Over 9 million new cases of tuberculosis (TB) were reported worldwide in 2013. While the TB rate is much lower in the US, its uneven distribution and associated explanatory variables require interrogation in order to determine effective strategies for intervention and control. However, paucity of case data at fine geographic scales precludes such research. This research, using zip code level data from 837 confirmed TB cases in Tarrant County obtained from Texas Department of State Health Services, explores and attempts to explain the spatial patterns of TB and related risk markers within a framework of place vulnerability. Readily available census data is then used to characterize the spatial variations in TB risk. The resulting model will enable estimations of the geographic differences in TB case variables using this readily available census data instead of time-consuming and expensive individual data collection.