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A cytoskeletal function for PBRM1 reading methylated microtubules
This article shows that that the coordinated read-write activity of the epigenetic machinery extends to the cytoskeleton, with PBRM1 in the PBAF chromatin remodeling complex reading microtubule methyl marks written by the SETD2 histone methyltransferase. This article opens a previously unknown window into how chromatin remodeler defects can drive disease via both epigenetic and cytoskeletal dysfunction.
Date:
April 2, 2021
Creator:
Karki, Menuka; Jangid, Rahul K.; Anish, Ramakrishnan; Seervai, Riyad N. H.; Bertocchio, Jean-Phillipe; Hotta, Takashi et al.
System:
The UNT Digital Library