This study assesses practices of college students (N=913) toward alternative medicine, relationships of students' health locus of control with practices of alternative medicine, and relationships of students' attitudes toward alternative medicine and health locus of control. A principal components factor analysis established construct validity of the author-designed Attitude Toward Alternative Medicine Scale, extracting three factors: Holistic Attitude/Control, Safety, and Satisfaction. Holistic Attitude/Control predicted use of alternative medicine (Wald =61.9, p < .01). A principal components factor analysis established construct validity of the Multidimensional Health Locus of Control Scale, extracting three factors: Internal Health Locus of Control, External-Chance, and External-Powerful Others. Internal Health Locus of Control significantly correlated with Holistic Attitude/Control (r = .35, p =.01).