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CAREER: Shape Memory Polymers as Biomaterial
Data management plan for the grant, "CAREER: Shape Memory Polymers as Biomaterial." This CAREER projectaimsto elucidate the underlying mechanism of the plasticization-induced shape memory effect of thiol-enebased polymers. The model application for this material will be a heat shrink tubing that can shrink at bodily conditions (37° C and simulated body fluids) and can be used to seal colonic anastomosis. The specific three aims are to (1) Systematically investigate the effect of crosslink-density and chain extender length on theplasticization-induced shape memory effect of thiol-enebased polymers. Mechanical and thermomechanical measurements inside simulated body fluids will be used to assess shape memory properties and structure-property relationships. (2) Understand the relationship between material thickness, degree of shape-programming, and radial recovery forces of tube-shaped SMPs to determine optimal design parameters for sufficient shape recovery using the heat shrink tube model. (3) Demonstrate the functionality of a biomedical heat shrink tube that utilizes the plasticization-induced shape recovery through an ex vivo colon anastomosis model and quantify mechanical and sealing properties.
Date:
2023-02-01/2028-01-31
Creator:
Ecker, Melanie
System:
The UNT Digital Library
Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease
Data management plan for the grant, "Targeted Systemic Delivery of SDF-1 DNA for the Treatment of Chronic Heart Disease."
Date:
2023-06-01/2023-07-31
Creator:
Won, Youngwook
System:
The UNT Digital Library
Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces
Data management plan for the grant, "Mechanoregulators of Nanoparticle-Cell Interactions at Tissue Interfaces."
Date:
2023-09-01/2028-07-31
Creator:
Meckes, Brian
System:
The UNT Digital Library