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A gene based combination test using GWAS summary data
Article describes how gene-based association tests provide a useful alternative and complement to the usual single marker association tests, especially in genome-wide association studies (GWAS). The authors propose a test named OWC based on summary statistics from GWAS data.
Date:
January 3, 2023
Creator:
Zhang, Jianjun; Liang, Xiaoyu; Gonzales, Samantha; Liu, Jianguo; Gao, Xiaoyi Raymond & Wang, Xuexia
System:
The UNT Digital Library
Gene-based association tests using GWAS summary statistics and incorporating eQTL
Article proposes a powerful and computationally efficient gene-based association test, called Overall. Using extended Simes procedure, Overall aggregates information from three types of traditional gene-based association tests and also incorporates expression quantitative trait locus (eQTL) information into a gene-based association test using GWAS summary statistics. The results show that this newly developed method can identify more significant genes than other methods.
Date:
March 3, 2022
Creator:
Cao, Xuwei; Wang, Xuexia; Zhang, Shuanglin & Sha, Qiuying
System:
The UNT Digital Library