Ulcerative colitis (UC) is a chronic inflammatory disease characterized by periods of relapses and remissions affecting more than 500,000 people in the United States. To achieve the therapeutic goals of UC, which are to first induce and then maintain disease remission, doctors need to evaluate the severity of UC of a patient. However, it is very difficult to evaluate the severity of UC objectively because of non-uniform nature of symptoms and large variations in their patterns. To address this, in our previous works, we developed two different approaches in which one is using the image textures, and the other is using CNN (convolutional neural network) to measure and classify objectively the severity of UC presented in optical colonoscopy video frames. But, we found that the image texture based approach could not handle larger number of variations in their patterns, and the CNN based approach could not achieve very high accuracy. In this paper, we improve our CNN based approach in two ways to provide better accuracy for the classification. We add more thorough and essential preprocessing, and generate more classes to accommodate large variations in their patterns. The experimental results show that the proposed preprocessing can improve the overall accuracy …

With an ever-growing number of publications in the biomedical domain, it becomes likely that important implicit connections between individual concepts of biomedical knowledge are overlooked. Literature based discovery (LBD) is in practice for many years to identify plausible associations between previously unrelated concepts. In this paper, we present a new, completely automatic and interactive system that creates a graph-based knowledge base to capture multifaceted complex associations among biomedical concepts. For a given pair of input concepts, our system auto-generates a list of ranked subgraphs uncovering possible previously unnoticed associations based on context information. To rank these subgraphs, we implement a novel ranking method using the context information obtained by performing random walks on the graph. In addition, we enhance the system by training a Neural Network Classifier to output the likelihood of the two concepts being likely related, which provides better insights to the end user.