The new and as yet unsolved problems introduced by the production of large quantities of fission products and radioactive isotopes from fission or neutron capture present mankind a most complex technical, economic, and political problem. On one hand, the possibility of using the fission process to produce energy from an unexploited and abundant natural source is emerging from large programs of research and development. We are also beginning to see the promise of use of particulate and electromagnetic radiation for the good of man. On the other hand, we are presented with the problem of controlling the dangerous products of fission for periods of time measured in terms of many hundreds of years, periods longer than the effective tenure of any political state in history. We must not only devise ways of protecting ourselves in the present and for our lifetime but, in addition, we must establish the basic technical, social, and administrative control of vast quantities of artificial radioactivity that must remain effective for at least ten to twenty lifetimes.