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Developing a Biomanufacturing Platform for the Site-Selective Functionalization and Structural Diversification of Cytochalasan-Based Carbon Skeletons (open access)

Developing a Biomanufacturing Platform for the Site-Selective Functionalization and Structural Diversification of Cytochalasan-Based Carbon Skeletons

Data management plan for the grant, "Developing a Biomanufacturing Platform for the Site-Selective Functionalization and Structural Diversification of Cytochalasan-Based Carbon Skeletons." This project will identify fungal enzymes that efficiently modify more than one substrate in a predictable way. Also, enzymes will be engineered to expand the range of substrates. A biomanufacturing platform to synthesize bioactive molecules at lower costs will be the end result. Fungi can synthesize small molecules with complex structures using a number of highly coordinated enzymes. These molecules are difficult to make synthetically, and they can aid in crop production or have beneficial human health effects. Cytochalasans are phytotoxic, cytotoxic and actin-binding natural products. Produced by fungi, over 400 variants have been described. The structural diversity is partly explained by the flexibility of the enzymes that introduce and modify functional groups. These enzymes structurally rearrange the core carbon skeleton in a site-selective manner, often on more than one substrate. Genome mining will be used to identify cytochalasan tailoring enzymes. Overproducing strains will be characterized chemically. Transcription factor over-expression will be investigated. Targeted gene knock-out will confirm the function and scope of the enzymes. The enzymes will be engineered to expand their substrate range. Synthetic biology and metabolic …
Date: 2021-03-01/2024-02-29
Creator: Skellam, Elizabeth
Object Type: Text
System: The UNT Digital Library
Turning turtle: scaling relationships and self-righting ability in Chelydra serpentina (open access)

Turning turtle: scaling relationships and self-righting ability in Chelydra serpentina

Article investigating how shell morphology, neck length and self-righting biomechanics scale with body mass during ontogeny in Chelydra serpentina, which uses neck-powered self-righting.
Date: March 3, 2021
Creator: Ruhr, Ilan M.; Rose, Kayleigh A. R.; Sellers, William I.; Crossley, Dane A., II & Codd, Jonathan R.
Object Type: Article
System: The UNT Digital Library
Analyzing Mass Spectrometry Imaging Data of 13C-Labeled Phospholipids in Camelina sativa and Thlaspi arvense (Pennycress) Embryos (open access)

Analyzing Mass Spectrometry Imaging Data of 13C-Labeled Phospholipids in Camelina sativa and Thlaspi arvense (Pennycress) Embryos

This article uses currently available software and techniques to describe a workflow to analyze ¹³C-labeled isotopologues of the membrane lipid and storage oil lipid intermediate—phosphatidylcholine (PC). Results demonstrated greater ¹³C-isotopic labeling in the cotyledons of developing embryos compared with the embryonic axis.
Date: March 4, 2021
Creator: Romsdahl, Trevor B.; Kambhampati, Shrikaar; Koley, Somnath; Yadav, Umesh P.; Alonso, Ana Paula; Allen, Doug K. et al.
Object Type: Article
System: The UNT Digital Library
A window-space-directed assembly strategy for the construction of supertetrahedron-based zeolitic mesoporous metal–organic frameworks with ultramicroporous apertures for selective gas adsorption (open access)

A window-space-directed assembly strategy for the construction of supertetrahedron-based zeolitic mesoporous metal–organic frameworks with ultramicroporous apertures for selective gas adsorption

Article presenting a novel window-space-directed assembly strategy for the synthesis of zeolitic mesoporous MOFs with ultramicroporous apertures based on supertetrahedral building units. This article provides an effective and innovative strategy and paves the way for the future design and synthesis of functional, highly connected materials for various applications.
Date: March 5, 2021
Creator: Zhang, Lei; Li, Fangfang; You, Jianjun; Hua, Nengbin; Wang, Qianting; Si, Junhui et al.
Object Type: Article
System: The UNT Digital Library
Pyrazinacenes exhibit on-surface oxidation-state-dependent conformational and self-assembly behaviours (open access)

Pyrazinacenes exhibit on-surface oxidation-state-dependent conformational and self-assembly behaviours

This article reports pyrazinacenes containing the dihydro-decaazapentacene and dihydro-octaazatetracene chromophores and compares their properties/functions as a model case at an oxidizing metal substrate.
Date: March 10, 2021
Creator: Miklík, David; Mousavi, S. Fatemeh; Burešová, Zuzana; Middleton, Anna; Matsushita, Yoshitaka; Labuta, J. et al.
Object Type: Article
System: The UNT Digital Library
An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants (open access)

An Arabidopsis Oxalyl-CoA Decarboxylase, AtOXC, Is Important for Oxalate Catabolism in Plants

This article identifies, in Arabidopsis, an oxalyl-CoA decarboxylase (AtOXC) that is capable of catalyzing the second step in the proposed pathway of oxalate catabolism.
Date: March 23, 2021
Creator: Foster, Justin; Cheng, Ninghui; Paris, Vincent; Wang, Lingfei; Wang, Jin; Wang, Xiaoqiang et al.
Object Type: Article
System: The UNT Digital Library
Covalent organic framework nanofluidic membrane as a platform for highly sensitive bionic thermosensation (open access)

Covalent organic framework nanofluidic membrane as a platform for highly sensitive bionic thermosensation

Article reporting a nanofluidic membrane based on an ionic covalent organic framework (COF) that is capable of intelligently monitoring temperature variations and expressing it in the form of continuous potential differences. This article pioneers a way to explore COFs for mimicking the sophisticated signaling system observed in the nature.
Date: March 23, 2021
Creator: Zhang, Pengcheng; Chen, Sifan; Zhu, Changjia; Hou, Linxiao; Xian, Weipeng; Zuo, Xiuhui et al.
Object Type: Article
System: The UNT Digital Library
Theoretical modeling study of the reaction H + CF4 → HF + CF3 (open access)

Theoretical modeling study of the reaction H + CF4 → HF + CF3

This article determines the rate constant of the reaction H + CF₄ → HF + CF₃, characterizing its transition state by quantum-chemical methods.
Date: March 23, 2021
Creator: Cobos, Carlos J.; Knight, Gary; Marshall, Paul & Troe, Jürgen
Object Type: Article
System: The UNT Digital Library
Accelerated reliability testing of Cu-Al bimetallic contact by a micropattern corrosion testing platform for wire bond device application (open access)

Accelerated reliability testing of Cu-Al bimetallic contact by a micropattern corrosion testing platform for wire bond device application

This article presents a novel method of in-situ investigation of the device corrosion process to capture the real time mechanistic information not obtained in standard reliability testing.
Date: March 26, 2021
Creator: Ashok Kumar, Goutham Isaac; Alptekin, John; Caperton, Joshua; Salunke, Ashish & Chyan, Oliver Ming-Ren
Object Type: Article
System: The UNT Digital Library
Green synthesis of olefin-linked covalent organic frameworks for hydrogen fuel cell applications (open access)

Green synthesis of olefin-linked covalent organic frameworks for hydrogen fuel cell applications

This article creates a green strategy to fabricate a highly crystalline olefin-linked pyrazine-based covalent organic framework (COF) with high robustness and porosity under solvent-free conditions. This study opens up new possibilities for the green synthesis of advanced materials and provides important guidance for the rational design and synthesis of polymeric materials for proton-exchange membrane fuel cell applications.
Date: March 31, 2021
Creator: Wang, Zhifang; Yang, Yi; Zhao, Zhengfeng; Zhang, Penghui; Zhang, Yushu; Liu, Jinjin et al.
Object Type: Article
System: The UNT Digital Library