Abstract: This article provides a summary of current literature regarding the nature of spiritual development, types of potentially spiritually transformative experiences (pSTEs), and both short- and long-term aftereffects of pSTEs— biological, psychological, spiritual, and social. The author concludes that in the aftermath of pSTEs, experiencers, their intimates and associates, and their healthcare providers should be prepared to experience integration that can be manageable or be deeply challenging and that can be relatively brief or can last for years.