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In vivo Evaluation of Non-viral NICD Plasmid-Loaded PLGA Nanoparticles in Developing Zebrafish to Improve Cardiac Functions
This article presents a study with the purpose to deliver a Notch Intracellular Domain (NICD)-encoded plasmid via poly(lactic-co-glycolic acid) (PLGA) nanoparticles and to investigate the toxic environmental side effects for an in vivo experiment. This research demonstrates that PLGA nanoparticle-mediated target delivery to upregulate Notch related genes can be a potential therapeutic approach with minimum toxic effects.
Date:
February 23, 2022
Creator:
Messerschmidt, Victoria L.; Chintapula, Uday; Bonetesta, Fabrizio; Laboy-Segarra, Samantha; Naderi, Amir; Nguyen, Kytai T. et al.
System:
The UNT Digital Library
Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles
Article uses acid-resistant metal-organic framework nanoparticles (UiO-68-NH2) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery.
Date:
September 20, 2021
Creator:
Zou, Jun-Jie; Wei, Gaohui; Xiong, Chuxiao; Yu, Yunhao; Li, Sihui; Hu, Liefeng et al.
System:
The UNT Digital Library