This dissertation presents an overview of Church- State relations in Mexico from 1924 to 1938. It examines the actions and motives of prominent national leaders, the papacy, the episcopate, and the Mexican citizenry to determine justification and culpability. This dissertation presents several conclusions. When Calles enforced the anticlerical provisions of the Constitution of 1917, the clergy withdrew from the churches in protest. The episcopate as a body bore a moral responsibility for the Cristero rebellion that resulted, but avoided implication in the movement. Because the Church's supporters were in the minority, that institution in 1929 accepted a settlement requiring clerical obedience to the constitution. Churchmen consoled their parishioners with the thought that the Church would rise again.