This thesis is a study of 5-substituted-amino derivatives of 5-phenylhydantoin and anticonvulsant activity.

In view of the unexpected behavior of α-(benzenesulfonyl)-acetophenone toward hydrolysis and because of the possible physiological importance of its derivatives it was deemed of interest to make a further study of the hydrolysis of this compound. It was decided to study both the acid and basic hydrolysis of this compound. The problem consisted of finding a satisfactory means of analyzing the hydrolysis products, and carrying out the hydrolysis under the different conditions.

It has been shown in the case of a compound synthesized in this laboratory that substitution of the thienyl group for one of the phenyl groups in diphenyl hydantoin produces a compound with less toxicity and somewhat greater activity. It was considered of interest to carry out an analogous substitution in the series of 5-phenyl-5-alkoxymethylhydantions.

The project discussed in the paper consists of the substitution of another type of heterocycle, 2-tetrahydropyranyl, in position 5 of the hydantoin nucleus.

The synthesis of several N-(4-nitrophenacyl)-4-alkylpyridinium halides and their reduction products, 1-(4-aminophenyl)-2-[1-(4-alkylpiperidyl)]ethanols, was undertaken because of structural analogies between these and other physiologically active compounds, such as chloroamphenicol (I), 4,4'-diaminodiphenyl sulfone (II), and 2,2-bis(p-aminophenyl)-1,1,1-trichloroethane (III).

This study is about the mercury sensitized photochemical reactions of cyclohexane.

This thesis describes the theoretical results of mercury-sensitized photochemical reactions of isopropyl benzene and methylcyclohexane. The reactions are carried out and the results are analyzed.

This study involves compounds of the barbituric acid series are well known for their use as anesthetics and sedatives.

This thesis describes the creation of substituted diphenylacetic acids and their results.

This thesis is a study of the development of new methods for the quantitative determinations of bismuth and amines.

It is the specific purpose of this investigation to determine the difference, if any, in the amount of practical, everyday chemistry learned by the science majors as opposed to the non-science majors enrolled in general chemistry at the North Texas State College during the school year 1950-1951.

This thesis describes experiments in creating derivatives of sulfonamide. The derivatives were then submitted for testing for anti-tubercular activity.

This paper describes the preparation of pyridine derivatives of 2,3-dichloro-5(8?)-nitro-1,4-naphthoquinone. A method for the nitration of 2,3-dichloro-1,4-naphthoquinone is also described. Certain 4-n-alkyl, 3,4-dialkyl, and 4-cycloalkyl pyridine derivatives are caused to undergo condensation reactions with the nitrated naphthoquinone, giving rise to a series of compounds of the preceding type (X). All of the compounds prepared will be tested for anti-tubercular activity by Parke-Davis and Company.

This thesis describes the process of synthesizing 5-substituted-mercapto derivatives of hydantoin in which the sulfur of the side chain is attached directly to the hydantoin nucleus.

Because of the structural analogies between these compounds and several other physiologically active compounds, such as chloroamphenicol, 4,4'-diaminodiphenyl sulfone, and 2,2-bis-(p-aminophenyl)-1,1,1-trichloroethane, a more complete study of the reduction products and the sequence of catalytic reduction of N-(4-nitrophenacyl)-4-(1-hexyl)pyridinium bromide was made in this investigation.

The acid which is analogous to the next member of the diphenylpolyenes, 1,4-diphenylbutadiene, is muconic acid. This acid has been chosen to be investigated in an effort to isolate all the stereoisomers of a set containing more than two isomers.

A series of analogous reactions employing as a nucleus I-phenylazimidoquinone has been investigated.

This paper is a study of the exchange of bismuth tetra-iodide and bismuth ions in an ion-precipitate system.

The compounds reported here were prepared for the purpose of determining the effects of active groups on the pyridine ring, and to determine the effects of substituted methyl groups on the nucleus. These compounds are to be tested for tuberculostatic activity.

This study discusses the effects of the photochemistry of isopropyl alcohol.

The purpose of this investigation was to study the syntheses of enol lactones and to prepare a series of amide derivatives of these compounds.

Imidazole derivatives of 1,4-naphthoquinones are found to have biological activity which interferes with the utilization of vitamin K or of the purines since they have groups common to these two classes of compounds. This thesis shows the preparation of some 1-substituted-naphthimidazole-4,9-diones for possible biological activity.

This thesis describes the synthesis of a series of 5-alkideniminoxy-5-phenylhydantoins for the purpose of studying their anticonvulsant properties.

This paper concerns the preparation of some bis derivatives of dialkylaminoalkoxypropionitirles from trimethylene, hexamethylene, octomethylene, and decamethylene bromides. These compounds are to be tested for curariform activity and anesthetic values by Parke, Davis and Company.