In this study the effects of repeated antigen injections on total complement (C') and C'4 of guinea pig serum were investigated to determine if constant antigenic stimulation would show changes in the C' and C'4 titers. Attempts were also made to correlate any changes with variations in antibody titers during the repeated antigen injections.

It was the purpose of the present investigation to determine if sensitivity to other antibiotics can likewise be affected by subjecting S. aureus to heparin contact. It is of special interest in this problem to determine whether heparin in some manner affects the combining process of penicillin with the cells of several strains of S. aureus.

This thesis describes an attempt to increase the life span of mice after injection of a leukemic tumor. Fatty acids were used as a protecting agent against the leukemic tumor.

This paper will attempt to determine whether the increased C'4 previously shown following antigen and adjuvant injection could be correlated to antibody increase following antigen injection.

The purpose of this investigation is to determine the pressure-flow relationships in the isolated canine cerebral vascular bed. These relationships in vessels which supply an organ surrounded by bone are theoretically influenced by limiting factors which are not present in those vessels surrounded by soft tissue. An evaluation of the extent of these limitations is essential to thorough understanding of the dynamics of the cerebral vascular bed.

It was the purpose of the present investigation to demonstrate the selection of a variant of one strain of Staphylococcus aureus by altering certain environmental factors, and to study that variant as to biochemical activities and capsule formation.

The purpose of this investigation was an attempt to clarify the relatives taxonomic position of and to formulate some of the basic cyclic morphological and physiological processes occurring in an aquatic actinomycete possessing streptomycetal characteristics.

The purpose of this investigation is to alleviate this confusion by first testing means of separating the antigenic components of the aerobic actinomycetes--obtaining, if possible, a monospecific antigen. Antisera produced from these monospecific antigens will then be tested for their possible use in the serological grouping of the aerobic actinomycetes.

Many experiments have been performed with the Warburg apparatus, or variations of this manometric technique, since Warburg's experiments (52, 53) where the effects of cyanides upon dark reactions and of urethanes upon light reactions of photosynthesis were demonstrated. The same basic techniques were utilized in this research in attempting to determine the effects of some coordination complexes upon the apparent photosynthetic rate of Chlorella pyrenoidosa. A second goal of the present paper was to investigate the potential of the Warburg apparatus as a tool for screening algicidal compounds.

The purpose of this investigation has been to determine the characteristics of the immune response to 1-fluoro-2,4-dinitrobenzene when this hapten is conjugated with various types of proteins.

The induction of phenylketonuria in mice through the use of excess dietary phenylalanine is an area in which limited research has been done. This study intends to pursue further work in this area, more specifically, to study the effects of excess dietary phenylalanine and the phenylalanine analogue A.P.B.A. (2-amino-3-phenyl butanoic acid) (7) on brain serotonin and brain norepinephrine. In addition, the effects of these two compounds on the incidence of audiogenic seizures will be explored.

For this work, the decision was made to contrast two serological tests, that of the tube agglutination technique and the fluorescent antibody technique for correlation with the coagulase and other characteristics of Staphylococcus strains. This has been a preliminary survey in the hope that as further knowledge is obtained about the staphylococci, grouping of the organisms will become more routine and relatively less complex.

This research is concerned specifically with the growth of two selected algae found surviving in chlorinated water in outdoor swimming pools. Unialgal cultures were used to determine the free chlorine residuals that these algae were able to tolerate.

This thesis compares the specificity of passive transfer of chemical contact hypersensitivity following various methods of sensitization.

It is the purpose of this study to ascertain what environmental factors might cause morphological changes exhibited by certain algae, also to determine if this variation in morphology is vegetative, reproductive, or artifactual in nature, and to show what effects these changes in morpohology might have on classification of the organisms in question.