In the modern economy, national innovation systems (NIS) contribute to a substantial increase in economic development in numerous parts of the world. NIS has been instrumental in integrating most developing countries' economies into the global capitalist system; however, some developing countries lag the innovation capacities to develop their NIS. The inability of the countries in Sub-Saharan Africa to gauge their NIS is problematic and probably risky for the countries' future development. Without proper evaluation and monitoring, it is hard for governments to create policies to advance their NIS to attain their desired economic development objectives. Development experiences of the countries in Sub-Saharan Africa and their insignificant standings in the global exchange of goods and services warrant a comprehensive way to measure and evaluate their NIS. This study ascertained how predictor variables: government effectiveness index (GEI), percentage of public spending on education (PSE) and labor force (LF) influenced the criterion variables: gross domestic product (GDP), gross national income (GNI) and human development index (HDI). The results categorized the countries that are performing soundly or not, and the knowledge from the assessments can aid in improving national policies for future performance of NIS in Sub-Saharan Africa. Likewise, it can help to create …