Ulcerative colitis (UC) is a chronic inflammatory disease characterized by periods of relapses and remissions affecting more than 500,000 people in the United States. To achieve the therapeutic goals of UC, which are to first induce and then maintain disease remission, doctors need to evaluate the severity of UC of a patient. However, it is very difficult to evaluate the severity of UC objectively because of non-uniform nature of symptoms and large variations in their patterns. To address this, in our previous works, we developed two different approaches in which one is using the image textures, and the other is using CNN (convolutional neural network) to measure and classify objectively the severity of UC presented in optical colonoscopy video frames. But, we found that the image texture based approach could not handle larger number of variations in their patterns, and the CNN based approach could not achieve very high accuracy. In this paper, we improve our CNN based approach in two ways to provide better accuracy for the classification. We add more thorough and essential preprocessing, and generate more classes to accommodate large variations in their patterns. The experimental results show that the proposed preprocessing can improve the overall accuracy …

With an ever-growing number of publications in the biomedical domain, it becomes likely that important implicit connections between individual concepts of biomedical knowledge are overlooked. Literature based discovery (LBD) is in practice for many years to identify plausible associations between previously unrelated concepts. In this paper, we present a new, completely automatic and interactive system that creates a graph-based knowledge base to capture multifaceted complex associations among biomedical concepts. For a given pair of input concepts, our system auto-generates a list of ranked subgraphs uncovering possible previously unnoticed associations based on context information. To rank these subgraphs, we implement a novel ranking method using the context information obtained by performing random walks on the graph. In addition, we enhance the system by training a Neural Network Classifier to output the likelihood of the two concepts being likely related, which provides better insights to the end user.

Current unsupervised approaches for keyphrase extraction compute a single importance score for each candidate word by considering the number and quality of its associated words in the graph and they are not flexible enough to incorporate multiple types of information. For instance, nodes in a network may exhibit diverse connectivity patterns which are not captured by the graph-based ranking methods. To address this, we present a new approach to keyphrase extraction that represents the document as a word graph and exploits its structure in order to reveal underlying explanatory factors hidden in the data that may distinguish keyphrases from non-keyphrases. Experimental results show that our model, which uses phrase graph representations in a supervised probabilistic framework, obtains remarkable improvements in performance over previous supervised and unsupervised keyphrase extraction systems.

Implementing a Prolog Runtime System in a language like Java which provides its own automatic memory management and safety features such as built--in index checking and array initialization requires a consistent approach to memory management based on a simple ultimate goal: minimizing total memory management time and extra space involved. The total memory management time for Jinni is made up of garbage collection time both for Java and Jinni itself. Extra space is usually requested at Jinni's garbage collection. This goal motivates us to find a simple and practical garbage collection algorithm and implementation for our Prolog engine. In this thesis we survey various algorithms already proposed and offer our own contribution to the study of garbage collection by improvements and optimizations for some classic algorithms. We implemented these algorithms based on the dynamic array algorithm for an all--dynamic Prolog engine (JINNI 2000). The comparisons of our implementations versus the originally proposed algorithm allow us to draw informative conclusions on their theoretical complexity model and their empirical effectiveness.