Language

Theory and Practice in Book 2 of Ugolino's (c. 1380-1457) "Declaratio musicae disciplinae" (open access)

Theory and Practice in Book 2 of Ugolino's (c. 1380-1457) "Declaratio musicae disciplinae"

Ugolino (c. 1380-1457) wrote one of the largest treatises on music theory in the first half of the fifteenth century. This work, the "Declaratio musicae disciplinae," is comprised of five books that cover everything a musician of the era would need to know, from plainchant to harmonic proportions, from musica practica to musica speculativa. However, the treatise has received contradictory interpretations by modern scholars, some viewing it as mainly practical, others as mainly theoretical. I argue that in Book 2, which deals with counterpoint, Ugolino crystallizes the relationship between theory and practice, while offering distinctive contrapuntal practices. Ugolino presents a unique view music's place in the structure of knowledge, one which is highly dependent on Aristotelian philosophy. He posits that music is a science and that it is a branch not of mathematics, as it had traditionally been categorized, but of natural philosophy. This viewpoint shapes the entire treatise and is evident in the book on counterpoint. There, he presents an Italian tradition of teaching counterpoint known as the "regola del grado." Ugolino is the first author to present this tradition entirely in Latin. In addition, he offers an unusual description of musica ficta. In it, he presents a diagram, …
Date: August 2021
Creator: Turner, Joseph (Joseph Alexander)
System: The UNT Digital Library
Mankiyali Phonology: Description and Analysis (open access)

Mankiyali Phonology: Description and Analysis

This thesis provides a detailed description and analysis of the Mankiyali phonology, a hitherto undocumented and endangered language of northern Pakistan. The language is spoken by about 500 people in a remote mountainous area in the Mansehra district of Khyber Pakhtunkhwa Province, Pakistan. The data contained herein is a result of first-hand fieldwork with native Mankiyali speakers between 2019 and 2021. Data collection methods include recordings of naturally occurring discourse (e.g., stories, poems, conversations) and elicitation sessions with native speaker consultants. Topics covered in the thesis include an account of Mankiyali's phonemic inventory, phonotactics, a description of some phonological processes, minimal word constraints, and word stress placement.
Date: August 2021
Creator: Paramore, Jonathan Charles
System: The UNT Digital Library
Where Have All the Cowboys Gone? Creating the Post 9/11 Westerner (open access)

Where Have All the Cowboys Gone? Creating the Post 9/11 Westerner

The intention of this thesis is to analyze the figure of the post 9/11 Westerner as a modern character created from the preexisting archetype of the classic Westerner. 3:10 to Yuma (dir. James Mangold), The Assassination of Jesse James by the Coward Robert Ford (dir. Andrew Dominik), and There Will Be Blood (dir. Paul Thomas Anderson) were released in 2007 and featured post 9/11 Westerners dealing with issues of fatherhood, demonstrating the prevalence of this figure within the modern western genre. Fatherhood becomes the prism through which these characters are depicted, which becomes the main source of their anxiety. The events of 9/11 contributed to a fracture of the western myth established by the classic postwar western that results in the post 9/11 Westerner attempting to reclaim a similar mythic status. The post 9/11 Westerner becomes an inversion of the classic Westerner seen through his insecure masculinity and ultimate failure to live up to his own imagined ideals.
Date: August 2021
Creator: Possoit, Dylan
System: The UNT Digital Library

Electrical Equivalent Modeling of the Reverse Electrowetting-on-Dielectric (REWOD) Based Transducer along with Highly Efficient Energy Harvesting Circuit Design towards Self-Powered Motion Sensor

Among various energy harvesting technologies reverse electrowetting-on-dielectric energy harvesting (REWOD) has been proved to harvest energy from low frequency motion such as many human motion activities (e.g. walking, running, jogging etc.). Voltage rectification and DC-DC boosting of low magnitude AC voltage from REWOD can be used to reliably self-power the wearable sensors. In this work, a commercial component-based rectifier and DC-DC converter is designed and experimentally verified, for further miniaturization standard 180 nm CMOS process is used to design the rectifier and the DC-DC boost converter.This work also includes the MATLAB based model for REWOD energy harvester for various REWOD models. In REWOD energy harvesting, a mechanical input during the motion causes the electrolyte placed in between two dissimilar electrodes to squeeze back and forth thereby periodically changing the effective interfacial area, hence generating alternating current. The alternating current is given to the rectifier design. There is no realistic model that has been developed yet for this technique. Thereby, a MATLAB based REWOD model is developed for the realistic simulation of the REWOD phenomenon. In the work, a comparison of different REWOD models such as planar surface, rough surface and porous models are performed demonstrating the variations in capacitance, current …
Date: August 2021
Creator: Gunti, Avinash
System: The UNT Digital Library
Resilience in the Face of Stress: Gender Differences in the Relationship between Resilience and Stress among Lesbian and Gay Older Adults in the American South (open access)

Resilience in the Face of Stress: Gender Differences in the Relationship between Resilience and Stress among Lesbian and Gay Older Adults in the American South

The minority stress model provides context to understand the mechanisms by which prejudicial experiences contribute to the disproportionate prevalence of adverse physical and mental health outcomes among LGBT people. The transactional model of stress and coping explains the appraisal processes through which people identify stigma-related stimuli as threatening and how they assess available coping resources to counteract these threats. The Connor-Davidson Resilience Scale (CD-RISC) and the Perceived Stress Scale (PSS) were used in this study to measure resilience and stress in a sample of 99 lesbian and gay older adults. Women reported statistically significantly higher levels of resilience and lower levels of perceived stress compared to older gay men. An analysis of covariance (ANCOVA) revealed statistically significant main effects for gender (Cohen's d = .51; ηp2 = .056; F(1,98) = 5.488, p = .021) while controlling for perceived stress (Cohen's d = 1.62; ηp2 = .375; F(1,98) = 55.840, p < .001). An interaction effect between gender and perceived stress was also statistically significant (Cohen's d = .72; ηp2 = .115; F(1,98) = 12.40, p < .001) indicating that the negative relationship between stress and resilience is stronger for older gay men. Clinical implications and relevance to future research are …
Date: August 2021
Creator: Poché, Barton J
System: The UNT Digital Library
Ecological Responses to Severe Flooding in Coastal Ecosystems: Determining the Vegetation Response to Hurricane Harvey within a Texas Coast Salt Marsh (open access)

Ecological Responses to Severe Flooding in Coastal Ecosystems: Determining the Vegetation Response to Hurricane Harvey within a Texas Coast Salt Marsh

Vegetative health was measured both before and after Hurricane Harvey using remotely sensed vegetation indices on the coastal marshland surrounding Galveston Island's West Bay. Data were recorded on a monthly basis following the hurricane from September of 2005 until September of 2019 in order to document the vegetation response to this significant disturbance event. Both initial impact and recovery were found to be dependent on a variety of factors, including elevation zone, spatial proximity to the bay, the season during which recovery took place, as well as the amount of time since the hurricane. Slope was also tested as a potential variable using a LiDAR-derived slope raster, and while unable to significantly explain variations in vegetative health immediately following the hurricane, it was able to explain some degree of variability among spatially close data points. Among environmental factors, elevation zone appeared to be the most key in determining the degree of vegetation impact, suggesting that the different plant assemblages that make up different portions of the marsh react differently to the severe flooding that took place during Harvey.
Date: August 2021
Creator: Hudman, Kenneth Russell
System: The UNT Digital Library
Classical Simulations of the Drift of Magnetobound States of Positronium (open access)

Classical Simulations of the Drift of Magnetobound States of Positronium

The production and control of antihydrogen at very low temperatures provided a key tool to test the validity for the antimaterial of the fundamental principles of the interactions of nature such as the weak principle of equivalence (WEP), and CPT symmetry (Charge, Parity, and Time reversal). The work presented in this dissertation studies the collisions of electrons and positrons in strong magnetic fields that generate magnetobound positronium (positron-electron system temporarily bound due to the presence of a magnetic field) and its possible role in the generation of antihydrogen.
Date: August 2021
Creator: Aguirre Farro, Franz
System: The UNT Digital Library
Formation Control and Path Planning Strategies for Unmanned Aerial Vehicle Swarms (open access)

Formation Control and Path Planning Strategies for Unmanned Aerial Vehicle Swarms

This dissertation focuses on the path planning of unmanned aerial vehicle (UAV) swarms under distributed and hybrid control scenarios. It presents two such models and analyzes them both from theory and practice. In the first method, a distributed formation control strategy for UAV swarm based on consensus law is presented. This model makes use of the fundamental concepts of leader-follower structure, social potential functions, and algebraic graph theory to jointly address flocking and de-confliction in the formation control problem. The impact of network topology on formation control is analyzed. It is shown that the degree distribution of the network representing the multi-agent system defines the rate at which formation is attained. Conditions for convergence and stability are derived. In the second method, a hybrid framework for path planning and coverage area by UAV swarms is presented. This strategy significantly improves the current labor-intensive and resource-constraint operations in aquaculture farms. To monitor the farms periodically, an optimized back-and-forth flight path based on the Shamos algorithm is utilized. A trajectory tracking strategy for UAV swarms under uncertain wind conditions is presented.
Date: August 2021
Creator: Mukherjee, Srijita
System: The UNT Digital Library
Where Bach Meets Jazz: A Critical Edition of Anthony Plog's (b. 1947) Concerto for Flute and Wind Ensemble with Commentary, Revisions, and Additions by the Composer (open access)

Where Bach Meets Jazz: A Critical Edition of Anthony Plog's (b. 1947) Concerto for Flute and Wind Ensemble with Commentary, Revisions, and Additions by the Composer

Anthony Plog's Concerto for Flute and Wind Ensemble is a substantial but relatively unknown work from the composer's early compositional period. It deserves wider exposure and recognition in the repertoire for solo flute and wind ensemble, given its accessibility for both the soloist and the ensemble.
Date: August 2021
Creator: Flum, Kathryn
System: The UNT Digital Library

Low-Energy Electron Irradiation of 2D Graphene and Stability Investigations of 2D MoS2

In this work, we demonstrate the mechanism for etching exfoliated graphene on SiO2 and other technological important substrates (Si, SiC and ITO), using low-energy electron sources. Our mechanism is based on helium ion sputtering and vacancy formation. Helium ions instead of incident electrons cause the defects that oxygen reacts with and etches graphene. We found that etching does not occur on low-resistivity Si and ITO. Etching occurs on higher resistivity Si and SiC, although much less than on SiO2. In addition, we studied the degradation mechanism of MoS2 under ambient conditions using as-grown and preheated mono- and thicker-layered MoS2 films. Thicker-layered MoS2 do not exhibit the growth of dendrites that is characteristic of monolayer degradation. Dendrites are observed to stop at the monolayer-bilayer boundary. Raman and photoluminescence spectra of the aged bilayer and thicker-layered films are comparable to those of as-grown films. We found that greater stability of bilayers and thicker layers supports a previously reported mechanism for monolayer degradation involving Förster resonance energy transfer. As a result, straightforward and scalable 2D materials integration, or air stable heterostructure device fabrication may be easily achieved. Our proposed mechanisms for etching graphene and ambient degradation of MoS2 could catalyze research on realizing …
Date: August 2021
Creator: Femi Oyetoro, John Dideoluwa
System: The UNT Digital Library

The Changing Role of On-Air Women Journalists: Journalists on Local Television News and Digital Influencers on Instagram

This thesis looks at how women journalists are now also digital influencers on Instagram. It analyzes the gendered expectations of women journalists that are also included on their professional Instagram accounts.
Date: August 2021
Creator: Lara, Sarah
System: The UNT Digital Library

Self-Healing Ceramics for High Temperature Application

Ceramics have a wide variety of applications due to their unique properties; however, the low fracture toughness leads the formation and propagation of unpredictable cracks, and reduces their reliability. To solve this problem, self-healing adaptive oxides were developed. The aim of the work is to gain new insights into self-healing mechanisms of ceramics and their application. Binary oxide systems were investigated that are at least partially healed through the extrinsic or intrinsic addition of silver or silver oxide to form ternary oxides (e.g., Nb2O5 + Ag → AgNbO3). Sintered pellets and coatings were tested. For self-healing TBCs, model systems that were studied include YSZ-Al2O3-SiC, YSZ-Al2O3-TiC, YSZ-Al2O3-Nb2O5, and YSZ-Al2O3-Ta2O5. Laser cladded samples and sintered pellets were produced to test. The healing process occurs due to the formation of oxidation products and glassy phases depending on the self-healing mechanism. X-ray diffraction was used to explore phase evolution, chemical compositions, and structural properties of these samples. SEM equipped with EDS was used to investigate the chemical and morphological properties for the cross-sectional area. Pin-on-disc test was applied to test tribology performance for Nb2O5-Ag2O system, and infiltration test was applied to test CMAS-resistance for TBCs at elevated temperature. The improvements in the performance of …
Date: August 2021
Creator: Gu, Jingjing
System: The UNT Digital Library
An Investigation of College Graduates' and Employers' Perceptions of Graduates' Social Skills Performance in Vietnam (open access)

An Investigation of College Graduates' and Employers' Perceptions of Graduates' Social Skills Performance in Vietnam

Vietnam currently faces a social skills deficit among college graduates. This lack of sufficient social skills significantly affects Vietnam's economy where it is one of the main factors that drives higher unemployment in Vietnam. Research has shown that although social skills have been increasingly perceived by employers as one of the most important factors for graduate employability and career success, the absence of social skills training in colleges and universities have caused graduates to be ill-prepared for the workplace, which lead to dissatisfactions among employers and complications when seeking for potential hires in Vietnam. Therefore, this study aims to examine and compare perceptions of Vietnamese college graduates and employers on graduates' social skill performance. Given the objectives of this study, an online survey was distributed to potential participants across Ho Chi Minh City, Vietnam. Analysis of the responses not only demonstrated a disconnect of perceptions between employers and newly hired graduates (NHGs) on how these two groups rated graduates' performance of interpersonal skills but also revealed a mismatch in the perceptions of the comparing groups on how they perceive the importance of social skills in graduate employment. As a result, it is recommended that Vietnam need to promote and support …
Date: August 2021
Creator: Bui, Tu Quyen Thi
System: The UNT Digital Library

A Study of Health-Related Screening Behaviors among Individuals in Texas with Adverse Childhood Experiences

Data from this dissertation was obtained from the Texas Behavioral Risk Factor Surveillance System (BRFSS). The Texas BRFSS questionnaire used a cross-sectional retrospective research design while asking questions about individuals' exposure to adverse childhood experiences (ACEs) and included 11 questions. The sample included 9096 individuals over the age of 18 who had exposure to at least one ACE. An ACE score was calculated for all participants and were divided into two groups (less than 4 ACEs and more than 4 ACEs) to compare whether differences in ACE score would impact participating in routine health screening or not. Additionally, whether different kinds of ACEs would impact health screening was also examined. Logistic regression was used to assess whether different kinds of ACEs impact participation in routine health screening. This study found that individuals with a history of childhood adversities including experiencing childhood emotional abuse, living in a dysfunctional household impeded them from participating in routine health screenings. It is recommended that both primary care physicians and mental health providers to use motivational interviewing while interacting with patients with ACE histories. It is also suggested that using trauma-informed care (TIC) in primary care can help patients talk about their abuse histories and …
Date: August 2021
Creator: Baniya, Ganesh
System: The UNT Digital Library
Korean Diction for Non-Korean-Speaking Singers: A Study for Singing Korean Art Songs (open access)

Korean Diction for Non-Korean-Speaking Singers: A Study for Singing Korean Art Songs

Korean art songs are valuable cultural assets that exhibit their own cultural spirit and ethnicity, however, they are not introduced to Western singers because of the language barrier. As there are European-language diction books for singers used in pedagogy, this dissertation introduces Korean diction for non-Korean-speaking singers by using the International Phonetic Alphabet (IPA) to pronounce Korean ‘Hangeul'. Moreover, this document aims to help singers enter into a new world of Korean art songs by introducing ten Korean art songs selected from various compositional periods, along with transcriptions using the IPA, transliterations, translations, and the musical scores.
Date: August 2021
Creator: Nho, Ji Yoon
System: The UNT Digital Library
Activating Artistry: Community Engagement Resources and Teaching Artist Strategies for the Bassoonist (open access)

Activating Artistry: Community Engagement Resources and Teaching Artist Strategies for the Bassoonist

This document examines current practices and opportunities in the music performance field related to artistic citizenship, community engagement, and the field of teaching artistry. The relationship of musicians to their audiences and communities has shifted significantly in the twenty-first century, and there is an increasing need to redefine the essential skills of the professional musician. Derived from the field of teaching artistry, the concept of "activating artistry" suggests that our greatest strength and power as artists lies in drawing out individual artistic expression in other people, and it is with this power that artists as a workforce can create meaningful change in society. This intention could be manifested in many different contexts during the course of a given music career, however, developing the tool kit necessary for engaging in such work is not widely emphasized in the training of musicians. What tools can be provided for students and professionals to help them navigate both traditional and evolving career paths in music? How are bassoonists doing as a field in addressing the imperative of community engagement and artistic citizenship? How might we explore more collaborative ways to engage with our diverse communities – ways that value their perspectives? These questions guide …
Date: May 2021
Creator: Spring, Staci
System: The UNT Digital Library
An Introduction to the Piano Works of William Mason (1829-1908) and a Performance Guide to Selected Repertoire for Intermediate Students (open access)

An Introduction to the Piano Works of William Mason (1829-1908) and a Performance Guide to Selected Repertoire for Intermediate Students

William Mason (1829–1908) was a well-known American composer, pianist, and pedagogue. Researchers have mainly focused on Mason's career as a pedagogue in the United States and his pedagogical treatises, which are widely considered and used as the conceptual core of teaching materials on the nineteenth century. However, there has been only an annotated catalogue of Mason's music works, and no performance guide to his piano compositions. This dissertation is designed to be the first performance guide to his solo piano repertoire and act as an introduction to his music through an examination of selected works suitable for the intermediate student. This study provides instruction for students on how to practice these works through the analysis of the elements of practice – pedaling, phrasing, technique practice, touch, and musical expression – which were all considered as essential by Mason himself for a good performance. The five piano works selected are: Three Preludes, Op. 8, No. 1; Ballade et Barcarole, Op. 15; Valse Caprice, Op.17; Spring-Dawn, Mazurka–Caprice, Op. 20; and Spring Flower–Impromptu, Op. 21.
Date: May 2021
Creator: Chen, Ying-Chieh
System: The UNT Digital Library
Community First: An Ethnographic Approach to Understanding Local Perceptions of Sustainability in the Age of Neoliberalism (open access)

Community First: An Ethnographic Approach to Understanding Local Perceptions of Sustainability in the Age of Neoliberalism

This work describes ethnographic research completed in order to understand how local community members in Denton, Texas define, conceptualize, and speak about sustainability. The goal of this research is to encourage a more representative approach to sustainability initiatives within the City of Denton by uniting community ideas with local governance. Data for this study was collected through semi-structured interviews with residents, participant observation at community meetings, and quantitative survey analysis. Through the use of a Foucauldian framework for analysis, in conjunction with David Harvey's "entrepreneurial city," and work done in the field of environmental justice, this study highlights a potential link between neoliberal approaches to city governance and community perceptions of sustainability. This research concludes by calling for more representation of all community members within local sustainability initiatives, and provides several suggestions for how this can be achieved.
Date: May 2021
Creator: LeMay, Brittany Michelle
System: The UNT Digital Library
Metal, Pedagogy, Women, Kuwait: An Autoethnographic Feminist Approach to Questioning Systems of Education (open access)

Metal, Pedagogy, Women, Kuwait: An Autoethnographic Feminist Approach to Questioning Systems of Education

This research seeks to explore how the metal arts are taught to women in Kuwait in an undergraduate setting, making the call for the use of feminist pedagogy when teaching the metal arts to women in Kuwait. This research is achieved using the qualitative methodology of analytic autoethnography. The theoretical framework is a feminist lens bridging the social construction of gender with the gendering of objects and feminist standpoint theory. The data comes from the experiences of creating three of my own pieces of artwork as well as the pieces themselves in tandem with historical, political, and cultural contexts. The analysis from this research is then bridged with feminist pedagogy in order to begin to develop an inclusive metal arts curriculum for women in Kuwait.
Date: May 2021
Creator: Alayar, Moneerah
System: The UNT Digital Library
Social Media Usage among First Responders to Hurricane Harvey (open access)

Social Media Usage among First Responders to Hurricane Harvey

Social media plays an important role during multiple phases of a disaster. While it is widely known that citizens turn to social media during disasters to gain information and send help requests, there is a significant gap in our knowledge of how, or if, first responders use social media to conduct disaster response operations. To help address this gap this study employed qualitative, semi-structured interviews with a sample of first responders (N = 20) who were deployed to Hurricane Harvey in 2017. The interviews sought to gain a better understanding of how social media was used to conduct response operations and identify both limitations and advantages of social media as perceived by first responders. Through a systematic coding process the analysis identified four themes related to social media usage among first responders to disasters: (1) more than just Twitter; (2) rumor has it; (3) one size does not fit all; and (4) timing is everything. The findings of this research highlight the importance of social media for both organizations and individuals involved in responding to disasters.
Date: May 2021
Creator: Spinuzzi, Lacey Cook
System: The UNT Digital Library
Teachers' Technology Adoption in Cross-Cultural Classroom: A Transformative Perspective (open access)

Teachers' Technology Adoption in Cross-Cultural Classroom: A Transformative Perspective

In the current globalizing society, teachers are provided opportunities to move across their national borders to seek learning, professional development, and working opportunities. Technology-related professional development is particularly valued for teachers' sojourn to the technology intensive cultures. This qualitative cross-case study explored the K-12 Chinese language teachers' changes of teachers' application and perspective toward educational technology in cross-cultural teaching context through the lens of transformative learning theory. The qualitative data is collected from the interviews with 20 teacher participants in the four stages of cross-cultural sojourning: pre-departure, currently sojourning, post-sojourn, and immigrated. A qualitative cross-case analysis is conducted to compare the characteristics of teachers in different cases, and developed the complete process of the cross-cultural technology adoption and perspective. Factors contributed to the changes are also identified. Five issues related to the process are discussed. Implications and future directions were also included.
Date: May 2021
Creator: Meng, Nanxi
System: The UNT Digital Library
Restore, Reform, React, Revolt: Leopold II and the Risorgimento in the Grand Duchy of Tuscany, 1814-1859 (open access)

Restore, Reform, React, Revolt: Leopold II and the Risorgimento in the Grand Duchy of Tuscany, 1814-1859

The Risorgimento or "resurrection" of Italy united a collection of independent Italian kingdoms, duchies, and principalities under the auspices of the Piedmontese House of Savoy. No longer was Italy a mere expression géographique, as Austrian Chancellor Klemens von Metternich snidely remarked in 1847, but a united nation state. Studies of the Risorgimento successfully highlight the role of famous Piedmontese and Italian nationalists in demonstrating the success of the movement. However, the smaller states of the peninsula have largely disappeared from these histories. Among these overlooked states is the Grand Duchy of Tuscany and Tuscany's last grand duke, Leopold II of Habsburg-Lorraine. Both are consistently omitted from broader surveys of the peninsula. In rare situations when Leopold II enters the historical narrative he is dismissed as a reactionary, although he maintained a reputation as an enlightened and relatively liberal ruler for the majority of his rule. Especially in anglophone literature, little to no discussion of his thirty-five-year reign is available. This omission creates an unfortunate lacuna in the historiography of the Risorgimento. It is in studies of these smaller Italian states that the intricacies of statecraft, nationalism, and localism are most visible. To understand the extent of the Risorgimento's success, it …
Date: May 2021
Creator: Parkey, Rachel E.
System: The UNT Digital Library
Queerness, Futurity, and Desire in American Literature: Improvising Identity in the Shadow of Empire (open access)

Queerness, Futurity, and Desire in American Literature: Improvising Identity in the Shadow of Empire

This dissertation deploys queer theory and temporality to investigate the ways in which American authors were writing about identity at the turn of the twentieth century. I provide a more expansive use of queer theory, and argue that queerness moves beyond sexual and gender identity to have intersectional implications. This is articulated in the phrase "queer textual libido" which connects queer theory with affect and temporal theories. Queerness reveals itself on both narrative and rhetorical levels, and can be used productively to show the complex navigation between individual and national identity formation.
Date: May 2021
Creator: Vastine, Stephanie Lauren
System: The UNT Digital Library
The Development of Potential Therapeutic Anti-Myosin S2 Peptides that Modulate Contraction and Append to the Heart Homing Adduct Tannic Acid without Noticeable Effect on Their Functions (open access)

The Development of Potential Therapeutic Anti-Myosin S2 Peptides that Modulate Contraction and Append to the Heart Homing Adduct Tannic Acid without Noticeable Effect on Their Functions

This dissertation aimed to explore the S2 region with an attempt to modulate its elasticity in order to tune the contraction output. Two peptides, the stabilizer and destabilizer, showed high potential in modifying the S2 region at the cellular level, thus they were prepared for animal model testing. In this research, (i) S2 elasticity was studied, and the stabilizer and destabilizer peptides were built to tune contraction output through modulating S2 flexibility; (ii) the peptides were attached to heart homing adducts and the bond between them was confirmed; and (iii) it was shown that minor changes were imposed on the modulating peptides' functionality upon attaching to the heart homing adducts. S2 flexibility was confirmed through comparing it to other parts of myosin using simulated force spectroscopy. Modulatory peptides were built and computationally tested for their efficacy through interaction energy measurement, simulated force spectroscopy and molecular dynamics; these were attached to heart homing adducts for heart delivery. Interaction energy tests determined that tannic acid (TA) served well for this purpose. The stoichiometry of the bond between the TA and the modulating peptides was confirmed using mass spectroscopy. The functionality of the modulating peptides was shown to be unaltered through expansion microscopy …
Date: May 2021
Creator: Qadan, Motamed
System: The UNT Digital Library