Article on new markers of tumor metastasis. The authors found that expression of DP103 was significantly upregulated in the metastatic basal subtype of breast cancers in 3 independent cohorts. This elevated DP103 expression correlated with metastatic breast cancer gene signatures and was strongly associated with patient survival. This study provides the first evidence that the RNA helicase DEAD-box protein DP103 is an NF-kB target that could form part of a positive feedback loop contributing to DP103- mediated regulation of TAK1 kinase activity on the major NF-kB kinase IKK2, thus implicating DP103 in the maintenance of this oncogenic signaling arm in human cancer.

This article proves an explicit integral representation—involving the pullback of a suitable Siegel Eisenstein series—for the twisted standard L-function associated to a holomorphic vector-valued Siegel cusp form of degree n and arbitrary level.

Article presents a study that reveals the dynamics of transcriptomic responses to age- and dark-induced senescence in M. truncatula and identifies senescence-associated TFs that are attractive targets for future work to control senescence in forage legumes.