N-acylethanolamide metabolizing enzymes are upregulated in human neural progenitor-derived neurons exposed to sub-lethal oxidative stress (open access)

N-acylethanolamide metabolizing enzymes are upregulated in human neural progenitor-derived neurons exposed to sub-lethal oxidative stress

Article is a study determining whether ReN cells, a superior cell model system for studying neurodevelopment, differentiation, and neuroprotection, express proteins involved in canonical eCB NAE signaling and whether oxidative stress can induce their expression. This study is a first step toward determining how oxidative stress affects CB1, CB2, FAAH, NAAA, and NAPE-PLD expression and their potential defense against oxidative stress.
Date: August 8, 2022
Creator: Duncan, Scott R.; Riordan, Sean M.; Hall, Conner W.; Payne, Andrew J.; Chapman, Kent Dean & Koulen, Peter
System: The UNT Digital Library
Case report: Early-onset osteoporosis in a patient carrying a novel heterozygous variant of the WNT1 gene (open access)

Case report: Early-onset osteoporosis in a patient carrying a novel heterozygous variant of the WNT1 gene

Article presents a case study of a 35 year-old Caucasian woman who experienced multiple vertebral fractures two months after her second pregnancy. The results suggest a potential role of heterozygous WNT1 variants in the pathogenesis of early-onset osteoporosis. The authors suggest that teriparatide is one of the most appropriate available therapies for such cases.
Date: August 8, 2022
Creator: Campopiano, Maria Cristina; Fogli, Antonella; Michelucci, Angela; Mazoni, Laura; Longo, Antonella; Borsari, Simona et al.
System: The UNT Digital Library
Editorial: Microbial C1 Metabolism and Biotechnology (open access)

Editorial: Microbial C1 Metabolism and Biotechnology

This article is an editorial on the research topic Microbial C1 Metabolism and Biotechnology. This special topic presents studies focused on the fundamental aspects of C1 metabolism in diverse microbial systems with the ability to convert anthropogenic greenhouse gases into valuable products.
Date: August 27, 2021
Creator: Xiong, Wei; Kalyuzhnaya, Marina G. & Henard, Calvin
System: The UNT Digital Library
Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators (open access)

Epigenetic reprogramming converts human Wharton's jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

This article studies the differentiation of human Wharton's jelly mesenchymal stem cells into the cardiomyocyte lineage via epigenetic manipulations.
Date: May 24, 2017
Creator: Bhuvanalakshmi, G.; Arfuso, Frank; Kumar, Alan Prem; Dharmarajan, Arunasalam & Warrier, Sudha R.
System: The UNT Digital Library
Occurrence of excited state charge separation in a N-doped graphene–perylenediimide hybrid formed via ‘click’ chemistry (open access)

Occurrence of excited state charge separation in a N-doped graphene–perylenediimide hybrid formed via ‘click’ chemistry

Article describes study in which researchers, using click chemistry, synthesized a donor–acceptor hybrid comprised of N-doped graphene and perylenediimide (PDI), a well-known electron-accepting photosensitizer.
Date: August 30, 2019
Creator: Gobeze, Habtom B.; Arellano, Luis M.; Gutiérrez-Vílchez, Ana María; Gómez-Escalonilla, María J.; Sastre-Santos, Ángela; Fernández-Lázaro, Fernando et al.
System: The UNT Digital Library
Proanthocyanidin Biosynthesis—a Matter of Protection (open access)

Proanthocyanidin Biosynthesis—a Matter of Protection

Article discussing key questions and opportunities in the field of Proanthocyanidins (PA) biosynthesis.
Date: August 18, 2020
Creator: Dixon, R. A. & Sarnala, Sai
System: The UNT Digital Library
Elucidating the role of negative parenting in the genetic v. environmental influences on adult psychopathic traits (open access)

Elucidating the role of negative parenting in the genetic v. environmental influences on adult psychopathic traits

Article states that though adult psychopathic traits emerge from both genetic and environmental risk, no studies have examined etiologic associations between adult psychopathic traits and experiences of parenting in childhood, or the extent to which parenting practices may impact the heritability of adult psychopathic traits using a genetically-informed design. Utilizing a genetically-informed design, the authors found that both genetic and non-shared environmental factors contribute to the emergence of psychopathic traits.
Date: August 12, 2021
Creator: Dotterer, Hailey L.; Vazquez, Alexandra Y.; Hyde, Luke W.; Neumann, Craig S.; Santtila, Pekka; Pezzoli, Patrizia et al.
System: The UNT Digital Library
Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids (open access)

Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids

Article summarises the known structures, biological activities, and biosynthetic pathways of the tropolone sesquiterpenoid family of fungal secondary metabolites. Synthesis of this knowledge allows likely structural and stereochemical misassignments to be revised and shows how the compounds can be divided into three main biosynthetic classes based on the stereochemistry of key biosynthetic steps.
Date: August 31, 2022
Creator: Li, Lei & Cox, Russell, J.
System: The UNT Digital Library
Model checking via testing for direct effects in Mendelian Randomization and transcriptome-wide association studies (open access)

Model checking via testing for direct effects in Mendelian Randomization and transcriptome-wide association studies

This article proposes a new and general goodness-of-fit (GOF) test, called TEDE (TEsting Direct Effects), applicable to both correlated and independent SNPs/IVs as commonly used in transcriptome-wide association studies (TWAS) and Mendelian randomization (MR) respectively.
Date: August 2, 2021
Creator: Deng, Yangqing & Pan, Wei
System: The UNT Digital Library
Inadequate thermal refuge constrains landscape habitability for a grassland bird species (open access)

Inadequate thermal refuge constrains landscape habitability for a grassland bird species

This article uses the northern bobwhite (Colinus virginianus) as a model species for studying how microclimates serve as refuge against severe weather conditions.
Date: April 11, 2017
Creator: Tomecek, John M.; Pierce, Brian L.; Reyna, Kelly S. & Peterson, Markus J.
System: The UNT Digital Library
Development of Neutral Red as a pH/pCO2 Luminescent Sensor for Biological Systems (open access)

Development of Neutral Red as a pH/pCO2 Luminescent Sensor for Biological Systems

This article demonstrates for the first time that Neutral Red (NR) can also serve as a CO2 sensor, because of NR’s unique optical properties, which change with dissolved carbon dioxide (dCO2) concentrations. In this article optical sensitivity of NR was quantified as a function of changes in absorption and emission spectra to dCO2 in a pH 7.3 buffer medium at eight dCO2 concentrations.
Date: August 5, 2021
Creator: Ericson, Megan N.; Shankar, Sindhu K.; Chahine, Laya M.; Omary, Mohammad A.; Hunt von Herbing, Ione & Marpu, Sreekar
System: The UNT Digital Library
Reactions of triosmium and triruthenium clusters with 2-ethynylpyridine: new modes for alkyne C–C bond coupling and C–H bond activation (open access)

Reactions of triosmium and triruthenium clusters with 2-ethynylpyridine: new modes for alkyne C–C bond coupling and C–H bond activation

Article investigates the reaction of the trimetallic clusters [H₂Os₃(CO)₁₀] and [Ru₃(CO)₁₀L₂] (L = CO, MeCN) with 2-ethynylpyridine.
Date: August 19, 2020
Creator: Richmond, Michael G.; Joy, Tuhinur R.; Roknuzzaman; Hossain, Emdad; Ghosh, Shishir; Tocher, Derek A. et al.
System: The UNT Digital Library
Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers (open access)

Oral Spore-Based Probiotic Supplementation Was Associated With Reduced Incidence of Post-Prandial Dietary Endotoxin, Triglycerides, and Disease Risk Biomarkers

This article contains a study to determine if 30-d of oral spore-based probiotic supplementation could reduce dietary endotoxemia.
Date: January 26, 2017
Creator: McFarlin, Brian K.; Henning, Andrea L.; Bowman, Erin M.; Gary, Melody A. & Carbajal, Kimberly M.
System: The UNT Digital Library
Systematic Comparison of Power Corridor Classification Methods from ALS Point Clouds (open access)

Systematic Comparison of Power Corridor Classification Methods from ALS Point Clouds

Study examines factors that affect power corridor classification using LiDAR (light detection and ranging) point clouds, including the class distribution, feature selection, classifier type and neighborhood radius for classification feature extraction.
Date: August 21, 2019
Creator: Peng, Shuwen; Xi, Xiaohuan; Wang, Cheng; Dong, Pinliang; Wang, Pu & Nie, Sheng
System: The UNT Digital Library
An Updated Understanding of Texas Bumble Bee (Hymenoptera: Apidae) Species Presence and Potential Distributions in Texas, Usa (open access)

An Updated Understanding of Texas Bumble Bee (Hymenoptera: Apidae) Species Presence and Potential Distributions in Texas, Usa

This article aims to update existing Texas bumble bee presence databases, model statewide species distributions, and identify conservation target areas.
Date: August 10, 2017
Creator: Beckham, Jessica L. & Atkinson, Samuel F.
System: The UNT Digital Library
Metal–Organic Frameworks for Enzyme Immobilization: Beyond Host Matrix Materials (open access)

Metal–Organic Frameworks for Enzyme Immobilization: Beyond Host Matrix Materials

Article reviews current research of role/function diversities of host matrix metal–organic frameworks (MOFs), noting the importance of understanding enzyme structural alternation and enzyme−MOF interaction after immobilization.
Date: August 27, 2020
Creator: Wang, Xiaoliang; Lan, Pui Ching & Ma, Shengqian
System: The UNT Digital Library
Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase (RubisCO) Is Essential for Growth of the Methanotroph Methylococcus capsulatus Strain Bath (open access)

Ribulose-1,5-Bisphosphate Carboxylase/Oxygenase (RubisCO) Is Essential for Growth of the Methanotroph Methylococcus capsulatus Strain Bath

This article demonstrates that shows both CO2 and RubisCO are essential for M. capsulatus Bath growth. CO2 tracing experiments supported that RubisCO mediates CO2 fixation and that a noncanonical Calvin cycle is active in this organism. The study provides insights into the expanding knowledge of methanotroph metabolism and implicates dually CH4/CO2-utilizing bacteria as more important players in the biogeochemical carbon cycle than previously appreciated. In addition, M. capsulatus and other methanotrophs with CO2 assimilation capacity represent candidate organisms for the development of biotechnologies to mitigate the two most abundant greenhouse gases, CH4 and CO2.
Date: August 26, 2021
Creator: Henard, Calvin; Wu, Chao; Xiong, Wei; Henard, Jessica M.; Davidheiser-Kroll, Brett; Orata, Fabini D. et al.
System: The UNT Digital Library
Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green (open access)

Amplification of photoacoustic effect in bimodal polymer particles by self-quenching of indocyanine green

This article presents a new type of bimodal contrast agent that is based on the self-quenching of indocyanine green (ICG) encapsulated in a biocompatible and biodegradable polymer shell.
Date: August 23, 2019
Creator: Mokrousov, Maksim D.; Novoselova, Marina V.; Nolan, Jackie; Harrington, Walter; Rudakovskaya, Polina; Bratashov, Daniil N. et al.
System: The UNT Digital Library
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas (open access)

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Article identifies exceptional glucose reliance among squamous cell carcinomas (SCC)s dictated by hyperactive GLUT1-mediated glucose influx.
Date: August 13, 2019
Creator: Hsieh, Meng-Hsiung; Choe, Joshua H.; Gadhvi, Jashkaran; Kim, Yoon Jung; Arguez, Marcus A.; Palmer, Madison et al.
System: The UNT Digital Library
Porphyrinoid rotaxanes: building a mechanical picket fence (open access)

Porphyrinoid rotaxanes: building a mechanical picket fence

This article describes the active template CuAAC synthesis of interlocked triazole functionalised porphyrinoids in excellent yield.
Date: August 3, 2017
Creator: Ngo, T. H.; Labuta, J.; Lim, G. N.; Webre, W. A.; D'Souza, Francis; Karr, P. A. et al.
System: The UNT Digital Library
N-Doped graphene/C₆₀ covalent hybrid as a new material for energy harvesting applications (open access)

N-Doped graphene/C₆₀ covalent hybrid as a new material for energy harvesting applications

This article systematically investigates the degree of functionalization and the key structural features of the N-G/C₆₀ hybrid by a number of techniques including thermogravimetric analysis, X-ray photoelectron and Raman spectroscopies and transmission electron and atomic force microscopies.
Date: August 26, 2018
Creator: Barrejón, Myriam; Arellano, Luis M.; Gobeze, Habtom B.; Gómez-Escalonilla, María J.; Fierro, Jose Luis G.; D'Souza, Francis et al.
System: The UNT Digital Library
Numerical Investigation of Dynamical and Morphological Trends in Relativistic Jets (open access)

Numerical Investigation of Dynamical and Morphological Trends in Relativistic Jets

Article investigates the connection of kiloparsec scale AGN jet properties to their intrinsic parameters and surroundings. This is the accepted manuscript version of the article.
Date: August 2022
Creator: Mandal, Soham; Duffell, Paul C. & Li, Yuan
System: The UNT Digital Library
A gene based approach to test genetic association based on an optimally weighted combination of multiple traits (open access)

A gene based approach to test genetic association based on an optimally weighted combination of multiple traits

In this article, the authors propose a statistical method by Testing an Optimally Weighted Combination of Multiple traits (TOW-CM) to test the association between multiple traits and multiple variants in a genomic region (a gene or pathway). They investigate the performance of the proposed method through extensive simulation studies. Their simulation studies show that the proposed method has correct type I error rates and is either the most powerful test or comparable with the most powerful tests. Additionally, they illustrate the usefulness of TOW-CM based on a COPDGene study.
Date: August 9, 2019
Creator: Zhang, Jianjun; Sha, Qiuying; Liu, Guanfu & Wang, Xuexia
System: The UNT Digital Library
High degree of non-genetic phenotypic variation in the vascular system of crayfish: a discussion of possible causes and implications (open access)

High degree of non-genetic phenotypic variation in the vascular system of crayfish: a discussion of possible causes and implications

This article studies the hemolymph vascular system (HVS) in two cambarid crayfishes, i.e. the Marbled Crayfish, Procambarus virginalis Lyko, 2017 and the Spiny Cheek Crayfish, Faxonius limosus (Rafinesque, 1817) in regard to areas of non-genetic phenotypic variation.
Date: August 12, 2021
Creator: Scholz, Stephan; Göpel, Torben; Richter, Stefan & Wirkner, Christian S.
System: The UNT Digital Library