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Hedgehog signaling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells
Article states that although KRASG12C inhibitors have shown promising activity in lung adenocarcinomas harboring KRASG12C, acquired resistance to these therapies eventually occurs in most patients. The authors report that the hedgehog signal is induced by KRASG12C inhibitors and mediates KRAS re-expression in cancer cells treated with a KRASG12C inhibitor.
Date:
January 16, 2024
Creator:
Lee, Chaeyoung; Yi, Jawoon; Park, Jihwan; Ahn, Byungyong; Won, Young-Wook; Jeon, JiHeung et al.
System:
The UNT Digital Library
Planar shock compression of spark plasma sintered B4C and B4C-TiB2 ceramic composites
Article describes how blending of ceramic constituent phases enhances sinterability and performance in high strength ceramics. The authors describe how a near fully dense blended boron carbide (B4C)-titanium diboride (TiB2) composite produced through spark plasma sintering (SPS) is probed to understand the mechanical performance under dynamic uniaxial strain, or shock compression.
Date:
January 24, 2024
Creator:
Turnage, Scott A.; Clayton, John D.; Rodriguez, Jonathan; Scharf, Thomas W. & Williams, Cyril L.
System:
The UNT Digital Library