Psychosocial differences between weight loss maintainers and weight loss non-maintainers were compared at least one year after reaching a medically approved weight goal through a medically supervised weight loss program. Research questions addressed differences between groups on the dimensions of somatization, obsessive/compulsive issues, interpersonal sensitivity, depression, anxiety, hostility, ability to resolve past emotional issues, social interpersonal relationships, and tolerance of ambiguity. The all-female sample consisted of maintainers of weight loss (N=30), non-maintainers (N=33), psychotherapy maintainers (N=14), and psychotherapy non-maintainers (N=ll). Research instruments administered were the Symptom Checklist-90-Revised, Fundamental Interpersonal Relations Orientation-Behavior, Personal Orientation Inventory, and Budner Scale for Tolerance/Intolerance of Ambiguity. To determine differences between groups, a t test was performed on data relating to the maintaining and non-maintaining groups. An analysis of variance was performed on data related to the maintaining, non-maintaining, psychotherapy maintaining, and psychotherapy non-maintaining groups. An intercorrelation matrix was completed for all variables. Non-maintainers of weight loss had significantly more difficulty with somatic problems as indicated in the results of both the t test and the analysis of variance (p < .009, p < .02, respectively). Non-maintainers expressed more complaints which focused on cardio-vascular, gastrointestinal, respiratory, and somatic equivalents of anxiety (headaches, pain, discomfort of the …