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Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2 (open access)

Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2

Article reporting that PAK2, a member of the Rho family of GTPase-dependent kinases, regulates isometric tension development and myosin II RLC phosphorylation in saponin permeabilized endothelial monolayers. The results demonstrate that PAK2 can directly phosphorylate MLCK, inhibiting its activity and limiting the development of isometric tension.
Date: June 16, 2000
Creator: Goeckeler, Zoe M.; Masaracchia, Ruthann A.; Zeng, Qi; Chew, Teng-Leong; Gallagher, Patricia & Wysolmerski, Robert B.
System: The UNT Digital Library