Article describes study which aimed to gain resolution in assessing the energetic demand associated with acid-base regulation by examining ion movement and O2 consumption rates of isolated intestinal tissue from Gulf toadfish acclimated to control or 1900 μatm CO2 (projected for year 2300).

Article describes study suggesting that the inhibation of sphingosine kinase 1 (SPHK1) can attenuate ERK1/2 and AKT signaling and reduce growth of triple-negative breast cancer (TNBC) cells in vitro and in a xenograft SCID mouse model.

Article discusses establishing numerous sets of generalized second order paramertic sufficient optimality conditions for a semiinfinite discrete minmax fractional programming problem, while the results on semiinfinite discrete minmax fractional programming problem achieved based on some partitioning schemes under various types of generalized second order univexity assumptions.

Article investigates basic cardiovascular physiology in the Red Junglefowl, the broiler, and the White Leghorn breeds at 90% of incubation. The authors aimed to identify breed-specific features of arterial blood pressure and heart rate as well as the physiological mechanisms regulating them. They concluded that selection for rapid growth shifts cardiovascular regulatory plasticity to emphasize mechanisms that modulate pressure, and that selection for egg-laying capacity emphasizes mechanisms that modulate heart rate.

Article investigates whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Overall, the results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.

Article describing an investigation into whether γ-tocotrienol can abrogate angiogenesis-mediated tumor growth in hepatocellular carcinoma (HCC) and if so, through what molecular mechanisms.

Article describes study in which researchers employed a natural gradient of rodent species richness and quantified bacterial communities in rodent blood at several hierarchical spatial scales to test the hypothesis that associations between host and microbial species diversity will be positive in communities dominated by organisms with broad niches sampled at large scales.

In this article, the authors evaluate the effect of lupeol on STAT3 signalling cascade and its regulated functional responses in hepatocellular carcinoma (HCC) cells. Constitutive activation of signal transducer and activator of transcription signalling 3 (STAT3) has been linked with survival, proliferation and angiogenesis in a wide variety of malignancies including HCC. Lupeol exhibited its potential anticancer effects in HCC through the downregulation of STAT3-induced pro-survival signalling cascade.

This article is the forward to a special section on long-term ecological research in Chile. It briefly introduces the main topics and ideas of each of the articles and comment on their relevance in the context of research and monitoring of Chilean ecosystems and in the perspective of global change research.

Article describes study which examines backward cooperative emissions from a dense sodium atomic vapor.

In this article, a theoretical understanding is developed of the single-particle reflection properties of a force field, considering the incident charged particles to have a non-drifting, isotropic velocity distribution. Classical trajectory Monte Carlo simulations and analytical modeling are employed. The initiation of an experimental effort to study force fields is described.

Article describes study in which researchers carried out comprehensive evolutionary analyses of the GMP-AMP (cGAMP) synthase (cGAS)-STING pathway.

The article looks at antitumor activity using a matched pair of cell lines MDA-MB-231 cells that are estrogen-independent, estrogen receptor negative and MCF-7 cells, a cell line that is estrogen receptor (ER) positive. Those polyethers that contained a O-phenyl unit were able to significantly inhibit the non-estrogen sensitive cell line but were much less effective against the estrogen sensitive cell line; that is, the human breast cancer cell line MDA-MB-231 showed better test results for polymers derived from diols containing the O-phenyl moiety than the breast cancer cell line MCF-7, a well-characterized estrogen receptor positive control cell line.

This article examines the use of metal-containing polymers as a novel class of antivirals. Polymers containing platinum and to a lesser extent tin, have repeatedly demonstrated antitumor activity in vitro and in vivo against a variety of cell and tumor types. The mechanisms responsible for the antitumor activity include inducing a delay in cell proliferation and sister chromatid exchanges blocking tumor growth.

Describes the development of a Spatial Population Updating System (SPUS) for updating the gridded population database of China based on remote sensing, GIS and spatial database technologies, with a spatial resolution of 1 km by 1 km.

This article based on new archival documents introduces a new episode of mass operations, which took place in June and July of 1927 and was directed against the broad group of “anti-Soviet” forces. It preceded many practices of mass terror of the 1930s with judicial and extra-legal mechanisms. The goal of this article is to explain motivations, justifications, and mechanisms of this repressive campaign and to put this episode in the wider context of Soviet terror. Facing the combination of a perceived danger of war and real internal social hostility expressed in broad defeatism, both threatening the perpetuation of their governmental powers, authorities resorted to repressions. The 1927 episode highlights the factor of a perceived threat of war as a crucial motivating element in Soviet repressive tactics.

With a current population of just over half a million and a 2030 projected population of approximately one million, expansion throughout Denton County shows no sign of slowing down (NCTCOG). Increasingly, freshwater resources are also facing increased pressure from this urban expansion. Effective assessment and management techniques are necessary to protect the diversity of ecosystem services found within fluvial ecosystems and to mitigate current and future conditions of environmental stressor amplified by urban development. The use of various spatial analysis techniques in environmental assessment present more expedient, cost effective, and broader ranging methods of evaluation than traditional field techniques. One such novel evaluation technique is the Water Quality Corridor Management (WQCM) model, developed by the University of North Texas in cooperation with the Upper Trinity Regional Water District (UTRWD). The WQCM model is a geospatial database that utilizes GIS and remote sensing techniques to assess and prioritize stream reaches according to their overall health and sustainability. This project assessed the viability of the WQCM model in reviewing the status of stream systems, and ultimately, established an accurate mechanism for evaluating the stream corridor and surface water quality draining into Lewisville Lake, a popular recreation site and drinking water source for …

This article reports solubility values of vanillin (component 3) in 2-(2-ethoxyethoxy)ethanol (Carbitol®, component 1) + water (component 2) mixtures at five temperatures from 298.15 to 318.15 K correlated with the Jouyban-Acree model combined with van't Hoff or Apelblat equations, and obtains models in second degree regarding the mixtures compositions.

This article characterizes the CETS gene family from tetraploid cotton in order to understand the regulation of cotton architecture and exploit these principles to enhance crop productivity.

This paper identifies the uncertain areas and figures out the problematic land cover types in the MODIS Collection 5 global land cover dataset without ground validation samples.

This article reveals an interaction between the two anti-apoptotic proteins iASPP and NAF-1, which are overexpressed in many types of cancer cells and tumors.

This paper gives a descriptive sketch of the various structures of the Saanich dialect of North Straits Salish has to express attribution and to look at structures similar to those designated relative clauses in other Salishan languages from a cross-linguistic and pan-Salishan point of view.

This paper describes a close look at the distribution in constructions of the closed class of complex predicate forming stems in Klallam traditionally called 'auxiliaries.'

This article establishes uses a Gauss-like relationship to examine how the curvature bundle morphisms relate.