Alteration in diet and knockdown of detoxification genes impacts the response of C. elegans to oxygen deprivation stress. I hypothesized that feeding worms a vitamin D3-supplementation diet would result in differential oxygen deprivation stress response. We used a combination of wet lab and transcriptomics approach to investigate the effect of a vitamin-D3 supplemented diet on the global gene expression changes and the anoxia response phenotype of C. elegans (Chapter 2). C. elegans genome consists of 143 detoxification genes (cyp and ugt). The presence of a significant number of genes in these detoxification families was a challenge with identifying and selecting specific cyp and ugt genes for detailed analysis. Our goal was to understand the evolution, phylogenetic, and expression of the detoxification enzymes CYPs and UGTs in C. elegans (Chapter 3). We undertook a phylogenetic and bioinformatics approach to analyze the C. elegans, detoxification family. Phylogenetic analysis provided insight into the association of the human and C. elegans xenobiotic/endobiotic detoxification system. Protein coding genes in C. elegans have been predicted to be human orthologs. The results of this work demonstrate the role of C. elegans in the identification and characterization of vitamin D3 induced alterations in gene expression profile and anoxia …

The first Western opera to be performed in Korea was Verdi's La Traviata on January 16, 1948, by the Joseon Opera Company. The first Korean opera, Chunhyangjeon by Jae Myung Hyun, premiered at the Korean National Theater in May 1950, just before the outbreak of the Korean War. Daejeon.go.kr reports that since that year approximately 200 Korean operas have been produced in Korea. Nevertheless, there have been consistent efforts to create and introduce Korean operas to the public. Most of them ended up being "one-off" performances with a single production. Most research on Korean opera has focused on its history, the challenges of producing new operas, or an analysis of selected Korean operas. This study equips singers with the following: pertinent historical background with the libretto, a synopsis, research regarding the composer and librettist, a character analysis, vocal and textual analysis of the selected opera arias, instruction regarding the Korean language, IPA, and a word-by-word translation of the text. I also make recommendations for tenor arias from Korean operas for singers with specific voice types.

This study addressed five key applications of paper spray mass spectrometry (PS-MS): (i) comparative analysis of the microporous substrate with the cellulose-based substrate in drug detection; (ii) detection of more than 190 fentanyl analogs with their fragmentation pattern can be implemented in the future reference for quicker, accurate and sensitive determination; (iii) exploring sweat in a fingerprint to be considered an alternate method to recognize non-invasive markers of metabolites, lipids, narcotics, and explosive residues that can be used in forensic testing applications; (iv) extending and improving better, cost-effective and quick real-time monitoring of the diseased stage using biofluid samples to obtain vastly different lipid information in viral infection such as COVID-19; and (v) mass spectral detection in chemical warfare agent (CWA) stimulant gas exposure with microporous structure absorbency capabilities in air quality monitoring. This novel synthetic material is known as Teslin® (PPG Industries), consisting of a microporous polyolefin single-layered silica matrix, can be used for precise, sensitive, selective, and rapid sample analysis with PS-MS. The Teslin® substrate provided longer activation time for samples and an active signal with a higher concentration of ion formation and mobility compared to cellulose-based papers. Direct analysis of multiple samples showed that, besides being more …

The deposition of boron oxide (B₂O₃) films on silicon substrates is of significant interest in microelectronics for ultrashallow doping applications. However, thickness control and conformality of such films has been an issue in high aspect ratio 3D structures which have long replaced traditional planar transistor architectures. B₂O₃ films are also unstable in atmosphere, requiring a suitable capping barrier for passivation. The growth of continuous, stoichiometric B₂O₃ and boron nitride (BN) films has been demonstrated in this dissertation using Atomic Layer Deposition (ALD) and enhanced ALD methods for doping and capping applications. Low temperature ALD of B₂O₃ was achieved using BCl₃/H₂O precursors at 300 K. In situ x-ray photoelectron spectroscopy (XPS) was used to assess the purity and stoichiometry of deposited films with a high reported growth rate of ~2.5 Å/cycle. Free-radical assisted ALD of B₂O₃ was also demonstrated using non-corrosive trimethyl borate (TMB) precursor, in conjunction with mixed O₂/O-radical effluent, at 300 K. The influence of O₂/O flux on TMB-saturated Si surface was investigated using in situ XPS, residual gas analysis mass spectrometer (RGA-MS) and ab initio molecular dynamics simulations (AIMD). Both low and high flux regimes were studied in order to understand the trade-off between ligand removal and B₂O₃ …

In 1793, the British government embarked on a war against Revolutionary France that few expected would last twenty-five years and engulf all of Europe. Radical French policies provided an opportunity for William Pitt, the British prime minister, to endeavor to cobble a European alliance, including a number of Mediterranean states. These efforts never progressed beyond theory and negotiations because of conflicted policy and tension between the British diplomatic corps and Royal Navy over the strategic goals in the region. With diplomats focused on coalition building and military commanders focused on national objectives, British efforts never congealed into a unified effort to defeat Revolutionary France.

Bohuslav Martinů's "Concerto for Oboe and Small Orchestra" is one of the most frequently played pieces in the oboe repertoire. For this reason, it is often played with the piano reduction instead of the orchestra in oboe recitals. However, the existing piano reductions include many errors and discrepancies from the orchestral score, misrepresent the orchestration, sometimes fail to make the oboe entries clear, and tend to be unplayable for pianists. Moreover, the scores were published after the composer's death without him supervising the final editing. I have prepared a new, playable piano reduction to represent the orchestration more faithfully and help pianists work with their soloists more easily. Based on the work of Martin Katz, a prominent collaborative-pianist, I establish four principles for creating a new piano reduction. After scrutiny of the deficiencies of existing piano reductions, I suggest solutions for making the passages in question practical and bringing out the leading voices clearly so that the soloist can join in as easily as playing with an orchestra. To aid in reflecting the orchestral texture that Martinů created, I include abbreviated instrument names in many passages to help pianists to understand how to create balance. I have changed some passages …

Congenital heart disease is the most common birth defect globally, affecting both children and their families. Twenty –five percent of children experiencing a CHD birth defect are diagnosed with complex CHD (cCHD), signifying critical heart dysfunction requiring one or more open-heart surgeries during the first year of life. With medical advances, cCHD survival rates have almost tripled in the last three decades. This has resulted in an increase in the number of morbidities associated with cCHD, which is drastically impacting the need to support quality of life outcomes for a child with cCHD and their family. The two most prevalent unaddressed risks for quality of life outcomes in the cCHD population are child and caregiver mental health and child's neurodevelopmental disabilities. Congenital heart disease is the most common birth defect globally, affecting both children and their families. Twenty-five percent of children experiencing a CHD birth defect are diagnosed with complex CHD (cCHD), signifying critical heart dysfunction requiring one or more open-heart surgeries during the first year of life. With medical advances, cCHD survival rates have almost tripled in the last three decades. This has resulted in an increase in the number of morbidities associated with cCHD, which is drastically impacting …

Growth mixture modeling (GMM) is a useful tool for examining both between- and within-persons change over time and uncovering unobserved heterogeneity in growth trajectories. Importantly, the correct extraction of latent classes and parameter recovery can be dependent upon the type of covariates used. Time-varying covariates (TVCs) can influence class membership but are scarcely included in GMMs as predictors. Other times, TVCs are incorrectly modeled as time-invariant covariates (TICs). Additionally, problematic results can occur with the use of maximum likelihood (ML) estimation in GMMs, including convergence issues and sub-optimal maxima. In such cases, Bayesian estimation may prove to be a useful solution. The present Monte Carlo simulation study aimed to assess class enumeration accuracy and parameter recovery of GMMs with a TVC, particularly when a TVC has been incorrectly specified as a TIC. Both ML estimation and Bayesian estimation were examined. Results indicated that class enumeration indices perform less favorably in the case of TVC misspecification, particularly absolute class enumeration indices. Additionally, in the case of TVC misspecification, parameter bias was found to be greater than the generally accepted cutoff of 10%, particularly for variance estimates. It is recommended that researchers continue to use a variety of class enumeration indices during …

Using an exploratory case study approach, this study examined the school leadership factors that contribute to building Latinx student social capital as well as the best practices for creating a more equitable AP program. Through this qualitative study, the organizational and leadership factors of the AP program at Stripes High School (pseudonym) were examined, and how these factors contributed toward closing the opportunity gap. This study used semi-structured interviews with district and campus leaders and an AP teachers focus group to determine leadership beliefs and actions that were successful in building an accessible and equitable advanced academics program for Latinx students, as well as an AP student focus group to triangulate the findings. The results of this study showed Latinx students, already lacking social capital, also face many barriers of different forms: systemic, structural and cultural in their educational opportunities for AP courses and exams. The case study campus overcame these barriers and increased equity by allowing Latinx students more access to AP courses and exams through district- and campus-level administrators working to remove barriers and hire and support the most capable and socially aware AP teachers who aim to grow and nurture the students who they serve. Based on …

This work introduces three new coverage criteria based on combinatorial-based event and element sequences that occur in the mobile environment. The novel combinatorial-based criteria are used to reduce, prioritize, and generate test suites for mobile applications. The combinatorial-based criteria include unique coverage of events and elements with different respects to ordering. For instance, consider the coverage of a pair of events, e1 and e2. The least strict criterion, Combinatorial Coverage (CCov), counts the combination of these two events in a test case without respect to the order in which the events occur. That is, the combination (e1, e2) is the same as (e2, e1). The second criterion, Sequence-Based Combinatorial Coverage (SCov), considers the order of occurrence within a test case. Sequences (e1, ..., e2) and (e2,..., e1) are different sequences. The third and strictest criterion is Consecutive-Sequence Combinatorial Coverage (CSCov), which counts adjacent sequences of consecutive pairs. The sequence (e1, e2) is only counted if e1 immediately occurs before e2. The first contribution uses the novel combinatorial-based criteria for the purpose of test suite reduction. Empirical studies reveal that the criteria, when used with event sequences and sequences of size t=2, reduce the test suites by 22.8%-61.3% while the reduced …

This dissertation involves inorganic/organometallic catalysis models, in particular the functionalization of carbon-hydrogen and carbon-carbon bonds. Computational methods have been utilized to better understand the factors affecting the kinetics and thermodynamics of C−H and C−C bond activation/functionalization in this dissertation. Chapter 2 investigates methane C−H activation with a diiminopyridine nitride/nitridyl complex of 3d transition metals and main group elements via three competing pathways: 1,2-addition/[2 + 2] addition, insertion and H-atom abstraction/proton coupled electron transfer. Chapter 3 investigates a transition metal catalyzed C=C bond functionalization involving C−N bond formations to synthesize aziridines from aromatic and aliphatic alkenes. The study focuses on anionic 3d transition metal (M = Mn, Fe, Co and Ni) triphenylamide-amine complexes with nitrene active intermediates for the aziridination reactions. Chapter 4 investigates a disphenoidal Ni(II) azido complex participating in intramolecular C−H functionalization and amination via a putative Ni nitridyl intermediate and a 1,2-addition/[2 + 2] addition pathway. In Chapter 5, methane oxidative addition to the Cp*ML (Cp* = η5-C5Me5; M = Co, Rh, Ir , L = CO, PMe3) motif is compared and contrasted when the classic CO and PMe3 ligands are replaced with the cyclic alkyl(amino) carbene (CAAC) as ancillary ligands.

Neuroscience is a relevant topic for counseling and counselor education, and it is a required area of competency for accredited counseling education programs. Despite this required competency, current counseling literature scarcely addresses neuroscience in counselor education. I have designed the present study to address this scarcity by exploring counselor educators' experiences of incorporating neuroscience into the counselor education curriculum using a consensual qualitative research (CQR) approach. The purpose of this study is to create a foundational understanding of (a) what elements of neuroscience counselor educators are currently including in their courses, and (b) the experience of counselor educators with teaching neuroscience. I interviewed eight counselor educators about their experiences learning and teaching neuroscience. Six domains emerged from the interviews: (1) participants' background and experience, (2) influence of neuroscience on participants' teaching, (3) personal, academic, and professional responses to neuroscience, (4) ethical concerns and recommendations for neuroscience, (5) areas of interest and future research in neuroscience, and (6) counseling literature and publication in neuroscience. The information shared by the participants will contribute to future research of teaching effectiveness and outcomes using neuroscience in counselor education.

The word diaspora is currently understood as the large scale voluntary movement of people, along with capital and goods due to the mechanisms of globalization. Adopting a diaspora, gender and leisure perspective, this dissertation looked at the information and document experiences of a particular fan community of women belonging to the Indian diaspora and the online spaces created and occupied by them (fan fiction blogs which can be viewed as book clubs). The study also looked at memory making and documenting of the same as a part of document experience, resulting in what can be termed as "serendipitous memory archives." The blogs hosting fan fiction and the mediated practices they support were viewed as documents for the study. The online spaces were conceptualized as small worlds and the theoretical framework used for the study consisted of a preliminary model of a small world (based on literature review and my understanding of the world under study), information experience as a concept as well as document experience models. The results show that social ties play a big role in the information and document experience, while memory making and documenting of the same are also seen to happen as part of the document …

This dissertation considers how district-level demographic factors favorable to women congressional candidates facilitate substantive representation of women's interests. I contribute to the existing research by linking the literature on women candidate emergence and electoral success with that on descriptive and substantive representation. Beyond simply asking whether and how women in Congress represent women's interests, I argue that the demographic characteristics of districts in which women are more likely to run and win public office also put women representing those districts in Congress in better position to cultivate feminist homestyles and substantively represent women's interests through legislative behavior. I examine whether women representatives in women-friendly districts are more likely than men representing similar districts, or women in less women-friendly districts, to sponsor legislation in women's issue areas, sponsors women's issue earmarks, and defect from party in women's issue roll-call votes. Overall, I find general support for my theory that district-level factors contribute to observed gender differences in legislative behavior in women's issue areas.

Security and privacy are of paramount importance in the modern information age. Secure multi-party computation and private information retrieval are canonical and representative problems in cryptography that capture the key challenges in understanding the fundamentals of security and privacy. In this dissertation, we use information theoretic tools to tackle these two classical cryptographic primitives. In the first part, we consider the secure multi-party computation problem, where multiple users, each holding an independent message, wish to compute a function on the messages without revealing any additional information. We present an efficient protocol in terms of randomness cost to securely compute a vector linear function. In the second part, we discuss the symmetric private information retrieval problem, where a user wishes to retrieve one message from a number of replicated databases while keeping the desired message index a secret from each individual database. Further, the user learns nothing about the other messages. We present an optimal protocol that achieves the minimum upload cost for symmetric private information retrieval, i.e., the queries sent from the user to the databases have the minimum number of bits.

Harry Sparnaay was a major contributor to the development of unaccompanied works for the bass clarinet and commissioned over 100 pieces for bass clarinet alone. While Sparnaay's book, The Bass Clarinet: A Personal History, includes a list of works written for him, there is minimal information available regarding most of these pieces. This project fills the information gap for this repertoire by providing publication status/score availability, performance challenges, recording history, program notes, and composer information. Each work is classified into three categories based on its publication status and recording history, providing a framework for understanding which works have entered the standard repertoire for the instrument.

Brass musicians are known to experience a performance problem that is sometimes called valsalva maneuver or musical stuttering. This problem is known to cause difficulty starting a first note, tension in the throat, and tightness in the chest. Unfortunately, the research literature lacks sufficient details for evidence-based interventions. Therefore, the purpose of this study is to characterize and define this performance problem as experienced by brass musicians. An online epidemiologic survey was developed and deployed to collect data from brass musicians who have experienced this problem in their own playing. The survey was designed to acquire data in order to characterize and define the phenomenon through a biopsychosocial framework. The survey was also designed to assess whether this problem aligns with Altenmuller's heuristic model of motor control disruptions. A diverse group of brass musicians (n = 252) participated and offered relevant details for characterizing and defining this problem. Analysis of characteristic data suggests this problem is not a form of musical stuttering. Considering these data through Altenmuller's model suggests that this problem is experienced as a spectrum of motor disruptions that can develop into a unique type of musician's dystonia. While additional research is warranted, the results of this study …

During the COVID-19 pandemic in the spring of 2020, universities throughout the United States closed their campuses and transitioned their face-to-face courses to remote learning. The unprecedented transition created a unique learning and teaching environment. This case-based qualitative study investigates the experiences of business professors from a prestigious school of business that taught during the transition. Findings derived from the digital Likert survey instrument completed by all the business faculty and semi-structured interviews of selected business faculty. Some of the topics of the survey and interviews included communicating with students, developing the learning management system course content, delivering asynchronous material, delivering synchronous classes, and providing instructional feedback. Findings included a significant growth in business professor's perceived skillset in almost all topics, an interest in further developing skills, and an interest in adopting the new skills in future face-to-face courses. Through NVIVO analysis of the interviews, four thematical elements were identified: faculty efficacy, faculty training, course delivery, rapport. The study investigated a deep wholistic view of the data presented and provided an extensive in-depth description of the social phenomenon. A practical framework for incorporating the identified themes was developed for business schools needing to establish and maintain online business programs.

When people access online health information, unfortunately, they have access to both clinically accurate and inaccurate information that they may then utilize to make informed personal health decisions. This research fills a gap in the literature of online health communities as they relate to chronic obstructive pulmonary disease (COPD). The conduct of this research required a multi-phased and multi-method approach, best presented in three distinct essays. In Essays 1 and 2, data gathering within two online health communities specific to COPD allowed this study to address three research questions: (1) what are the information needs of COPD patients that result in their participation in online health communities; (2) what are the information sources offered to the participants in these online communities; and (3) is the information obtained via those communities credible. Essay 1 harvested data from a moderated website hosted by a non-profit organization for patients with COPD and Essay 2 harvested data from a non-moderated Facebook group also serving this unique group. Data Miner, a Chrome extension designed to extract data, was used to collect data, key words and themes which brought an understanding of the health information needs of participants and identified what health information sources were preferred. …

Most training performance measurement tools rely heavily on quantitative metrics that do not consider factors impacting knowledge transfer and behavioral change such as social relationships and company culture. This study observed a training performance measurement tool for a major U.S.-based airline. Analysis of the measurement tool consists of: a pilot study providing a baseline for the current gaps in training performance measurement, a survey of flight attendants to understand how company cultural and social factors impact learning and knowledge transfer, and focus groups to provide an in-depth analysis of what the underlying company cultural and social factors are. Both quantitative and qualitative analysis were utilized to identify the impact of cultural factors and social relationships on performance measurement to provide in-depth understanding of the role of tacit knowledge transfer in the training environment. Results show that cultural factors such as empathy, coaching, and on-the-job training, negatively impact the accuracy of flight attendants' ability to measure learning and knowledge transfer. A second finding shows social factors, personality, and agreement, show a strong trend towards negatively affecting the ability to accurately measure learning and knowledge transfer. The proposed knowledge transfer measurement model was further modified to reflect the findings and the results …

Vince Guaraldi (1928-1976) was a jazz pianist who achieved tremendous financial and commercial success in the 1960s with his popular recordings and his work for the Peanuts animated shorts. He cultivated a musical style that drew from several identifiable sources: boogie-woogie, bebop, Brazilian and Afro-Cuban jazz, and rock ‘n' roll. The result was a distinct approach to jazz which, although it may not have been as influential as that of some of his contemporaries, nevertheless constituted a unique and personal voice—what several commentators have referred to as the "Guaraldi sound." This dissertation considers the entire range of Guaraldi's recorded output in order to define and catalog many elements that contributed to Guaraldi's musical style. Using an analytical framework drawn from the work of Leonard Meyer and Benjamin Givan, this study describes both Guaraldi's improvisational style—the licks, patterns, and phrases that he plays while soloing—and common elements of his compositions—the chord progressions, grooves, and other features that are particularly idiomatic. Also discussed are Guaraldi's status within the established jazz canon and the disparity between his widespread popularity and his lukewarm critical reputation. The discussion and analyses provide useful insights for fans of Guaraldi, fans of Peanuts music, jazz musicologists, and any …

One of the major themes in environmental philosophy in the twenty-first century has broadly focused on how we experience and value the natural world. Along those lines, the driving question I take up in this project is if our ordinary experiences are seen as interpretations, what is the significance of this for our moral claims about the environment? Drawing on the hermeneutic philosophies of Hans Georg-Gadamer and Paul Ricoeur, I examine environmental interpretation as it relates particularly to identity, meaningful action, and the mediating function of the imagination. These three interconnected aspects show both our capability for new understandings related to the natural world, as well as problem of conflicting, yet equally valid, views on environmental value. To explore this tension further I consider the relevance of hermeneutic conceptions of truth and translation for environmental ethics. A hermeneutic notion of truth highlights the difficulties in making strong normative claims about the environment, while a hermeneutic view of translation is helpful in thinking about the otherness of nature and what this means for ecological values. In this project I am particularly interested in the conflict of environmental interpretation and the implications that a hermeneutic frame has for the limits of environmental …

The document provides an annotated bibliography of the compositions for clarinet by Dr. Nguyen Phuc Linh, one of Vietnam's foremost contemporary classical musician. Brief biography of Nguyen and his music aesthetic are also included. The dissertation also provides an overview of Vietnamese music and instrumental music.

Continuing the discussion of interpreting J. S. Bach's lute music on the guitar, this dissertation seeks to demonstrate that Schenkerian analysis can assist the modern classical guitarist to better understand Bach's music. In particular, the Schenkerian approach provides an important methodology for studying Bach's music in depth, and then guiding performance practice on the guitar. Although there are many books and articles about transcribing, interpreting and performing Bach's music on the guitar, they do not apply Schenkerian analysis to guitar performance. This research will fill in the lacuna in this field, while promoting music scholarship and enhancing the performance practice of classical guitarists.