This dissertation research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro to be applied to toxicological research and lipid signaling. Chapter 1 details the effects of chlorine on neuronal network spontaneous electrical activity and pharmacological sensitivity. This study demonstrates that neuronal networks can maintain baseline spontaneous activity, and respond normally to pharmacological manipulations in the present of three times the chlorine present in drinking water. The findings suggest that neuronal networks may be used as biological sensors to monitor the quality of water and the presence of novel toxicants that cannot be detected by conventional sensors. Chapter 2 details the neuromodulatory effects of N-acylethanolamides (NAEs) on the spontaneous electrical activity of neuronal networks. NAEs are a group of lipids that can mimic the effects of marijuana and can be derived from a variety of plant sources including soy lecithin. The most prominent NAEs in soy lecithin, palmitoylethanolamide (PEA) and linoleoylethanolamide (LEA), were tested individually and were found to significantly inhibit neuronal spiking and bursting activity. These effects were potentiated by a mixture of NAEs as found in a HPLC enriched fraction from soy lecithin. Cannabinoid receptor-1 (CB1-R) antagonists and other cannabinoid pathway modulators indicated …

Engelbert Humperdinck (1854-1921), who was considered a Wagnerian due to to his past work in Bayreuth and the Wagnerian traits of his Hänsel und Gretel, seems to have believed that to define himself as a composer, he had to engage somehow with that designation, whether through orthodox Wagner imitation or an assertion of his independence from Wagner's musical legacy. The latter kind of engagement can be seen in Humperdinck's Königskinder (1897), in which he developed a new kind of declamatory notation within the context of melodrama, thus fulfilling Wagnerian ideals as well as progressing beyond them. The effectiveness of Humperdinck's effort is seen in the ensuing critical reception, in which the realities of being heard as a Wagnerian composer are clarified.

Claremont Connections is a collection of fictional short stories about the relationships between the generations of women in one family and their friends.

Recent commercial developments have created a need for alternative materials and methods for imparting oil/grease resistance to paper and/or paperboard used in packaging. The performance of a novel grease resistant functional coating comprised of polyvinyl alcohol (PVA), sodium tetraborate pentahydrate (borate) and acetonedicarboxylic acid (ACDA) and the application of said coating by means of flexographic press is presented herein. Application criteria is developed, testing procedures described, and performance assessment of the developed coating materials are made. SEM images along with contact angle data suggest that coating performance is probably attributable to decreased mean pore size in conjunction with a slightly increased surface contact angle facilitated by crosslinking of PVA molecules by both borate ions and ACDA.

Parents' perceptions of their child's behavior may differ for mothers and fathers. Differences in parental perception may also be apparent in cases of special needs adoptive families with high demands of their child for time, interventions and attention. This paper examines the differences in mother-child and father-child interactions, child behavior as reported by mothers, and fathers and changes in both after participation in an intervention program. Results suggest notable differences between mothers' and fathers' parent-child interaction scores and reports of child behavior. In addition, interaction scores and behavior reports showed some correlations. Finally, there seemed to be notable differences in the trends for the Child Behavior Checklist compared to the two attachment measures (Randolph Attachment Disorder Questionnaire and Beech Brook Attachment Disorder Checklist). Several possible explanations for mother and father differences are discussed.

The purpose was to examine the effect of chronic alcohol abuse on the androgen receptor content (AR) in skeletal muscle, and to determine if this effect was influenced by resistance training. Thirty-four male rats (456 ± 1 g; mean ± SE) were divided into 4 groups: Sham exercise-Ethanol, Sham exercise-Normal diet, Exercise-Ethanol, and Exercise-Normal diet. Both Exercise groups underwent a 6-week "squat" resistance training protocol and both Ethanol groups received an alcohol-rich diet throughout the 6-week period. Western blot analysis showed no effect of alcohol or resistance training on the AR of the extensor digitorum longus. For the rectus femoris, alcohol caused a decline in the AR (p=0.01). This reduction was not attenuated by resistance training. The AR of the soleus was not affected by chronic alcohol abuse alone; however, the resistance training induced increase in the AR was prevented by chronic alcohol abuse (p=0.03).

Photoresist stripping with oxygen plasma ashing destroys the functional groups in organosilicate glass films and induce moisture uptake, causing low-k dielectric degradation. In this study, hexamethyldisilazane (HMDS), triethylchlorosilane and tripropylchlorosilane are used to repair the damage to organosilicate glass by the O2 plasma ashing process. The optimization of the surface functionalization of the organosilicate glass by the silanes and the thermal stability of the functionalized surfaces are investigated. These experimental results show that HMDS is a promising technique to repair the damage to OSG during the photoresist removal processing and that the heat treatment of the functionalized surfaces causes degradation of the silanes deteriorating the hydrophobicity of the films.

The purpose of this study was to evaluate the effects of a training package consisting of response restriction and the reinforcement of self-evaluation on letter reversal errors. Participants were 3 typically developing boys between the age of 5 and 7. The results indicated that the training package was successful in correcting reversals in the absence of a model during training and on application tests. These improvements maintained during subsequent follow-up sessions and generalized across trainers. Fading was not always necessary in correcting reversals, but was effective in correcting reversals that persisted during the overlay training procedures. The advantages to implementing a systematic intervention for reducing letter reversal errors in the classroom, as well as directions for future research, are discussed.

The human opportunistic pathogen, Pseudomonas aeruginosa PAO1, has been shown to kill the nematode Caenorhabditis elegans. C. elegans has been a valuable model for the study of bacterial pathogenesis, and has reinforced the notion that common virulence and host defense mechanisms exist. Recently, the pyrimidine pathway was shown to regulate virulence levels. Therefore, mutations in the pyrimidine pathway of PAO1 showed decrease virulence in the nematode. When starving the nematode, bacterial resistance was also shown to increase. It was hypothesized that starvation induced the DAF pathway, which regulates the transcription of genes involved with the antibacterial defense mechanism. Further research will be conducted to test this theory by performing RNAi experiments for the genes functioning in the antibacterial defense mechanism.

There were two major goals of this study - to examine validity of scores for the Boholst Life Position Scale and to examine potential associations between life positions and affective traits. Two hundred seventy-seven students enrolled in undergraduate psychology classes at a large university volunteered for the study. Concurrent validity of scores for the life position scale was supported based on two compared instruments. Pearson product-moment correlations for the comparisons were -.765 and .617, both statistically significant at the p < .001 level. Factor analysis demonstrated that the scale could accurately be conceptualized as consisting of two factors - an "I" factor and a "You" factor. MANOVA, ANOVA, multiple linear regression, and canonical correlation analysis were used to examine associations between life positions and the affective traits of angry, sad, glad, social anxiety, loneliness, and satisfaction with life. Subjects were catagorized into four groups representing their life position: "I'm OK, you're OK," "I'm OK, you're not OK," "I'm not OK, you're OK," and "I'm not OK, you're not OK." A MANOVA employing life position as the independent variable with four levels and the six affective traits as the dependent variables demonstrated statistical significance (p < .001 level) and h2 was …

The purpose of this study was to determine whether a relationship exists between the Myers-Briggs Type Indicator® (MBTI®) of first-term Air Force medical service corps (MSC) officers and their initial occupational placement matches (OCUPLACE MATCH), and, if so, whether this could it predict job satisfaction. The population consisted of 116 first-term Air Force MSC officers already assigned and working at their initial occupational placement. Statistical Package for the Social Sciences (SPSS®) computer software program was used for the statistical computation. Several techniques were used, including, frequency distribution, the Pearson product-moment correlation coefficient, and regression analyses, among others. Results showed a statistical significant correlation between the MBTI type of the first-term MSC officer matches and their initial occupational placement (OCUPLACE MATCH, r = .440, p < .01). Furthermore, results of a regression analysis showed no statistical significance for predication on job satisfaction (r = 492, F = .887, p < .05). Based on this study, the Air Force Personnel Center can match first-term MSC officers' personality type to an initial occupation placement; however, based on the second part of the hypothesis, prediction of job satisfaction may not be yield on less other aspects of the group are considered such as time …

Self injurious behavior (SIB), such as self-biting and head-banging, has been reported to occur in approximately 10% of captive, individually housed primates (Novak, Kinsely, Jorgensen, and Hazen, 1998). Accounts of the causes of SIB range from environmental to physiological. However, to date, no researchers have investigated the possible influence of social consequences, delivered by handlers and keepers, in the maintenance of SIB. There is only one research report showing that self-injury can be shaped in primates by the manipulation of food as a reinforcing consequence for the animal's behavior. The current study investigated the effects of social contact as potentially reinforcing consequences for the SIB displayed by an olive baboon (Papio hamadryas anubis). Results indicated that the behavior was maintained by attention from humans. As treatment, reinforcement was arranged for an appropriate alternative attention-getting behavior, resulting in increases in the appropriate alternative behavior and decreases in SIB.

Educational researchers, practitioners, and policy makers have long expressed their concern that gender disparity of academic performance and participation in science and mathematics education continues to increase with educational progress of students through the pipeline. Educational and occupational aspirations, high school experience, external support from family members and significant others appear to be influential factors that develop strong self-concept among female students who aspire to study science and mathematics. Using a national sample of aspirants in science, mathematics, and engineering majors in public community colleges, that participated in the 1996 Cooperative Institutional Research Program American Freshman Survey, this study investigated the influences of students' pre-college experiences on their college choice, aspirations, and self-concept by examining three theoretical structural models. In addition, gender differences were tested by using multiple group analysis. The findings from the multiple group analysis revealed that there was no statistically significant gender difference in predicting college choice, aspirations, and self-concept. The results from the descriptive analysis indicated that the female students were already underrepresented in science, mathematics, and engineering majors. Taken together, the findings challenge researchers, practitioners, and policy makers to examine why the persistent fall off, and how can community colleges support and retain these students …

The purpose of this paper is to analyze and identify the major factors that determine the success or failure of mega-sports events. The report begins with a discussion of why localities are willing to invest large sums of public monies in infrastructure and services to host these events. This is followed by a review of the methods used to assess the economic, fiscal, and social impacts of hosting large sporting events. It is observed that comprehensive analyses of the impacts of these events are not undertaken. Finally, the major factors that affect the success of these events are discussed along with suggestions for improving studies evaluating success or failure.

Glutathione syntethase (GS) is an enzyme that belongs to the ATP-grasp superfamily and catalyzes the second step in the biosynthesis of glutathione. GS has been purified and sequenced from a variety of biological sources; still, its exact mechanism is not fully understood. Four highly conserved residues were identified in the binding site of human GS. Additionally, the G-loop residues that close the active site during catalysis were found to be conserved. Since these residues are important for catalysis, their function was studied computationally by site-directed mutagenesis. Starting from the reported crystal structure of human GS, different conformations for the wild type and mutants were obtained using molecular dynamics technique. The key interactions between residues and ligands were detected and found to be essential for enzyme activity.

The thrust of this paper was two-fold, 1) to confirm a 2-factor model of narcissism in women, and 2) to examine the relationship between narcissistic traits in mothers and several variables associated with parenting efficacy. Participants included 193 mother-child dyads. A 2-factor model of narcissism was confirmed in the present sample of mothers, suggesting that narcissistic traits in women may be manifested in distinct Overt and Covert forms. Contrary to expectations, Covert Narcissistic traits in mothers did not significantly correlate with observed parenting behaviors on the PCIA, including Positive Personal Comments (PPC) towards children, Negative Personal Comments (NPC), and Parental Nurturance. However, children's self-reported maternal rejection on the C-PARQ correlated positively with Covert Narcissistic traits in mothers, as did mother's self-reported dysfunctional parenting attitudes on the AAPI-2. Narcissistic traits in mothers correlated most strongly with risk of child physical abuse on the CAPI (r = .70). Results are also presented for the Overt Narcissism factor, which proved to be less stable as a factor. Overall, results emphasize the need for a more comprehensive understanding of narcissism for women, given its potential Implications for children's healthy development and parenting interventions.

The dynamics of growth and formation of surfaces and interfaces is becoming very important for the understanding of the origin and the behavior of a wide range of natural and industrial dynamical processes. The first part of the paper is focused on the interesting field of the random growth of surfaces and interfaces, which finds application in physics, geology, biology, economics, and engineering among others. In this part it is studied the random growth of surfaces from within the perspective of a single column, namely, the fluctuation of the column height around the mean value, which is depicted as being subordinated to a standard fluctuation-dissipation process with friction g. It is argued that the main properties of Kardar-Parisi-Zhang theory are derived by identifying the distribution of return times to y(0) = 0, which is a truncated inverse power law, with the distribution of subordination times. The agreement of the theoretical prediction with the numerical treatment of the model of ballistic deposition is remarkably good, in spite of the finite size effects affecting this model. The second part of the paper deals with the efficiency of the diffusion entropy analysis (DEA) when applied to the studies of stromatolites. In this case …

This study investigated the perceptions of influential relationships between Texas public university presidents, university system chancellors, and state legislators. The study's purpose was to examine Texas public universities engagement in lobbying type behaviors and whether public policy is affected through interaction and communication with legislative leaders. Moreover, of importance for this study was to identifying if Texas public universities actively work to influence the Texas legislature and if lobbying behavior exists whether or not that behavior influences public policy formation within the Texas legislative process. Lastly, this study focused on perceptions dealing with the Texas statute prohibiting state governmental agencies, including public universities and university systems, from influencing legislation through use of state funds. The study was conducted in the winter of 2003 and had 29 president / chancellor respondents and 88 legislator respondents. Three survey instruments were developed by the researcher to determine Texas public university president, system chancellor, and state legislator perceptions and attitudes concerning lobbying type activities, influence, and state statute compliance. Data reported consist of percentages, t-Test of significance, and Cohen's d effect size measure. Results from the study show agreement between the groups in areas of activities utilized to influence the legislative process and actual …

This study examined how technology-mediated distance education is used in special education courses in teacher preparation programs. The data are based on a 30-item survey administered to members of the Teacher Education Division of the Council for Exceptional Children, who identified themselves as serving in an instructional capacity within institutions of higher education. Technology-mediated instruction was characterized in terms course delivery methods and program attributes. An analysis of instructional design processes revealed that most instructors are largely autonomous and do not rely on a team-based approach. Most make use of course-design and management software. Training is linked to course strategy and evaluation, while experience is associated with implementation. Respondents emphasized communication and student feedback. While both users and non-users of distance education technology foresaw the increased use for course delivery in the future, a notable percentage (13%) of current users indicated a desire to discontinue use.

It is said that there is a "productivity paradox" existing in the workplace meaning there are no net benefits from information technology spending. This paper attempts to answer the question as to whether there is a need to account for a change in the growth rate of productivity after the Internet was opened up to commercial use. Using the Chow Test for structural change I concluded that there was indeed a positive change in the growth rate of productivity beginning in the early 1990s that can be associated with increasing Internet usage.

This paper deals with various topics in micro electromechanical systems (MEMS) technology beginning with microactuation, MEMS processing, and MEMS design engineering. The fabrication and testing of three separate MEMS devices are described. The first two devices are a linear stepping motor and a continuous rotary motor, respectively; and were designed for the purpose of investigating the frictional and wear properties of silicon components. The third device is a bi-stable microrelay, in which electrical current conducts through a secondary circuit, via a novel probe-interconnect mechanism. The second half focuses on engineering a carbon nanotube / SU-8 photoepoxy nanocomposite for fabricating MEMS devices. A processing method for this material as well as the initial results of characterization, are discussed.

Non-profits are increasing in size and scope to meet social needs that are unmet by the government. Declining financial support, government regulations, and increasing competition force non-profits to become more professional and efficient. Non-profits increasingly engage in commercial activities, joint ventures with for-profits, and employ business techniques such as business planning and marketing. An extensive body of research examines issues related to non-profit performance that supplies a framework for business planning. Business planning may help non-profits to sustain competitive advantages and long-term financial stability. This paper examines the challenges of writing a business plan for non-profits concluding with a sample business plan that takes into consideration advantages, risks, and limitations of non-profits.

This project consists of an original composition, Voci Lontani, and a critical essay about the composition. In this piece, the idea of musical simultaneity is explored. Therefore, the piece focuses on the idea of contrast: between measured rhythms and indeterminate rhythms, between tonality and atonality, and between musics in separate tempos. In order to explore the significance of musical simultaneity, four important compositional concepts-the simultaneous juxtaposition of different musics, polyrhythmic structure, controlled indeterminacy, and quotation-are discussed. Also, several examples of twentieth-century music that use these concepts are analyzed in the essay.