design it is very easy to handle the samples and assemble the calorimeter. Important to the operation of the calorimeter is a program, also working on the differential principle, that provides linear temperature rise of the samples. This calorimeter is used to measure very small energy releases such as those found in precipitation, stored energy, etc. It is demonstrated that the calorimeter is easily capable of measuring 0.0005 cal with a probable error of the order of 1% to 2%.

The rf particle separator, proposed in 1959 by W.K.H. Panofsky and now in preparation for the Brookhaven Alternating Gradient Synchrotron, required a rf structure which gives a transverse impulse to a passing relativistic particle. In order to produce an accumulative transverse deflection of a traveling charged particle with an electromagnetic field, it is necessary that the field contains a synchronous component and in principle, waveguides and cavities are equivalent with respect to the particle dynamics. It was pointed out by H.G. Hereward, that the electric and magnetic deflection of a transverse electric mode (i.e., with no electric field component parallel to the direction of the particle velocity) cancel exactly at all particle velocities. The deflecting force of a transverse magnetic mode on a synchronous particle with the velocity v is proportional to the factor 1-(v/c)2 and vanishes therefore in the case of relativistic particles.

The purpose of this paper is to present tables of the perturbed wave functions which have been recently obtained in a calculation of the quadruple antishielding factors γ∞ for the Mn+2, Fe+3, Ga+3, and Ag+ ions. The wave functions v'1(nℓ-ℓ) which are tabulated represent the effect of the perturbation due to a nuclear quadruple moment Q on the wave functions of the outermost electrons of the ion core.