Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells (open access)

Gold Nanoparticles-enabled Efficient Dual Delivery of Anticancer Therapeutics to HeLa Cells

This article describes a facile one-step method to synthesize stable collodial gold nanoparticles (AuNPs) loaded with a combination of two anticancer therapeutics, -bleomycin and doxorubicin
Date: September 20, 2017
Creator: Farooq, Muhammad U.; Novosad, Valentyn; Rozhkova, Elena A.; Wali, Hussain; Ali, Asghar; Fateh, Ahmed A. et al.
System: The UNT Digital Library
Multifeature analyses of vascular cambial cells reveal longevity mechanisms in old Ginkgo biloba trees (open access)

Multifeature analyses of vascular cambial cells reveal longevity mechanisms in old Ginkgo biloba trees

This article investigates age-related changes in Ginkgo biloba trees to learn more about the molecular and metabolic mechanisms underlying their longevity. The results revealed that long-lived trees have evolved compensatory mechanisms to maintain a balance between growth and aging processes.
Date: January 13, 2020
Creator: Wang, Li; Cui, Jiawen; Jin, Biao; Zhao, Jiangou; Xu, Huimin; Lu, Zhaogeng et al.
System: The UNT Digital Library
Natural variation and improved genome annotation of the emerging biofuel crop field pennycress (open access)

Natural variation and improved genome annotation of the emerging biofuel crop field pennycress

Article describing pennycress genome annotation improvements using a combination of long- and short-read transcriptome data obtained from RNA derived from embryos of 22 accessions, in addition to public genome and gene expression information.
Date: April 13, 2022
Creator: García Navarrete, Tatiana; Arias, Cintia Lucía; Mukundi, Eric; Alonso, Ana Paula & Grotewold, Erich
System: The UNT Digital Library
Genome Sequences of Five Streptomyces Bacteriophages Forming Cluster BG (open access)

Genome Sequences of Five Streptomyces Bacteriophages Forming Cluster BG

This article discusses the isolation of five novel phages, which were used to established the cluster BF, using Streptomyces griseus subsp. griseus strain ATcC 10137 as the host.
Date: July 13, 2017
Creator: Donegan-Quick, Richard; Gibbs, Zane A.; Amaku, Patricia O.; Bernal, Joshua T.; Boyd, Dana A. M.; Burr, Angela R. et al.
System: The UNT Digital Library
Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics (open access)

Hypoxia-induced reprogramming of the cardiac phenotype in American alligators (Alligator mississippiensis) revealed by quantitative proteomics

Article describes study which tested if targeted and persistent changes in steady-state protein expression underlie this hypoxic heart phenotype, using isobaric tags for relative and absolute quantitation (iTRAQ) proteomics.
Date: June 13, 2019
Creator: Alderman, Sarah L.; Crossley, Dane A., II; Elsey, Ruth M. & Gillis, Todd E.
System: The UNT Digital Library
Editorial Feature: Meet the PCP Editor—Ana Paula Alonso (open access)

Editorial Feature: Meet the PCP Editor—Ana Paula Alonso

This article is an editorial feature highlighting editor of Plant & Cell Physiology Dr. Ana Paula Alonso. She is currently an Associate Professor in the Department of Biological Sciences and serves as the Director of the BioAnalytical Facility at the University of North Texas.
Date: January 13, 2021
Creator: Alonso, Ana Paula
System: The UNT Digital Library
Mediterranean Spur-Thighed Tortoises (Testudo graeca) Have Optimal Speeds at Which They Can Minimise the Metabolic Cost of Transport, on a Treadmill (open access)

Mediterranean Spur-Thighed Tortoises (Testudo graeca) Have Optimal Speeds at Which They Can Minimise the Metabolic Cost of Transport, on a Treadmill

Article experimentally quantifies the metabolic cost of transport in Mediterranean spur-thighed tortoises walking on a treadmill while also quantifying the kinematics of their movement. Results found that tortoises move more efficiently than predicted and presents the first data demonstrating a curvilinear cost of transport over their speed range. The authors conclude that tortoises have an optimum speed at which they move to minimise their metabolic cost of locomotion.
Date: July 13, 2022
Creator: Ewart, Heather; Tickle, Peter; Nudds, Robert; Sellers, William; Crossley, Dane A., II & Codd, Jonathan
System: The UNT Digital Library
p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas (open access)

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Article identifies exceptional glucose reliance among squamous cell carcinomas (SCC)s dictated by hyperactive GLUT1-mediated glucose influx.
Date: August 13, 2019
Creator: Hsieh, Meng-Hsiung; Choe, Joshua H.; Gadhvi, Jashkaran; Kim, Yoon Jung; Arguez, Marcus A.; Palmer, Madison et al.
System: The UNT Digital Library
The flexibility of proanthocyanidin biosynthesis in plants (open access)

The flexibility of proanthocyanidin biosynthesis in plants

Article presents research that explores proanthocyanidin (PA) biosynthesis routes in plants. The data suggests that different species have evolved different routes for PA biosynthesis.
Date: June 13, 2022
Creator: Lu, Nan; Jun, Ji Hyung; Liu, Chenggang & Dixon, R. A.
System: The UNT Digital Library
Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network (open access)

Sphingolipids mediate polar sorting of PIN2 through phosphoinositide consumption at the trans-Golgi network

Article discovering a mechanism for how sphingolipids mediate phosphoinositide homeostasis at the TGN in plant cells. The data presented identifies a mode of action of sphingolipids in lipid interplay at the TGN during protein sorting.
Date: July 13, 2021
Creator: Ito, Yoko; Esnay, Nicolas; Platre, Matthieu Pierre; Wattelet-Boyer, Valérie; Noack, Lise C.; Fougère, Louise et al.
System: The UNT Digital Library
Phosphorus deprivation affects composition and spatial distribution of membrane lipids in legume nodules (open access)

Phosphorus deprivation affects composition and spatial distribution of membrane lipids in legume nodules

Article assessing membrane lipids in M. truncatula tissues using electrospray ionization–mass spectrometry. The results suggest that specific PC species may be differentially important in diverse nodule zones and cell types, and that membrane lipid remodeling during P stress is not uniform across the nodule.
Date: January 13, 2021
Creator: Dokwal, Dhiraj; Romsdahl, Trevor B.; Kunz, Daniel A.; Alonso, Ana Paula & Dickstein, Rebecca
System: The UNT Digital Library
CancerNet: a unified deep learning network for pan‑cancer diagnostics (open access)

CancerNet: a unified deep learning network for pan‑cancer diagnostics

Article states that despite remarkable advances in cancer research, cancer remains one of the leading causes of death worldwide. The author's proposed framework for cancer diagnostics detects cancers and their tissues of origin using a unified model of cancers encompassing 33 cancers represented in The Cancer Genome Atlas. Their model exploits the learned features of different cancers reflected in the respective dysregulated epigenomes, holding a great promise in early cancer detection.
Date: June 13, 2022
Creator: Gore, Steven & Azad, Rajeev K.
System: The UNT Digital Library
Using Machine Learning to Predict Genes Underlying Differentiation of Multipartite and Unipartite Traits in Bacteria (open access)

Using Machine Learning to Predict Genes Underlying Differentiation of Multipartite and Unipartite Traits in Bacteria

Article describes how, since the discovery of the second chromosome in the Rhodobacter spaeroides 2.4.1 in 1989 and the revelation of gene sequences, multipartite genomes have been reported in over three hundred bacterial species under nine different phyla. In this study, the authors have attempted to leverage machine learning as a means to identify the genetic factors that underlie the differentiation of bacteria with multipartite and unipartite genomes.
Date: November 13, 2023
Creator: Almalki, Fatemah; Sunuwar, Janak & Azad, Rajeev K.
System: The UNT Digital Library