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Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions (open access)

Preferential Solvation Study of Rosuvastatin in the {PEG400 (1) + Water (2)} Cosolvent Mixture and GastroPlus Software-Based In Vivo Predictions

Article claims that rosuvastatin (RST) is a poorly water-soluble drug responsible for limited in vivo dissolution and subsequently low oral systemic absorption (poor bioavailability). The results of inverse Kirkwood–Buff integrals showed the PS of RST by PEG400 as observed in all studied ratios of the binary mixture.
Date: March 28, 2023
Creator: Hussain, Afzal; Afzal, Obaid; Yasmin, Sabina; Haider, Nazima; Alfawaz Altamimi, Abdulmalik Saleh; Martínez, Fleming et al.
System: The UNT Digital Library
A multiscale approach reveals elaborate circulatory system and intermittent heartbeat in velvet worms (Onychophora) (open access)

A multiscale approach reveals elaborate circulatory system and intermittent heartbeat in velvet worms (Onychophora)

Article describes how an antagonistic hemolymph-muscular system is essential for soft-bodied invertebrates. The authors analyzed the entire circulatory system of the peripatopsid Euperipatoides rowelli and claimed they discovered a surprisingly elaborate organization.
Date: April 28, 2023
Creator: Jahn, Henry; Hammel, Jörg U.; Göpel, Torben; Wirkner, Christian S. & Mayer, Georg
System: The UNT Digital Library
Complexity Synchronization of Organ Networks (open access)

Complexity Synchronization of Organ Networks

Article describes how the transdisciplinary nature of science as a whole became evident as the necessity for the complex nature of phenomena to explain social and life science, along with the physical sciences, blossomed into complexity theory and most recently into complexitysynchronization. The authors use the scaling of empirical datasets from the brain, cardiovascular and respiratory networks to support the hypothesis that complexity synchronization occurs between scaling indices or equivalently with the matching of the time dependencies of the networks' multifractal dimensions.
Date: September 28, 2023
Creator: West, Bruce J.; Grigolini, Paolo; Kerick, Scott E.; Franaszczuk, Piotr J. & Mahmoodi, Korosh
System: The UNT Digital Library