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Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals
Article evaluating the response to the pharmacological compounds Fluoxetine, Muscimol, and Verapamil in primary neuronal cultures. Final conclusions are drawn that MEA technology has a potential for standard in vitro neurotoxicity/neuropharmacology evaluation.
Date:
April 27, 2011
Creator:
Novellino, A.; Scelfo, Bibiana; Palosaari, T.; Price, A.; Sobanski, Tomasz; Shafer, T.J. et al.
System:
The UNT Digital Library
Lipoxygenase-mediated Oxidation of Polyunsaturated N-Acylethanolamines in Arabidopsis
Article hypothesizing that lipoxygenase (LOX) participated in the metabolism of PU-NAEs through the formation of NAE-oxylipins. The data suggests that Arabidopsis LOXs indeed compete with FAAH to metabolize PU-NAEs during seedling establishment. Identification of endogenous amide-conjugated oxylipins suggests potential significance of these metabolites in vivo, and FAAH mutants may offer opportunities to address this in the future.
Date:
April 29, 2011
Creator:
Kilaru, Aruna; Herrfurth, Cornelia; Keereetaweep, Jantana; Hornung, Ellen; Venables, Barney J.; Feussner, Ivo et al.
System:
The UNT Digital Library