This report documents the deactivation, decontamination, decommissioning, and demolition (D4) of eighteen buildings in the 300 Area of the Hanford Site that were demolished in Fiscal Year 2008. The D4 of these facilties included characterization, engineering, removal of hazardous and radiologically contaminated materials, equipment removal, utility disconnection, deactivation, decontamination, demolition of the structure, and stabilization or removal of the remaining slab and foundation, as appropriate.