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A novel benzimidazole derivative, MBIC inhibits tumor growth and promotes apoptosis via activation of ROS-dependent JNK signaling pathway in hepatocellular carcinoma
This study further explores a prior screening program carried out using MTT assay that identified a series of novel benzimidazole derivatives, among which Methyl 2-(5-fluoro-2-hydroxyphenyl)-1H-benzo[d]imidazole-5-carboxylate (MBIC) showed highest anticancer efficacy compared to that of chemotherapeutic agent, cisplatin. In this article, the authors find that MBIC inhibited cell viability in different hepatocellular carcinoma (HCC) cell lines without exerting significant cytotoxic effects on normal liver cells. The results of this study demonstrate that MBIC may inhibit cell proliferation via ROS-mediated activation of the JNK signaling cascade in HCC cells.
Date:
January 12, 2017
Creator:
Dai, Xiaoyun; Wang, Ling Zhi; Deivasigamni, Amudha; Looi, Chung Yeng; Karthikeyan, Chandrabose; Trivedi, Piyush et al.
Object Type:
Article
System:
The UNT Digital Library
Environmental vibrios represent a source of antagonistic compounds that inhibit pathogenic Vibrio cholerae and Vibrio parahaemolyticus strains
This article predicts that marine-derived bacteria should inhibit Vibrio pathogens and may be a source of unique antibiotic compounds.
Date:
March 10, 2017
Creator:
Burks, David J.; Norris, Stephen; Kauffman, Kathryn M.; Joy, Abigail; Arevalo, Philip; Azad, Rajeev K. et al.
Object Type:
Article
System:
The UNT Digital Library
Existence and Nonexistence of Solutions for Sublinear Problems With Prescribed Number of Zeros on Exterior Domains
This article proves the existence of radial solutions of Δu + K(r)ƒ(u) = 0 on the exterior of the ball, of radius R, centered at the origin in ℝᴺ such that limᵣ→∞u(r) = 0 if R > 0 is sufficiently small.
Date:
May 16, 2017
Creator:
Joshi, Janak
Object Type:
Article
System:
The UNT Digital Library
Brassinosteroid Mediated Cell Wall Remodeling in Grasses Under Abiotic Stress
This article focuses on recent advances in brassinosteroid-regulated cell wall biosynthesis and remodeling in response to stresses, comparing the authors' understanding of the mechanisms in grass species with those in the more studied dicots.
Date:
May 17, 2017
Creator:
Rao, Xiaolan & Dixon, R. A.
Object Type:
Article
System:
The UNT Digital Library
Genetically engineered probiotic for the treatment of phenylketonuria (PKU); assessment of a novel treatment in vitro and in the PAHᵉⁿᵘ² mouse model of PKU
This article describes the testing of a phenylalanine lyase gene from Anabaena variabilis (AvPAL) codon-optimized and cloned into a shuttle vector for expression in Lactobacillus reuteri 100-23C (pHENOMMenal).
Date:
May 17, 2017
Creator:
Durrer, Katherine E.; Allen, Michael S. & Hunt von Herbing, Ione
Object Type:
Article
System:
The UNT Digital Library
Commentary on "Correlation of solubility of hexamethylene-1,6-bisthiosulphate disodium salt dihydrate versus dielectric constants of water + ethanol mixtures"
This article discusses the finding that Apelblat model equation coefficients are found to give calculated mole fractions that exceed unity for the solubility of hexamethylene-1,6-bisthiosulphate disodium salt dihydrate dissolved in binary aqueous-ethanol solvent mixtures.
Date:
May 19, 2017
Creator:
Acree, William E. (William Eugene) & Yang, Chunhui
Object Type:
Article
System:
The UNT Digital Library
Further Calculations on Solubility of 2-Chloro-3-(Trifluoromethyl)Pyridine in Ethanol + 1-Propanol Solvent Mixtures at Various Temperatures
This article reports on the reanalysis of reported calculations on solubility data of 2-chloro-3-(trifluoromethyl)pyridine in binary ethanol + 1-propanol solvent mixtures at various temperatures, and several additional points regarding the correlations.
Date:
May 25, 2017
Creator:
Jouyban, Abolghasem; Martínez, Fleming & Acree, William E. (William Eugene)
Object Type:
Article
System:
The UNT Digital Library
Computational investigation of O₂ diffusion through an intra-molecular tunnel in AlkB; influence of polarization on O₂ transport
This article discusses the use of computational simulations to investigate possible migration pathways inside AlkB for O₂ molecules.
Date:
March 3, 2017
Creator:
Torabifard, Hedieh & Cisneros, Gerardo Andrés
Object Type:
Article
System:
The UNT Digital Library
Self-organizing Complex Networks: individual versus global rules
This article introduces a form of Self-organized Criticality (SOC) inspired by the new generation of evolutionary game theory, which ranges from physiology to sociology.
Date:
June 7, 2017
Creator:
Mahmoodi, Korosh; West, Bruce J. & Grigolini, Paolo
Object Type:
Article
System:
The UNT Digital Library
Dioxygen: What Makes This Triplet Diradical Kinetically Persistent?
This article examines experimental heats of formation and enthalpies obtained from G4 calculations to find that the resonance stabilization of the two unpaired electrons in triplet O₂, relative to the unpaired electrons in two hydroxyl radicals, amounts to 100 kcal/mol.
Date:
April 26, 2017
Creator:
Borden, Weston T.; Hoffmann, Roald; Stuyver, Thijs & Chen, Bo
Object Type:
Article
System:
The UNT Digital Library
Black Hole Growth Is Mainly Linked to Host-galaxy Stellar Mass Rather Than Star Formation Rate
This article investigates the dependence of black hole accretion rate (BHAR) on host-galaxy star formation rate (SFR) and stellar mass in the CANDELS/GOODS-South field in the redshift range of 0.5 ⩽ z < 2.0.
Date:
June 15, 2017
Creator:
Yang, G.; Chen, C. -T. J.; Vito, F.; Brandt, William Nielsen; Alexander, David M.; Luo, Bin et al.
Object Type:
Article
System:
The UNT Digital Library
Commentary on “Experimental Measurements and Equilibrium Study of Functional D-Sorbitol in Good and Anti-Solvent Binary Mixtures”
This article provides a commentary on the published equation coefficients for mathematically describing the solubility behavior of D-sorbitol in binary acetonitrile + ethanol solvent mixtures using the modified Apelblat, Combined Nearly Ideal Binary Solvent/Redlich-Kister (CNIBS/R-K) and Jouyban-Acree models.
Date:
May 11, 2017
Creator:
Acree, William E. (William Eugene)
Object Type:
Article
System:
The UNT Digital Library
Badly approximable points on self-affine sponges and the lower Assouad dimension
This article highlights a connection between Diophantine approximation and the lower Assouad dimension by using information about the latter to show that the Hausdorff dimension of the set of badly approximable points that lie in certain non-conformal fractals, known as self-affine sponges, is bounded below by the dynamical dimension of these fractals. The results, which are the first to advance beyond the conformal setting, encompass both the case of Sierpiński sponges/carpets (also known as Bedford–McMullen sponges/carpets) and the case of Barański carpets.
Date:
June 20, 2017
Creator:
Das, Tushar; Fishman, Lior; Simmons, David & Urbański, Mariusz
Object Type:
Article
System:
The UNT Digital Library
Commentary on “Studies on Molar Volume, Dielectric Properties and Refractive Indices of Cyanex 923 + Benzene/Xylene at 300 K”
This article provides a commentary on Redlich-Kister equation coefficients for binary benzene + cyanex 923 and xylene + cyanex 923.
Date:
May 4, 2017
Creator:
Acree, William E. (William Eugene)
Object Type:
Article
System:
The UNT Digital Library
Cardiorespiratory physiological phenotypic plasticity in developing air-breathing anabantid fishes (Betta splendens and Trichopodus trichopterus)
This article discusses development plasticity of cardiorespiratory physiology in two air-breathing anabantid fishes.
Date:
June 16, 2017
Creator:
Mendez-Sanchez, Jose F. & Burggren, Warren W.
Object Type:
Article
System:
The UNT Digital Library
Calculation of Five Thermodynamic Molecular Descriptors by Means of a General Computer Algorithm Based on the Group-Additivity Method: Standard Enthalpies of Vaporization, Sublimation and Solvation, and Entropy of Fusion of Ordinary Organic Molecules and Total Phase-Change Entropy of Liquid Crystals
This article presents the calculation of the standard enthalpies of vaporization, sublimation and solvation of organic molecules using a common computer algorithm on the basis of a group-additivity method.
Date:
June 25, 2017
Creator:
Naef, Rudolf & Acree, William E. (William Eugene)
Object Type:
Article
System:
The UNT Digital Library
Gold at What Cost? Another Megaproject Threatens Biodiversity in the Amazon
This article summarizes three controversial aspects of the Volta Grande project.
Date:
March 24, 2017
Creator:
Tófoli, Raffael M.; Dias, Rosa M.; Alves, Gustavo H. Zaia; Hoeinghaus, David; Gomes, Luiz C.; Baumgartner, Matheus T. et al.
Object Type:
Article
System:
The UNT Digital Library
Gold at what cost? Another megaproject threatens biodiversity in the Amazon
Article discusses concerns and controversy related to the gold mining ‘Volta Grande Project’ at the Xingu River in northern Brazil.
Date:
June 26, 2017
Creator:
Tófoli, Raffael M.; Dias, Rosa M.; Alves, Gustavo H. Zaia; Hoeinghaus, David J.; Gomes, Luiz C.; Baumgartner, Matheus T. et al.
Object Type:
Article
System:
The UNT Digital Library
Heart Performance Determination by Visualization in Larval Fishes: Influence of Alternative Models for Heart Shape and Volume
This article assesses the validity of three different heart models applied to digital images of complete cardiac cycles in larval mahi-mahi and red drum.
Date:
July 4, 2017
Creator:
Perrichon, Prescilla; Grosell, Martin & Burggren, Warren W.
Object Type:
Article
System:
The UNT Digital Library
The role of the 5f valence orbitals of early actinides in chemical bonding 5f valence orbiatls of early actinides in chemical bonding
This article illuminates the role of the 5f valence orbitals of uranium, neptunium and plutonium in chemical bonding using advanced spectroscopies.
Date:
July 6, 2017
Creator:
Vitova, T.; Pidchenko, I.; Fellhauer, D.; Bagus, Paul S.; Joly, Y.; Pruessmann, T. et al.
Object Type:
Article
System:
The UNT Digital Library
Toward a More Rational Design of the Direct Synthesis of Aniline: A Density Functional Theory Study
This article uses plane-wave density functional theory calculations to investigate the direct amination of benzene catalyzed by a Ni(111) surface to explore the reaction intermediates and to understand the role of nickel in this reaction.
Date:
March 24, 2017
Creator:
Alsunaidi, Zainab H. A.; Cundari, Thomas R., 1964- & Wilson, Angela K.
Object Type:
Article
System:
The UNT Digital Library
Developmental Transcriptomic Analyses for Mechanistic Insights Into Critical Pathways Involved in Embryogenesis of Pelagic Mahi-Mahi (Coryphaena Hippurus)
This article characterizes the developmental transcriptome of mahi-mahi by means of high throughput sequencing at three critical developmental stages.
Date:
July 10, 2017
Creator:
Xu, Elvis Genbo; Mager, Edward M.; Grosell, Martin; Stieglitz, John D.; Hazard, E. Starr; Hardiman, Gary et al.
Object Type:
Article
System:
The UNT Digital Library
Art therapy and music reminiscence activity in the prevention of cognitive decline: study protocol for a randomized controlled trial
This article explores the feasibility of using art therapy and music reminiscence activity to improve the cognition of community living elderly with mild cognitive impairment.
Date:
July 12, 2017
Creator:
Mahendran, Rathi; Rawtaer, Iris; Fam, Johnson; Wong, Jonathan; Kumar, Alan PremSingapore Clinical Research Institute, Duke-NUS Medical School, University of Tampere, Tampere University Hospital; Gandhi, Mihir et al.
Object Type:
Article
System:
The UNT Digital Library
Genome Sequences of Five Streptomyces Bacteriophages Forming Cluster BG
This article discusses the isolation of five novel phages, which were used to established the cluster BF, using Streptomyces griseus subsp. griseus strain ATcC 10137 as the host.
Date:
July 13, 2017
Creator:
Donegan-Quick, Richard; Gibbs, Zane A.; Amaku, Patricia O.; Bernal, Joshua T.; Boyd, Dana A. M.; Burr, Angela R. et al.
Object Type:
Article
System:
The UNT Digital Library